Fewer than half of clinical trial sponsors reported their results to a U.S. government registry within a year of the trial’s completion, flouting U.S. law and risking fines, British researchers reported. In a study they found that in spite of legal efforts to curb well-documented lapses in reporting of negative trial results, many sponsors are still not reporting their findings, potentially keeping patients and doctors in the dark about benefits and side effects of treatments.
News
Jan 17, 2020
According to new findings in the American Heart Association's journal Circulation: Cardiovascular Quality and Outcomes - too few people covered by Medicare participated in outpatient cardiac rehabilitation after a heart attack or acute heart event or surgery, particularly women, the elderly and non-white patients. Outpatient cardiac rehabilitation has been shown to improve health outcomes among patients who have heart failure, have suffered heart attacks or have undergone a cardiac procedure such as coronary artery bypass surgery.
Jan 17, 2020
The novel 2HELPS2B score is useful for predicting inpatient seizure risk and determining appropriate continuous EEG monitoring durations, researchers report. Only 1 hour of screening EEG is needed to accurately calculate the 2HELPS2B score. They hope this result make 2HELPS2B more clinically useful. Dr. Struck and colleagues used machine-learning methods to develop the 2HELPS2B scoring system with the goal of improving seizure prediction. It incorporates 5 EEG features and a single clinical factor (prior seizure).
Journal Abstracts
Jan 16, 2020
The aim of this prospective study was to evaluate natural colicin and microcin production by large intestinal mucosal bacteria in each stage of colorectal neoplasia and in those with a history of colorectal neoplasia. Strains isolated from large intestinal mucosa in patients with colorectal neoplasia produce colicins and microcins more frequently compared to controls. Bacteriocin production does not differ between patients with current and previous colorectal neoplasia. Fundamental differences in bacteriocin production have been confirmed between males and females.
Jan 16, 2020
Cristina SilvaMeira-Strejevitch et al obtained plasma samples from 51 patients with ocular toxoplasmosis (OT Group), 26 people with asymptomatic toxoplasmosis (AT Group), and 25 healthy people seronegative for toxoplasmosis (NC Group) in this study, to assess gene expression of microRNA (miR)-155-5p, miR-146a-5p, miR-21-5p, miR-29c-3p and miR-125b-5p in these samples. According to the findings, compared with AT people, OT patients had up-expressed miR-155-5p and miR-29c-3p. In OT patients, down-expressed miR-21-5p and miR-125b-5p were detected. Differences were statistically significant. Experts noted a similar miR-146a-5p expression in OT patients and AT people, without significant difference. These findings were verified in comparative analysis for microRNA (miRNA) levels between AT and OT groups. The circulating miRNA levels in ocular toxoplasmosis were assessed for the first time ever in this study.
Jan 16, 2020
Bei Shi et al examined if women with polycystic ovary syndrome (PCOS) exhibit altered fructose levels. At Shengjing Hospital of China Medical University, they recruited a total of 157 Chinese Han women (67 controls and 90 PCOS patients). Measurement of fructose levels was done in serum samples obtained from 80 patients with PCOS (32 lean, 48 overweight/obese) and 59 control women (27 lean, 32 overweight/obese) and in follicular fluid samples obtained from mature follicles (17–22 mm) and matched immature follicles (8–13 mm) from 10 patients with PCOS and 8 control women. As per outcomes, the Chinese Han women with overweight/obesity and hyperinsulinemia exhibit a correlation of elevated serum fructose levels with PCOS. Follicular fluids from PCOS patients exhibit higher fructose levels than from control women.
Recent Articles
Jan 18, 2020
This multi-faceted book provides readers with comprehensive guidance to spine pain care. This six-part reference begins with a review on the epidemiology and economic impacts that present clinical and financial challenges for spine pain care.
Jan 18, 2020
This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Advancing the Science of Cancer in Latinos proves to be an indispensable resource offering key insights into actionable targets for basic science research, suggestions for clinical best practices and community interventions, and novel strategies and advocacy opportunities to reduce health disparities in Latino communities.
Jan 18, 2020
Tammie Quest, MD Professor of Emergency Medicine Director, Emory Palliative Care Center Emory University holds a talk on "Care of the Imminently Dying Patient" at the Stanford EM Grand Rounds Jan. 2020.
Clinical Research
Jan 16, 2020
This study aims at investigating new automatic fitting techniques for cochlear implant patients based on objective measures. For this reason, the evolution of these neurophysiological measures, expressing the encoding of pure tones and speech, will be characterized in cochlear implanted patients as a function of post-implantation time and will be compared to those of normal hearing subjects. Moreover, the effect of auditory training with new tools based on serious games will be assessed.
Jan 16, 2020
This study is designed to evaluate the efficacy and safety of acalabrutinib plus bendamustine and rituximab followed by acalabrutinib plus cytarabine and rituximab in subjects with treatment naïve mantle cell lymphoma (MCL), as a preparation for a larger cooperative group trial with the goal of achieving a standard induction regimen for MCL in transplant eligible patients. The investigators hypothesize that the addition of acalabrutinib to the BR/CR regimen will prove safe and increase the complete response (CR) rate as well as minimal residual disease (MRD) negativity pre-transplant, thus improving clinical outcomes.
Jan 16, 2020
This study is a clinical trial to assess the effectiveness of the supplement Colaren® associated with annually zoledronic acid 4mg, in the treatment of osteoporosis secondary or not to HIV infection, compared to standard treatment plus zoledronic acid 4mg/annually. The standard treatment will include 1gr of calcium/day and vitamin D supplement. In both cases, vitamin D levels will be evaluated, which should remain at more than 30 ng/mL.
Publications
Jan 18, 2020
This book provides a concise yet comprehensive overview of pediatric acute respiratory distress syndrome (PARDS). The text reviews the emerging science behind the new PARDS definition; explores the epidemiology, pathobiology, etiologies, and risk factors; reviews state-of-the-art treatment modalities and strategies; and discusses clinical outcomes.
Jan 18, 2020
This multi-faceted book provides readers with comprehensive guidance to spine pain care. This six-part reference begins with a review on the epidemiology and economic impacts that present clinical and financial challenges for spine pain care.
Jan 18, 2020
This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Advancing the Science of Cancer in Latinos proves to be an indispensable resource offering key insights into actionable targets for basic science research, suggestions for clinical best practices and community interventions, and novel strategies and advocacy opportunities to reduce health disparities in Latino communities.
Videos
Jan 18, 2020
Tammie Quest, MD Professor of Emergency Medicine Director, Emory Palliative Care Center Emory University holds a talk on "Care of the Imminently Dying Patient" at the Stanford EM Grand Rounds Jan. 2020.
Jan 17, 2020
Dr. Guze discusses digital dentistry and how it has enabled dentists to do advanced same day procedures for our dental patients. The technology allows dentists to digitally scan a tooth or teeth to help create digital impressions and this is more comfortable for the patient. Once the scan is complete a tooth can be designed while the patient is still in the chair. Within 30 minutes a crown can be created and the patient can leave the procedure the same day with a new tooth.
Jan 17, 2020
Daniel P. Petrylak, MD, discusses the recent FDA approval of the antibody drug complex enfortumab vedotin for treating refractory advanced urothelial disease in patients previously treated with immunotherapy and chemotherapy. He describes how the drug complex works to fight bladder cancer by recognizing Nectin-4, a biomarker expressed on the surface of bladder cancer cells, and delivering MMAE to cause cytotoxic activity.
Jan 17, 2020
UC Irvine's Paramjit T. Joshi, MD, talks about the decisions that impact work/life balance and some myths regarding the relationship between a mentor and a mentee.
Case Studies
Jan 18, 2020
A 17-year-old male patient with a giant osteoma in the mandibular condyle. Posttreatment post-op follow-up, post-ortho, and orthognathic surgery after dental implantation are described.
Jan 17, 2020
In this patients’ case, the recently placed PEG-tube with ascitic fluid leakage was identified as the most plausible infection source. Although a rare bacterial peritonitis pathogen, Achromobacter may be associated with wide antimicrobial resistance and unfavorable outcomes.
Jan 17, 2020
This case involves acute and follow-up imaging findings of a giant thrombosed left Middle cerebral artery aneurysm complicated by an acute stroke and discusses the value of noncontrast Susceptibility weighted imaging combined with DWI to identify the ischemic penumbra. Perfusion weighted imaging served as reference for the Susceptibility weighted imaging.
Jan 17, 2020
Familial veno-occlusive disease with immunodeficiency syndrome (VODI) is an autosomal recessive immunodeficiency syndrome. This case is of a 3-month-old baby girl of Pakistani origin with homozygous novel variant in the SP110 gene with classical phenotypic manifestations of VODI.