News

Apr 19, 2019

A new UCLA research suggests that one can save costs for patients and resources of hospitals by eliminating unnecessary procedures before cataract surgery. The researchers added when the doctors did not opt for chest X-rays, electrocardiograms and other preoperative procedures with no significant relation with Cataract surgery- the amount of money saved added up to $67,241 over a period of three years at a medical centre. 

Apr 18, 2019

The neuropeptide oxytocin blocks enhanced drinking in alcohol-dependent rats, according to a study led by researchers at the National Institutes of Health, and The Scripps Research Institute. Targeting the oxytocin system, the authors note, may provide novel pharmaceutical interventions for the treatment of alcohol-use disorder.

Apr 18, 2019

According to a new study by Washington University School of Medicine in St. Louis, the new rules for reimbursement are capable of providing a little relief to safety-net hospitals by shifting the burden towards wealthier patient populations. The new rules divide hospitals into five groups based on the proportion of their Medicare patients who are also enrolled in Medicaid. 

Journal Abstracts

Apr 19, 2019

The study aims to report an experience with loop underlay tympanoplasty, a modification of the underlying technique previously reported, for the reconstruction of anterior, subtotal or total tympanic membrane perforations. The loop underlay technique combines the advantages of both underlay and overlay techniques with excellent postoperative outcomes.

Apr 19, 2019

Here Bronte, et al. retrospectively analyzed ER, PgR, and AR expression on a case series of 159 specimens of primary BC samples by using immunohistochemistry and 89 patients of these had luminal tumors for which AR and ER expression and survival data were available. For twenty-four patients both primary and metastatic tumors were available.  In conclusion, these findings indicate that a prospective study is needed to better clarify the role of AR/ER ratio in different BC settings (i.e., adjuvant and metastatic). The relation between AR and PgR has to be better understood even if our findings suggest that a high AR/PgR ratio in luminal tumors is prognostically unfavorable and could be used as an additional risk-stratification marker. 

Apr 19, 2019

This study is aimed to evaluate the safety, tolerability and efficacy of nintedanib switched from pirfenidone in patients with idiopathic pulmonary fibrosis (IPF). A high incidence of early termination of nintedanib was noted when patients were switched from pirfenidone. Anorexia and weight loss during prior pirfenidone administration may increase the rate of the early termination of subsequent nintedanib treatment.

Recent Articles

Apr 19, 2019

This multicenter retrospective study is to describe the various presentations and identify predictive factors of death in patients with Calciphylaxis (CPX). Cerium nitrate may lead to vascular decalcification and chelation of reactive oxygen species, and prevent infection. Cerium nitrate-silver sulfadiazine was associated with better outcomes and should be tested in a prospective comparative trial in CPX patients.

Apr 19, 2019

The study aims to report an experience with loop underlay tympanoplasty, a modification of the underlying technique previously reported, for the reconstruction of anterior, subtotal or total tympanic membrane perforations. The loop underlay technique combines the advantages of both underlay and overlay techniques with excellent postoperative outcomes.

Apr 19, 2019

A prospective, longitudinal, descriptive study was conducted from January 2016 to January 2018 to detect nerve dysfunction after hip arthroscopy. A total of 110 patients were included.  Twenty-four hours after surgery, 62.7% reported symptoms of abnormal sensation at least in one area. Nerve dysfunction after HA was more common than has been reported in the literature within large populations. Traction time was a significant factor in the development of perineal nerve dysfunction.

Clinical Research

Apr 19, 2019

This is an open-label, multi-dose, single-arm, multi-center, Phase 1, dose-escalation study to define a maximum tolerated dose and schedule (MTDS), describe preliminarily safety, and to assess PK, immunogenicity, immunomodulatory activity, and potential anti-tumor activity of MGD006 in patients with AML or MDS whose disease is not expected to benefit from cytotoxic chemotherapy. The primary goal of this Phase 1, dose-escalation study, is to determine the maximum tolerated dose level of MGD006 in patients with AML and MDS whose disease is not expected to benefit from cytotoxic chemotherapy.

Apr 19, 2019

This clinical study is researching a new technology to treat a specific type of knee cartilage injuries. The study is comparing their product and technique to a standardized and regularly performed procedure. Patients who qualify for this trial will receive all study related medication and care at no cost to them or their insurance company. The study is covering the entire cost of surgery for patients who qualify.

Apr 19, 2019

This study evaluates the ability of the drug sildenafil to improved exercise capacity, cardiac performance during exercise, and quality of life in patients with moderate to severe CF lung disease. 3/4 of the subjects will receive sildenafil and 1/4 will receive a placebo.

Apr 18, 2019

This study will serve as a pilot study to determine the efficacy and safety of two novel oral agents (clonidine, naltrexone) in the treatment of chronic, non-experimentally induced itch in atopic dermatitis. In this study, eight subjects with symptomatic atopic dermatitis will be recruited and treated with either oral clonidine (four subjects) or oral naltrexone (four subjects). Disease burden will be evaluated before and after 4 weeks of treatment through reporting of subjective symptomatology via surveys/questionnaire, neurometer study, and clinical assessment.

Apr 18, 2019

The purpose of this study is to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06817024 in healthy volunteers, in participants with chronic rhinosinusitis, with nasal polyps and in participants with moderate-to-severe Atopic Dermatitis. This is a phase 1, randomized, double-blind, third-party open, placebo-controlled, dose escalating study.

Apr 16, 2019

This study is designed to treat your disease with an autologous stem cell transplant using a regimen of immune suppressant drugs and chemotherapy to reset your immune system and to determine if your disease will go into long-term remission.

Apr 16, 2019

To determine the safety and efficacy of intravitreal Aflibercept (Eylea) injection in patients with diabetic retinopathy in the prevention of macular edema following cataract surgery.

Publications

Apr 17, 2019

Pediatric Diabetes is the leading vehicle for international dissemination of research and practice relating to diabetes in youth. It publishes articles on epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes in childhood and adolescence. The current issue consists of articles on Children with Type-1 Diabetes, glucose monitoring methods of continuous glucose monitoring etc. 

Apr 17, 2019

Cardiology in the Young is devoted to cardiovascular issues affecting the young, and the older patient suffering the sequels of congenital heart disease, or other cardiac diseases acquired in childhood. The journal serves the interests of all professionals concerned with these topics. 

Apr 17, 2019

Obesity Facts publishes articles covering all aspects of obesity, in particular epidemiology, etiology and pathogenesis, treatment, and the prevention of adiposity. All professionals concerned with obesity issues will find this journal a most valuable update to keep them abreast of the latest scientific developments.

Apr 17, 2019

Journal of Crohn's and Colitis is a monthly peer reviewed journal publishing latest researches and current updates in the flied of Gastroenterology. This month's issue consists of articles like Capsule endoscopy of the small bowel, Adalimumab monotherapy versus combination therapy with immunomodulators, combination therapy for IBD patients etc. 

Apr 17, 2019

Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior.

Apr 16, 2019

It will serve as an authoritative reference text for doctors, students and allied health professionals who would like to learn more about the new technique of uniportal VATS. This introduces the history, development and current status of uniportal VATS by pioneers and authorities of this technique. The highly illustrated content in the chapters enhances readers to rapidly understand the techniques of uniportal VAT. The use of video clips adds value to the learning experience and applicability of the techniques.

Apr 16, 2019

This text provides a state-of-the-art overview of Non-Hodgkin's lymphoma (NHL) in children and adolescents. The volume is divided into seven sections, each of which focuses on a critical component of pediatric NHL, including history and epidemiology, pathology and molecular biology, disease evaluation and response, common and rare sub-types of NHL, and current and novel treatment strategies. The text also comprehensively reviews the late effects of treatment, quality of patient life, and NHL treatment in countries with limited resources.

Videos

Apr 18, 2019

Scientists have uncovered a molecular signaling pathway involving Stat3 and Fam3a proteins that regulates how muscle stem cells decide whether to self-renew or differentiate - an insight that could lead to muscle-boosting therapeutics for muscular dystrophies or age-related muscle decline

Apr 18, 2019

Sasikumar Kilaikode from LSU Health Shreveport presented a talk on Obstructive Sleep Apnea in children, with respect to identifying its signs and early intervention in order to prevent complications. 

Apr 18, 2019

Sumeet Singh Miiter from  Icahn School of Medicine presented a talk on Cardiac Amyloidosis with respect to recognising burden and different causes of heart failure with preserved ejection fracture, discussing novel diagnostics and therapeutics for cardiac amyloidosis. 

Apr 18, 2019

Zachary Bloomgarden from Icahn School of Medicine presented a talk on HbA1c in Diabetes Management with respect to quantitating glycemic exposure, Glycemic variability and managing outcomes related to glycemia. 

Case Studies

Apr 19, 2019

A 14-year-old adolescent with short stature and delayed puberty, was admitted in a Paediatric Endocrinology outpatient clinic. His familial target height was on percentile 3–10.  After a careful investigation, he was found to have a 45,X/46,X,idic(Y)(p11.32) mosaicism. 

Apr 19, 2019

A 38-year-old with sickle cell disease-associated Pulmonary hypertension and acute chest syndrome was successfully managed with inhaled and oral pulmonary vasodilators in the setting of persistent elevations in pulmonary vascular resistance leading to acute RV failure and cardiogenic shock. 

Apr 19, 2019

A 35-year-old patient was admitted to endocrinology outpatient department with complaint of pain in the neck. Physical examination revealed 2 cm nodule on the thyroid right lobe. Serum thyroid hormone levels were within normal range. Ultrasonography revealed a 23x15 mm hypoechoic nodule with micro calcifications and cystic areas on the right lobe. 

Apr 19, 2019

 A 63-year-old male with severe iron deficiency anemia on biweekly intravenous iron infusions and weekly packed red blood cell transfusions presented with melena over several months. Upper endoscopy demonstrated a clean-based gastric body ulcer and nonbleeding gastric varices. Histology of the gastric ulcer was suggestive of iron-induced gastric mucosal injury.