The USFDA has approved Fragmin, a low molecular weight heparin for the treatment of symptomatic venous thromboembolism and also to reduce recurrence VTE in pediatric patients of 1 months and older. The study showed that 21 patients achieved complete resolution, 7 patients showed regression, 2 patients showed no change.
News
May 22, 2019
According to study results published in The Journal of Clinical Endocrinology & Metabolism, Cardiorespiratory fitness does not place out of line the conncetion between obesity and inflammatory biomarkers in physically active women of older age. The results suggested that high-risk metabolic group showed elevated C-reactive protein levels, lower adiponectin levels, and higher inflammatory scores regardless of obesity.
May 22, 2019
According to results of the PUCCINI trial presented at Digestive Disease Week, TNF inhibitors in patients with Crohn’s disease and ulcerative colitis administrated preoperatively did not did not increase the risk for any postoperative infections or any postoperative surgical site infections. The study was aimed to find whether exposure to TNF inhibitors is an independent risk factor for postoperative infection in intra-abdominal surgery in Crohn’s disease and ulcerative colitis.
Journal Abstracts
May 21, 2019
A large number of studies studies have identified >240 loci that confer risk of IBD however inspite of this, the findings and mechanism remains unclear. Terrence S. Furey et.al. have summarized adult and paediatric patients who have identified with different sub types of IBD which have also been associated with distinct clinical phenotypes.
May 21, 2019
Geoffrey L. Heyer et.al. conducted a study to understand how patients with psychogenic nonsyncopal collapse (PNSC) perceive and communicate the prodromal symptoms associated with their attacks by comparing narratives between patients with PNSC and those with syncope. The researchers concluded that symptom narratives are of great help in distinguish patients with PNSC from those with real syncope.
May 21, 2019
Chest Pain is the most common presentation in all healthcare provider clinics. Thomas E. Kaier et.al. discuss and review the discovery and structure of cardiac myosin-binding protein, as well as the migration from a comparably insensitive to a high-sensitivity assay facilitating first clinical studies.
Recent Articles
May 22, 2019
Archives of Disease in Childhood (ADC) is an international and peer-reviewed journal specialising in child health, covering the perinatal period through to adolescence. As an official journal of the Royal College of Paediatrics and Child Health, ADC provides paediatricians with the most recent, relevant and original research reports, commentaries, clinical and policy reviews, and education.
May 22, 2019
Heart and Vessels is an English-language journal that provides a forum of original ideas, excellent methods, and fascinating techniques on cardiovascular disease fields. The current issue consists of articles on maintenance of atrial fibrillation, pharmacodynamics of prasugrel and clopidogrel etc.
May 22, 2019
BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
Clinical Research
May 21, 2019
The FIERCE-22 study is a Phase 1b/2 study to evaluate the effectiveness and safety of vofatamab (B-701) in combination with the immunotherapy drug pembrolizumab in the treatment of subjects with Stage IV, locally advanced or metastatic FGFR3 wild-type (WT) or mutation positive UCC who have previously been treated with a platinum-based chemotherapy for their bladder cancer which gotten worse or has come back or are not eligible for cisplatin-containing chemotherapy.
May 20, 2019
Maastricht University Medical Center is conducting an Interventional trial in about 65 participants in order to develop methods for reconstructing electrical heart activity non-invasively, and to use these methods to investigate cardiac rhythm disorders to answer clinical and scientific questions.
May 20, 2019
Centre Hospitalier Universitaire Dijon is conducting an Observational study in 2000 participants in order to improve the knowledge of the MEN1 mainly in describing its evolution over time globally and according to the initial presentation, genotype-phenotype correlations and heritability of the disease, real life management of patients and its impact on cure and survival for each type of MEN1-related tumor and impact on the patients' daily lives, their perception of the disease and their satisfaction with their care.
Publications
May 22, 2019
Archives of Disease in Childhood (ADC) is an international and peer-reviewed journal specialising in child health, covering the perinatal period through to adolescence. As an official journal of the Royal College of Paediatrics and Child Health, ADC provides paediatricians with the most recent, relevant and original research reports, commentaries, clinical and policy reviews, and education.
May 22, 2019
Heart and Vessels is an English-language journal that provides a forum of original ideas, excellent methods, and fascinating techniques on cardiovascular disease fields. The current issue consists of articles on maintenance of atrial fibrillation, pharmacodynamics of prasugrel and clopidogrel etc.
May 22, 2019
BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
Videos
May 19, 2019
Prof. Christian Gratzke elaborates what the significance of medical treatment today is and talks about the most promising developments in lower urinary tract symptoms (LUTS) which arise as a result of benign prostatic enlargement (BPE).
May 19, 2019
Stanford University's Victor G. Carrion, MD, discusses the neuroscience of pediatric trauma and the use of the cue-centered therapy approach for youth with post-traumatic symptoms. The cue-centered therapy is an evidence-based treatment program designed to treat children with repeated trauma exposure.
May 19, 2019
UCLA Neurosurgery at the David Geffen School of Medicine at UCLA presented its second annual comprehensive update on emerging diagnostic and treatment modalities for diseases of the brain and spine, drawing upon the department's world-class expertise in laser ablation for epilepsy.
May 19, 2019
Dr. Papazian Laurent from France talks about how ultrasound imaging helps in monitoring lung aeration, collapse and decollapse in patients in the intensive care units of hospitals and how to use it accurately to monitor the above.
Case Studies
Aug 05, 2019
This is a case of a 58 years old man with severe mucous membrane pemphigoid (MMP) who presented with onychomadesis. He presented with 2 years history of recurrent painful mouth sores and cutaneous blisters on his extremities and genital area. The patient was initially treated with 1 mg/kg of prednisone which resulted in rapid control of his symptoms but when the dose was tapered to 0.5 mg/kg the patient showed signs of disease recurrence. 2 g/kg/cycle of intravenous immunoglobulin therapy IVIG was added. The patient received three cycles on a monthly interval and showed remarkable improvement.
May 22, 2019
This is a case report of a spontaneously regressed myxofibrosarcoma successfully treated by resection where the extent of the tumor was determined from the initial MRI. This case demonstrates that myxofibrosarcoma has the potential to regress spontaneously, and an astute awareness of this phenomenon is necessary for appropriate management of this condition.
May 22, 2019
This is a case of a 27-year-old man presented with alveolar hemorrhage secondary to inhalation of synthetic cannabinoid. The patient developed hemoptysis and respiratory failure 48 hours after the inhalation. A urine and blood toxicology screen were negative for cannabinoid. Bronchoscopy was performed and showed oozing of blood from all right lung airways and the left lower lobe bronchus. The patient was empirically treated with high-dose steroid for 3 days, followed by prednisone 40 mg/day that was tapered to 10 mg/day over 4 days and then discontinued. Over the 48 hours after corticosteroid administration, his oxygenation improved significantly.
May 22, 2019
This is a case of a 68-year-old Thai woman diagnosed and treated for bullous pemphigoid (BP) for 11 months who recently presented with a 3-day history of extensive hemorrhagic bullae and large intra-oral buccal hematoma. Laboratory investigations confirmed a prolonged activated partial thromboplastin time, a low factor VIII level, a high factor VIII inhibitor level, and elevated anti-BPAG180 and anti-BPAG230 titers, confirming the diagnosis of BP associated with acquired hemophilia A (AHA). Immunosuppressive therapy with systemic corticosteroids and cyclophosphamide combined with bypassing agents for bleeding control resulted in significant clinical improvement and subsequent negative antibody levels.