News

Jan 18, 2020

Fewer than half of clinical trial sponsors reported their results to a U.S. government registry within a year of the trial’s completion, flouting U.S. law and risking fines, British researchers reported. In a study they found that in spite of legal efforts to curb well-documented lapses in reporting of negative trial results, many sponsors are still not reporting their findings, potentially keeping patients and doctors in the dark about benefits and side effects of treatments.

Jan 17, 2020

According to new findings in the American Heart Association's journal Circulation: Cardiovascular Quality and Outcomes - too few people covered by Medicare participated in outpatient cardiac rehabilitation after a heart attack or acute heart event or surgery, particularly women, the elderly and non-white patients. Outpatient cardiac rehabilitation has been shown to improve health outcomes among patients who have heart failure, have suffered heart attacks or have undergone a cardiac procedure such as coronary artery bypass surgery.

Jan 17, 2020

The novel 2HELPS2B score is useful for predicting inpatient seizure risk and determining appropriate continuous EEG monitoring durations, researchers report. Only 1 hour of screening EEG is needed to accurately calculate the 2HELPS2B score. They hope this result make 2HELPS2B more clinically useful. Dr. Struck and colleagues used machine-learning methods to develop the 2HELPS2B scoring system with the goal of improving seizure prediction. It incorporates 5 EEG features and a single clinical factor (prior seizure).

Journal Abstracts

Jan 16, 2020

The aim of this prospective study was to evaluate natural colicin and microcin production by large intestinal mucosal bacteria in each stage of colorectal neoplasia and in those with a history of colorectal neoplasia. Strains isolated from large intestinal mucosa in patients with colorectal neoplasia produce colicins and microcins more frequently compared to controls. Bacteriocin production does not differ between patients with current and previous colorectal neoplasia. Fundamental differences in bacteriocin production have been confirmed between males and females.

Jan 16, 2020

Cristina SilvaMeira-Strejevitch et al obtained plasma samples from 51 patients with ocular toxoplasmosis (OT Group), 26 people with asymptomatic toxoplasmosis (AT Group), and 25 healthy people seronegative for toxoplasmosis (NC Group) in this study, to assess gene expression of microRNA (miR)-155-5p, miR-146a-5p, miR-21-5p, miR-29c-3p and miR-125b-5p in these samples. According to the findings, compared with AT people, OT patients had up-expressed miR-155-5p and miR-29c-3p. In OT patients, down-expressed miR-21-5p and miR-125b-5p were detected. Differences were statistically significant. Experts noted a similar miR-146a-5p expression in OT patients and AT people, without significant difference. These findings were verified in comparative analysis for microRNA (miRNA) levels between AT and OT groups. The circulating miRNA levels in ocular toxoplasmosis were assessed for the first time ever in this study.

Jan 16, 2020

Bei Shi et al examined if women with polycystic ovary syndrome (PCOS) exhibit altered fructose levels. At Shengjing Hospital of China Medical University, they recruited a total of 157 Chinese Han women (67 controls and 90 PCOS patients). Measurement of fructose levels was done in serum samples obtained from 80 patients with PCOS (32 lean, 48 overweight/obese) and 59 control women (27 lean, 32 overweight/obese) and in follicular fluid samples obtained from mature follicles (17–22 mm) and matched immature follicles (8–13 mm) from 10 patients with PCOS and 8 control women. As per outcomes, the Chinese Han women with overweight/obesity and hyperinsulinemia exhibit a correlation of elevated serum fructose levels with PCOS. Follicular fluids from PCOS patients exhibit higher fructose levels than from control women.

Recent Articles

Jan 18, 2020

This multi-faceted book provides readers with comprehensive guidance to spine pain care. This six-part reference begins with a review on the epidemiology and economic impacts that present clinical and financial challenges for spine pain care.

Jan 18, 2020

This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Advancing the Science of Cancer in Latinos proves to be an indispensable resource offering key insights into actionable targets for basic science research, suggestions for clinical best practices and community interventions, and novel strategies and advocacy opportunities to reduce health disparities in Latino communities. 

Jan 18, 2020

Tammie Quest, MD Professor of Emergency Medicine Director, Emory Palliative Care Center Emory University holds a talk on "Care of the Imminently Dying Patient" at the Stanford EM Grand Rounds Jan. 2020.

Clinical Research

Jan 16, 2020

This study aims at investigating new automatic fitting techniques for cochlear implant patients based on objective measures. For this reason, the evolution of these neurophysiological measures, expressing the encoding of pure tones and speech, will be characterized in cochlear implanted patients as a function of post-implantation time and will be compared to those of normal hearing subjects. Moreover, the effect of auditory training with new tools based on serious games will be assessed.

Jan 16, 2020

This study is designed to evaluate the efficacy and safety of acalabrutinib plus bendamustine and rituximab followed by acalabrutinib plus cytarabine and rituximab in subjects with treatment naïve mantle cell lymphoma (MCL), as a preparation for a larger cooperative group trial with the goal of achieving a standard induction regimen for MCL in transplant eligible patients. The investigators hypothesize that the addition of acalabrutinib to the BR/CR regimen will prove safe and increase the complete response (CR) rate as well as minimal residual disease (MRD) negativity pre-transplant, thus improving clinical outcomes.

Jan 16, 2020

This study is a clinical trial to assess the effectiveness of the supplement Colaren® associated with annually zoledronic acid 4mg, in the treatment of osteoporosis secondary or not to HIV infection, compared to standard treatment plus zoledronic acid 4mg/annually. The standard treatment will include 1gr of calcium/day and vitamin D supplement. In both cases, vitamin D levels will be evaluated, which should remain at more than 30 ng/mL.

Jan 16, 2020

This study is a clinical trial to assess the effectiveness of the supplement Colaren® associated with annually zoledronic acid 4mg, in the treatment of osteoporosis secondary or not to HIV infection, compared to standard treatment plus zoledronic acid 4mg/annually. The standard treatment will include 1gr of calcium/day and vitamin D supplement. In both cases, vitamin D levels will be evaluated, which should remain at more than 30 ng/mL.

Jan 16, 2020

The purpose to determine the efficacy and safety of conventional treatment combined with or without Xiyanping injection in the treatment of pediatric bronchitis and to further evaluate the clinical value of Xiyanping injection in shortening the course of pediatric bronchitis. The study will enroll 240 Pediatric bronchitis volunteers, who will be randomized into 2 groups (1:1 ratio): volunteers from the first group will receive Routine treatment for pediatric bronchitis and Xiyanping injection; volunteers from the second group will receive Routine treatment for pediatric bronchitis. Xiyanping injection will be administered as an intravenous injection of 0.2-0.4mL/kg/day once daily for 5 days concomitantly with Routine treatment for pediatric bronchitis.

Jan 15, 2020

Comparison is made between standard nasotracheal tubes and a specially designed nasotracheal tube during nasotracheal intubation in children undergoing general anesthesia for dental surgery.

Jan 15, 2020

The study's aim is to evaluate the pharmacokinetics and safety of copanlisib in subjects with impaired hepatic or renal function in comparison to healthy subjects.

Publications

Jan 18, 2020

This book provides a concise yet comprehensive overview of pediatric acute respiratory distress syndrome (PARDS). The text reviews the emerging science behind the new PARDS definition; explores the epidemiology, pathobiology, etiologies, and risk factors; reviews state-of-the-art treatment modalities and strategies; and discusses clinical outcomes.

Jan 18, 2020

This multi-faceted book provides readers with comprehensive guidance to spine pain care. This six-part reference begins with a review on the epidemiology and economic impacts that present clinical and financial challenges for spine pain care.

Jan 18, 2020

This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Advancing the Science of Cancer in Latinos proves to be an indispensable resource offering key insights into actionable targets for basic science research, suggestions for clinical best practices and community interventions, and novel strategies and advocacy opportunities to reduce health disparities in Latino communities. 

Jan 18, 2020

This volume addresses three general themes in the preoperative diagnosis of early-stage esophagus cancer starting. Beginning with detailed observations of diagnosis using Endoscopic Submucosal Dissection (ESD), subsequent sections describe the current medical treatments for various types of carcinoma and conclude with detailed explanations of difficult cases and their diagnoses. The book also includes a wealth of endoscopic and pathological figures, helping scholars understand the diagnosis and treatment visually.

Jan 17, 2020

The sixth edition of Contact Dermatitis covers in detail every conceivable aspect of irritant and allergic contact dermatitis and its modern-day management. In this new edition, special emphasis is given to immunological mechanisms, molecular aspects of sensitizers, atypical clinical forms, patch test methodology, reactions to medicaments, and occupational and environmental factors.

Jan 15, 2020

Paediatric and Perinatal Epidemiologyis an international, peer reviewed journal that crosses the boundaries between epidemiologists, paediatricians, developmental psychologists, environmental specialists, obstetricians, child health specialists and genetic epidemiologists. Its main focus is to ensure that the most important paediatric, reproductive, obstetric and perinatal studies reach those researchers and clinicians for whom the results are especially relevant. 

Jan 15, 2020

Interventional Cardiology Clinics is a comprehensive review source, offering deeper coverage of interventional procedures for those in the field of cardiology. Written by key opinion leaders and published quarterly, these clinical reviews help interventionalists apply the latest advances to their practice. Interventional Cardiology Clinics includes systematic coverage of all of the major subject areas in the field, including percutaneous treatment of valvular heart disease, chronic total occlusion, bypass graft lesions/coronary thrombus, percutaneous ventricular support devices, and much more.

Videos

Jan 18, 2020

Tammie Quest, MD Professor of Emergency Medicine Director, Emory Palliative Care Center Emory University holds a talk on "Care of the Imminently Dying Patient" at the Stanford EM Grand Rounds Jan. 2020.

Jan 17, 2020

Dr. Guze discusses digital dentistry and how it has enabled dentists to do advanced same day procedures for our dental patients. The technology allows dentists to digitally scan a tooth or teeth to help create digital impressions and this is more comfortable for the patient. Once the scan is complete a tooth can be designed while the patient is still in the chair. Within 30 minutes a crown can be created and the patient can leave the procedure the same day with a new tooth.

Jan 17, 2020

Daniel P. Petrylak, MD, discusses the recent FDA approval of the antibody drug complex enfortumab vedotin for treating refractory advanced urothelial disease in patients previously treated with immunotherapy and chemotherapy. He describes how the drug complex works to fight bladder cancer by recognizing Nectin-4, a biomarker expressed on the surface of bladder cancer cells, and delivering MMAE to cause cytotoxic activity.

Jan 17, 2020

UC Irvine's Paramjit T. Joshi, MD, talks about the decisions that impact work/life balance and some myths regarding the relationship between a mentor and a mentee.

Case Studies

Jan 18, 2020

A 17-year-old male patient with a giant osteoma in the mandibular condyle. Posttreatment post-op follow-up, post-ortho, and orthognathic surgery after dental implantation are described.

Jan 17, 2020

In this patients’ case, the recently placed PEG-tube with ascitic fluid leakage was identified as the most plausible infection source. Although a rare bacterial peritonitis pathogen, Achromobacter may be associated with wide antimicrobial resistance and unfavorable outcomes.

Jan 17, 2020

This case involves acute and follow-up imaging findings of a giant thrombosed left Middle cerebral artery aneurysm complicated by an acute stroke and discusses the value of noncontrast Susceptibility weighted imaging combined with DWI to identify the ischemic penumbra. Perfusion weighted imaging served as reference for the Susceptibility weighted imaging.

Jan 17, 2020

Familial veno-occlusive disease with immunodeficiency syndrome (VODI)  is an autosomal recessive immunodeficiency syndrome. This case is of a 3-month-old baby girl of Pakistani origin with homozygous novel variant in the SP110 gene with classical phenotypic manifestations of VODI.