News

Oct 18, 2019

The Food and Drug Administration announced today that in the year 2019 the agency has approved about 1,171 generic drugs which is an all time record in itself. The FDA added further that Generic drugs account for about 90% of all prescription drug purchases in the U.S and this has lead to savings to the healthcare system totaling an estimated $293 billion in the past. 

Oct 18, 2019

Two studies reported at the 2019 Digestive Disease Week found that surveillance intervals often are too short, possibly putting patients at risk for harm from unnecessary interventions.

Oct 18, 2019

As the number of cases have ballooned to now 1,299 across the nation, experience has grown such that the agency released official interim guidance for clinicians on what it's now calling EVALI (e-cigarette, or vaping, product use-associated lung injury).

Journal Abstracts

Oct 19, 2019

The present study evaluated solid indeterminate nodules with radiological stability suggesting benignity (SINRSBs) through a texture analysis of computed tomography (CT) images. A total of 100 chest CT scans were evaluated, including 50 cases of SINRSBs and 50 cases of malignant nodules. kurtosis (KUR), skewness (SKW), and histogram shape can help to noninvasively diagnose SINRSBs but should not be used alone or without considering clinical data.

Oct 17, 2019

A retrospective, single-center, cross-sectional study on 72 estrogenized transgender women aimed to characterized spermatogenesis in them. It concluded that, spermatogenesis is preserved in approximately 40% of these individuals. Duration of hormonal therapy did not affect the degree of preservation of germ cells or spermatogenesis but starting hormonal treatment at a younger age may be associated with decreased germ cells in the testicle. The volume of testicles predict presence of preserved spermatogenesis.

Oct 17, 2019

In a cohort study of 82 232 participants, personality traits in adolescence were a factor associated with incident dementia almost 5 decades later in a national US cohort. Calm and mature adolescents were less likely to develop dementia, and this risk reduction was significantly more pronounced with higher socioeconomic status.

Recent Articles

Oct 19, 2019

This issue of Hand Clinics, guest edited by Drs. Sandeep Sebastin and David Tan, will cover key topics of importance for Soft Tissue Reconstruction for Digital Defects. This issue is one of four selected each year by our series consulting editor, Dr. Kevin Chung. Topics discussed in this issue will include: Vascular Anatomy of the Hand in relation to flaps, Adipofascial Flaps, Transposition and Rotation Flaps, etc.

Oct 19, 2019

This new book covers all aspects of “obesity surgery” under emergency conditions. It describes the frailty of obese patients and the critical care needs in emergency conditions and examines clinical pictures, the indications for surgery and the surgical approach in obese patients in emergency conditions in the general clinical setting and after bariatric surgery.

Oct 19, 2019

This atlas provides up-to-date guidance on techniques for immediate loading of dental implants. It highlights key points in immediate implant loading of full-arch prostheses and describes the latest procedures for impression and measurement taking.

Clinical Research

Oct 18, 2019

The purpose of this observational study is to develop a registry to collect long-term data on patients with pediatric cutaneous mastocytosis and develop better knowledge of the timing, symptoms, resolution or progression of the disease, and predictive markers of its severity.

Oct 18, 2019

The purpose of this investigation is to determine the safety and preliminary efficacy of implanting a cochlear implant (CI) in the profoundly deaf ear of an adult with one normal hearing (NH) ear (termed "single-sided deaf" person, or SSD). The potential subjects will have been deafened post-lingually, thus, at one point the now deafened ear did conduct sound from the periphery. The MED-EL Maestro CI system will be implanted in ten (10) SSD patients. The long-term goal of this research program is to determine whether the CI, in combination with the NH ear, may provide improved localization ability and better speech understanding in noise, relative to performance before cochlear implantation.

Oct 18, 2019

The ATR(ataxia-telangiectasia and Rad3 related protein) inhibitor BAY1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas. The purpose of the proposed trial is to evaluate the safety and tolerability of BAY1895344, and to identify the maximum tolerated a dose of BAY1895344 that could be safely given to cancer patients. Further, the response of cancer to the treatment will be determined.

Oct 18, 2019

The ATR(ataxia-telangiectasia and Rad3 related protein) inhibitor BAY1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas. The purpose of the proposed trial is to evaluate the safety and tolerability of BAY1895344, and to identify the maximum tolerated a dose of BAY1895344 that could be safely given to cancer patients. Further, the response of cancer to the treatment will be determined.

Oct 18, 2019

This pilot study is designed to determine if the rehabilitative benefits of continuous passive motion (CPM) will help preserve/restore the joint function and significantly improve the rate of recovery of patients after the surgical release of elbow contractures better than standard physiotherapy and static splinting.

Oct 16, 2019

A clinical trial to assess the efficacy, safety, and tolerability of mirabegron versus placebo in men with overactive bladder (OAB) symptoms while taking tamsulosin hydrochloride for lower urinary tract symptoms (LUTS) due to Benign Prostatic Hyperplasia (BPH).

Oct 16, 2019

Researchers at the University of Kentucky are conducting a study to learn how two different medications that are used to treat opioid use disorder affect the health of patients who are HIV-positive.

Publications

Oct 19, 2019

This atlas provides up-to-date guidance on techniques for immediate loading of dental implants. It highlights key points in immediate implant loading of full-arch prostheses and describes the latest procedures for impression and measurement taking.

Oct 19, 2019

This book is the only text for steroid profile interpretation and contains graphic representations and illustrations. It utilises unique reference data collected over 30 years of clinical practice

Oct 19, 2019

The first book to bring together the innovations gained from positive psychology, psychotherapy, and psychiatry. It is written by global experts in positive mental health.

Oct 19, 2019

This issue of Hand Clinics, guest edited by Drs. Sandeep Sebastin and David Tan, will cover key topics of importance for Soft Tissue Reconstruction for Digital Defects. This issue is one of four selected each year by our series consulting editor, Dr. Kevin Chung. Topics discussed in this issue will include: Vascular Anatomy of the Hand in relation to flaps, Adipofascial Flaps, Transposition and Rotation Flaps, etc.

Oct 19, 2019

This new book covers all aspects of “obesity surgery” under emergency conditions. It describes the frailty of obese patients and the critical care needs in emergency conditions and examines clinical pictures, the indications for surgery and the surgical approach in obese patients in emergency conditions in the general clinical setting and after bariatric surgery.

Oct 16, 2019

The Annals of Pediatric Cardiology is based on the idea of providing a common platform for presenting data and expressing views for members of the following specialties viz. cardiology, cardiac surgery, anesthesiology, intensive care as well as more basic disciplines of pathology, molecular biology and genetics.

Oct 16, 2019

CHEST features the best in peer-reviewed, cutting-edge original research in the multidisciplinary specialties of chest medicine: pulmonary, critical care, and sleep medicine; thoracic surgery; cardiorespiratory interactions; and related disciplines. It is home to highly regarded clinical practice guidelines and consensus statements.

Videos

Oct 18, 2019

Fusionless surgery coupled with growing rod techniques is increasingly advocated for the treatment of early-onset scoliosis in general and neuromuscular scoliosis in particular. Iliosacral screws have excellent biomechanical characteristics but are hard to place safely. Here, the authors report on robot-assisted iliosacral screw positioning as part of growing rod surgery for the fusionless correction of early-onset scoliosis. The technique is based on a bilateral double sliding rod construct anchored to the pelvis proximally with 6 hooks or sublaminar bands and distally with iliosacral screws placed by the robot.

 

Oct 18, 2019

 

Watch Dr. Francesco Coratti, MD et al surgically address a rectovaginal fistula using a TEO approach. The person had had a prior TME after neoadjuvant therapy for rectal cancer. 

Oct 18, 2019

This video demonstrates Total Laparoscopic Hysterectomy for Very Large Uterus with Huge Fibroid. It is not uncommon for a laparoscopic surgeon to be able to perform the entire laparoscopic hysterectomy using a few 10mm and 5-mm ports and then a larger abdominal incision to remove the surgical specimen using morcellator. In conclusion, this video shows that the size of the uterus does not forbid the laparoscopic approach for hysterectomy.

Oct 18, 2019

Watch Dr. Sadeer B Hannush MD, Wills Eye Institute discuss amniotic membrane transplantation indication and techniques.

Case Studies

Oct 18, 2019

This is a a case of thoracic spinal Atypical teratoid rhabdoid tumors in a three-year-old boy who presented with a ten-day history of back pain and progressive weakness of the lower extremities and an inability to walk. The tumor showed characteristic aggressive progression until managed with intensive multimodal therapy to achieve durable long-term remission. 

Oct 18, 2019

 A 43-year-old man in 2014 was diagnosed with oral squamous cell carcinoma involving the tongue. He underwent extensive surgery that involved right tongue cancer resection and reconstruction with a free flap graft from his right forearm. He then was started on chemotherapy and radiation. A biopsy of the mass revealed metastatic squamous cell carcinoma. He was deemed to not be a surgical candidate and continued on palliative chemotherapy. 

Oct 18, 2019

A 50-year-old male with a history of hyperthyroidism, hypertension, and congestive heart failure presented to another hospital with fever and altered mentation. He was found to have pneumonia on imaging and was started on antibiotics. He developed shock complicated by atrial fibrillation with rapid ventricular rate which was treated with amiodarone. The endocrinology team determined he was in thyroid storm. His medical treatment of thyroid storm was aggressively titrated to maximal therapy. But this was followed by transaminitis, respiratory failure requiring intubation, shock requiring vasopressor support, kidney failure requiring continuous renal replacement therapy, and heart failure.

Oct 18, 2019

An 85-year-old male patient presented for investigation of iron deficiency anaemia. Initial upper endoscopy found a subepithelial duodenal lesion with central depression but otherwise normal appearing mucosa. Superficial biopsies of the duodenal lesion were unremarkable. Subsequent antegrade single balloon enteroscopy revealed active bleeding from the lesion which was refractory to endoscopic treatment.