In a phase 3 trial, first-line tebentafusp has been demonstrated to have an overall survival of 21.7 months in patients with metastatic uveal melanoma; longer than with immunotherapy or chemotherapy. Tebentafusp is a bispecific fusion protein that targets gp100 through a high affinity T-cell receptor binding domain and an anti-CD3 T-cell engaging domain. The limitation with tebentafusp is that it can only be used to treat HLA-A*02:01-positive patients as the T-cell receptor binding domain only recognizes a specific gp100-derived peptide presented on HLA-A*02:01.
News
Apr 20, 2021
According to a new study, periodontitis is associated with significantly higher blood pressure in otherwise healthy individuals. "Oral diseases are often overlooked and only when acute problems arise do they trigger a visit to the dentist," said senior study author Francesco D'Aiuto, head of the Periodontology Unit at the University College London Eastman Dental Institute, in the UK.
Apr 20, 2021
In a phase 3 trial, first-line tebentafusp has been demonstrated to have an overall survival of 21.7 months in patients with metastatic uveal melanoma; longer than with immunotherapy or chemotherapy. Tebentafusp is a bispecific fusion protein that targets gp100 through a high affinity T-cell receptor binding domain and an anti-CD3 T-cell engaging domain. The limitation with tebentafusp is that it can only be used to treat HLA-A*02:01-positive patients as the T-cell receptor binding domain only recognizes a specific gp100-derived peptide presented on HLA-A*02:01. Pyrexia, pruritus and rash are the most common adverse effects associated with the use of tebentafusp.
Journal Abstracts
Apr 20, 2021
Richard Gale et al. sought to examine whether anti-vascular endothelial growth factor for the treatment of macular oedema secondary to branch retinal vein occlusion is as beneficial in the real world as was demonstrated in clinical trials. Data from 5661 treatment-naive patients who either underwent anti-vascular endothelial growth factor therapy (anti-VEGF), intravitreal dexamethasone, or macular laser show that visual acuity improvements were higher and more sustained with anti-VEGF.
Apr 20, 2021
Richard Gale et al. sought to examine whether anti-vascular endothelial growth factor for the treatment of macular oedema secondary to branch retinal vein occlusion is as beneficial in the real world as was demonstrated in clinical trials. Data from 5661 treatment-naive patients who either underwent anti-vascular endothelial growth factor therapy (anti-VEGF), intravitreal dexamethasone, or macular laser show that visual acuity improvements were higher and more sustained with anti-VEGF.
Apr 19, 2021
Luis P. Braz et al. conducted a study to evaluate the prevalence of neuromuscular junction (NMJ) abnormalities in patients with mitochondrial disease. The study involved clinical and neurophysiologic testing of 80 patients with genetically proven mitochondrial disease. The study found an overall prevalence of 25.6% of neuromuscular transmission defects and NMJ abnormalities were strongly associated with coexistent myopathy, but not with neuropathy.
Recent Articles
Apr 20, 2021
Flavia Lamberghini et.al. conducted a study to investigate the positivity rate of asymptomatic SARS-CoV-2 infection in pediatric dental patients. The researches concluded that although the yield of testing was low, the systematic evaluation of asymptomatic pediatric dental cases via PCR resulted in the identification of SARS-CoV-2 carriers who could have been infectious.
Apr 20, 2021
Rim Kallala et.al. presented a reviewe of a 34-year healthy female patient who consulted for rehabilitation of the left first lower molar. The purpose of this paper was to detail the protocol of chairside system and provide a useful evaluation tool, through a clinical case carried out in the dental clinic of the Faculty of Dental Surgery Paul Sabatier Toulouse.
Apr 20, 2021
PreserFlo, made from SIBS, when implanted intraoperatively with 0.2 mg/mL to 0.4 mg/mL mitomycin C has been found to reduce IOP in patients with primary open-angle glaucoma. In a study, a reduction in IOP from 21.1 mm Hg to 14.2 mm Hg at month 12 could be achieved with the use of the device. Owing to the smoother bleb and its more posterior position, the associated risk for fibrosis, ocular surface issues and late-onset bleb complications is low.
Clinical Research
Jun 01, 2020
The purpose of this study is to find the most effective dose of radiation therapy to give to breast tumors in a shorter period of time, prior to standard partial mastectomy/axillary surgery.
Jun 01, 2020
This research study is being done to understand how patients with chronic cancer pain take their long-acting opioid medications and to develop an intervention to enhance cancer pain management.
Feb 27, 2020
Christopher G. Brennan-Jones et.al. identified specific strategies which have shown effectiveness in reducing workplace noise. These include implementation of stricter legislation and also stress upon the need for training in the proper use of earplugs and earmuffs so as to reduce noise exposure to safe levels.
Publications
Jun 26, 2020
In patients with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), a once-daily oral regimen of ibrutinib and venetoclax was associated with deep molecular remissions in both bone marrow and peripheral blood, including in patients with high-risk disease, according to investigators in phase 2 CAPTIVATE MRD trial.
Jun 04, 2020
Georgios Tsakonas et.al. conducted a study to understand the alterations in gene expression in brain metastasis versus primary tumour as it may increase aggressiveness and impair therapeutic efforts. The researchers concluded identified a unique gene downregulation pattern in brain metastases compared with primary tumours. This finding may explain the lower intracranial efficacy of systemic therapy, especially immunotherapy, in brain metastasis of patients with non–small-cell lung cancer.
Jun 01, 2020
Advance in Cancer Prevention addresses all types of cancer, how cancer forms in the body, and their prevention. It focuses on Cancer Vaccines, Chemotherapy, Radioactive Iodine Therapy, Breast Reconstruction Surgery, Mammography, Chemoprevention, aromatase inhibitors, Scintimammography, Oncoplastic surgery, Sumoylation, Dietary Supplements, Cancer Screening, Cancer and Nutrition, Exercise and Cancer, Alternative Cancer Medicines, Stem cell transplants for cancer prevention, Naturopathic Treatments, Clinical Naturopathy, Cancer Prevention from nuts.
Videos
Oct 21, 2020
A 30-year-old female presented with rapid onset of acute dysarthria and left oculomotor paralysis. The MRI showed ruptured anterior midbrain cavernoma. A conservative approach was adopted as the patient was stable. However, one month later she experienced a new bleed with right hemiparesis, diplopia and severe dysarthria. The haemorrhage extended to the surface of the midbrain anteriorly and extended posteriorly without reaching the surface of the safe entry zone. The approach to a cavernous malformation via safe zones are not always feasible due to the proximity of several critical neural structures as in this case. The resection via a posterolateral route using the supracerebellar infratentorial approach was performed successfully.
Oct 21, 2020
A 30-year-old female presented with rapid onset of acute dysarthria and left oculomotor paralysis. The MRI showed ruptured anterior midbrain cavernoma. A conservative approach was adopted as the patient was stable. However, one month later she experienced a new bleed with right hemiparesis, diplopia and severe dysarthria. The haemorrhage extended to the surface of the midbrain anteriorly and extended posteriorly without reaching the surface of the safe entry zone. The approach to a cavernous malformation via safe zones are not always feasible due to the proximity of several critical neural structures as in this case. The resection via a posterolateral route using the supracerebellar infratentorial approach was performed successfully.
Jul 17, 2020
As many as half of patients diagnosed with metastatic HER2-positive breast cancer will see their cancer spread to their brain. Though brain metastases, or "Brain Mets," are rare, they are exceedingly difficult to treat, so these patients experience poor outcomes. At this year’s ASCO meeting, Dr. Nancy Lin of Dana-Farber Cancer Institute presented promising results from the HER2CLIMB trial for these patients. In this video BCRF talks with Dr. Lin about her research focus, Brain Mets, and HER2CLIMB’s findings.
Jul 10, 2020
Watch Dr. Jamie Studts discuss the quality implementation of lung cancer screening and share his thoughts on optimizing community-based implementation.
Case Studies
Apr 20, 2021
Nadia Ansari et al. report the case of a 5-month-old boy who presented with esotropia of the right eye. He was seen to have light perception vision in the right eye and normal fix and follow vision in the left eye on examination. In addition to that, slightly pale optic nerves and multiple atrophic and hyperpigmented lesions were seen along the vascular arcades and maculae in both eyes. A head CT scan revealed regions of volume loss within the cerebral hemispheres and supratentorial white matter along with multiple foci of dystrophic calcification. On obtaining a history of exposure to rodents during pregnancy, LCMV titers were ordered which demonstrated a positive IgG titer consistent with a remote LCMV infection.
Apr 20, 2021
Rim Kallala et.al. presented a reviewe of a 34-year healthy female patient who consulted for rehabilitation of the left first lower molar. The purpose of this paper was to detail the protocol of chairside system and provide a useful evaluation tool, through a clinical case carried out in the dental clinic of the Faculty of Dental Surgery Paul Sabatier Toulouse.
Apr 19, 2021
Mousavi Mirzaei S.M. et al. report a case of drug-induced aseptic meningitis in a 16-year-old male who presented with headache, fever, photophobia, nausea, vomiting and blurred vision. He gave a history of ibuprofen use a week back for muscle pain following exercise. Neck flexion restriction and bilateral papilledema were seen on examination and CSF demonstrated mononuclear pleocytosis and elevated protein. The antimicrobial therapy that he was started on was terminated as the infectious meningitis assessment turned negative.
Apr 19, 2021
Ryosuke Takada et.al. presented a case of a lateral foot pain of Hypertrophic peroneal tubercle coexisting with Os peroneum. Careful preoperative magnetic resonance imaging, dynamic ultrasonographic image, and block injection suggested an impingement of Hypertrophic peroneal tubercle and Os peroneum as a cause of lateral foot pain. This is the first report presenting a case of Hypertrophic peroneal tubercle coexisting with Os peroneum successfully treated without Os peroneum resection.