According to a model study, delays in cancer surgery related to the COVID-19 pandemic could substantially worsen survival outcomes. "Lockdown and redeployment due to the COVID-19 pandemic are causing significant disruption to cancer diagnosis and management," besides "A 3-month delay to surgery across all Stage 1-3 cancers is estimated to cause >4,700 attributable deaths per year in England." added a researcher.
News
May 29, 2020
A majority of women with gestational trophoblastic tumors (GTTs) who had failed on single-agent chemotherapy showed no evidence of disease after treatment with avelumab (Bavencio), a small phase II study found. Of the women who are not cured with methotrexate, this study suggests that at least half of them may be cured by giving immunotherapy subsequently to the methotrexate. To expose all the patients to an expensive immunotherapy upfront to benefit the very small proportion who won't be cured otherwise is a big leap in the wrong direction
May 29, 2020
COVID-19 and cancers of the chest cavity make a deadly combination, researchers reported at the virtual meeting of the American Society of Clinical Oncology (ASCO). The mortality rate for patients with thoracic cancer and COVID-19 was 35.5%, according to experts at Vanderbilt University Medical Center in Nashville. Of the 428 patients diagnosed with thoracic cancer and also infected with COVID-19, Horn said 169 have recovered, 119 have ongoing COVID-19 infection, and 141 died. Among those deaths, 79.4% were attributed to COVID-19 and 10.6% to the patients' progressive cancer. Another 8.5% died of a combination of cancer and COVID-19. Just 8.3% of the patients were admitted to an intensive care unit; 5% of the patients who died utilized ventilators.
Journal Abstracts
May 29, 2020
J. Stranne et.al. conducted a study to assess the objective and outcome-based facts about surgical results after radical prostatectomy as it is essential for each surgeon to improve his/her performance. The researchers concluded that the process of quality control of RP locally at Sahlgrenska University Hospital, and nationally through the National Prostate Cancer Registry, has been long but fruitful. The online design, with direct real-time feedback to the institutions that report the data, is essential.
May 29, 2020
Sandra MacDonald et.al. conducted a study to assesses predictive factors for non-sentinel nodes metastasis and validates five models predicting non-sentinel nodes metastasis. The researchers concluded that Bertolli et al. (2019) had amongst the highest overall model performance, was the most clinically meaningful and is recommended as the preferred model for predicting non-sentinel nodes metastasis.
May 29, 2020
Sandra MacDonald et.al. conducted a study to assesses predictive factors for non-sentinel nodes metastasis and validates five models predicting non-sentinel nodes metastasis. The researchers concluded that Bertolli et al. (2019) had amongst the highest overall model performance, was the most clinically meaningful and is recommended as the preferred model for predicting non-sentinel nodes metastasis.
Recent Articles
May 29, 2020
J. Stranne et.al. conducted a study to assess the objective and outcome-based facts about surgical results after radical prostatectomy as it is essential for each surgeon to improve his/her performance. The researchers concluded that the process of quality control of RP locally at Sahlgrenska University Hospital, and nationally through the National Prostate Cancer Registry, has been long but fruitful. The online design, with direct real-time feedback to the institutions that report the data, is essential.
May 29, 2020
Kirk J.Wojnoa et.al. conducted a study to evaluate whether multiplex PCR-based molecular testing is noninferior to urine culture for detection of bacterial infections in symptomatic patients. The researchers concluded that multiplex PCR is noninferior to urine culture for detection and identification of bacteria.
May 29, 2020
According to a model study, delays in cancer surgery related to the COVID-19 pandemic could substantially worsen survival outcomes. "Lockdown and redeployment due to the COVID-19 pandemic are causing significant disruption to cancer diagnosis and management," besides "A 3-month delay to surgery across all Stage 1-3 cancers is estimated to cause >4,700 attributable deaths per year in England." added a researcher.
Clinical Research
Feb 27, 2020
Christopher G. Brennan-Jones et.al. identified specific strategies which have shown effectiveness in reducing workplace noise. These include implementation of stricter legislation and also stress upon the need for training in the proper use of earplugs and earmuffs so as to reduce noise exposure to safe levels.
Feb 27, 2020
Daniel G. Whitney et.al. conducted a study to determine prevalence of major noncommunicable diseases in young adults with pediatric-onset disabilities and compared it in adults without pediatric onset disabilities. The researchers found that young adults with pediatric onset disabilities showed an early onset of several noncommunicable diseases. They were contributors to global and national burden of disease and mortality.
Jan 31, 2020
This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective in arresting or remineralizing initial interproximal lesion in comparison to SDF applied without Super Floss or fluoride varnish applied alone.
Publications
Jan 29, 2020
This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomised trials, observational studies and epidemiology.
Jan 29, 2020
Promoting rational therapy within the discipline of cardiology, the American Journal of Cardiovascular Drugs covers all aspects of the treatment of cardiovascular disorders, particularly the place in therapy of newer and established agents. Via a program of reviews and original clinical research articles, the journal addresses major issues relating to treatment of these disorders, including the pharmacology, efficacy and adverse effects of the major classes of drugs; information on newly developed drugs and drug classes.
Jan 29, 2020
Journal of Diabetes Investigation is the core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes. The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. The Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology.
Videos
May 27, 2020
Dr. Gonzalo Sapisochin presents his research using living liver transplantation as a treatment for patients with colorectal cancer that has spread to the liver. Liver transplantation is frequently used as a curative treatment for selected patients with the most common liver cancer, hepatocellular carcinoma. Dr. Sapisochin’s study is expanding liver transplantation to patients with colorectal cancer which has spread to the liver. Colorectal cancer is diagnosed in 1.8 million people every year and it is estimated that in approximately 50 percent of these cases, cancer will spread to the liver. "We think that pre-transplant chemotherapy, careful monitoring of tumors, and living donation will give our patients better results," says Dr. Sapisochin.
Jan 30, 2020
Sasikumar Kilaikode et.al. presented a talk on Neuromuscular Disorders in children with a perspective of Pulmonology with an objective to discuss respiratory patholophysilogy of neuromuscular disease in children, outlining the monitoring of pulmonary features and discussing the management of chronic respiratory failure in children with neuro-muscular disorders in children.
Jan 30, 2020
In this video Houston Methodist Hospital, Dipan J. Shah, MD, interviews Paul M. Ridker, MD discussing his Grand Rounds Conference about "Inflammation and Atherosclerosis: Where have we been? Where are we going?" This talk was presented by Houston Methodist DeBakey Heart & Vascular Center.
Jan 30, 2020
Kamal Bhsual presented a talk on Primary Hyperparathyroidism with an objective of understanding the etiology, pathophysiology, manifestations, investigations and the management. The speaker has also discussed about the cases of Normocalcemic Primary Hyperparathyroidism and the points to consider under such instances.
Case Studies
Feb 26, 2020
Isabella Aquila et.al. describe a case of Sudden death due to Takayasu’s arteritis and how histopathology came in handy by revealing eosinophilia in the aortic wall, consistent with a vasculitis such as Takayasu’s arteritis as the autopsy only showed sclerosis of the thoracic aorta, abdominal aorta and coronary arteries.
Feb 25, 2020
Shuquan Zhao et.al. presented a case of a a 21-year-old woman diagnosed with “acute gastroenteritis” who expired 4 days later. Autopsy findings revealed an inflammatory polypous embolic located at 1.0 cm from the left anterior descending branch. To find the real cause of this embolus, virus detection was performed through RT-PCR, however the findings were negative.
Feb 24, 2020
F. Coussy et al sought to determine the response to PI3K and MAPK pathway inhibitors in patient-derived xenografts of MBCs with targetable alterations. The treatment of metaplastic breast cancer PDXs by activation of the PI3K-AKT-mTOR and RTK-MAPK pathways at the genomic and protein levels with a combination of PI3K and MEK inhibitors resulted in tumor regression in mutated models and may, therefore, be of interest for therapeutic purposes.
Feb 24, 2020
Isaac Biney reported the case of a 65-year-old female with limited SSc complicated by severe PAH and a nonhealing left lower extremity venous ulcer. HBO2T was successfully used as an adjunct in her management resulting in complete resolution of the venous ulcer and improved quality of life without any adverse effects on her pulmonary arterial hypertension.