The researchers at the university of Virginia School of Medicine have reported that medulloblastoma forms an intricate network to drive its growth. Some tumor cells actually turn into another cell type altogether. Such a discovery raises an exciting possibility that doctors might be able to intervene to fight several types of cancers.
News
Feb 14, 2020
Biochemical engineers from Columbia have designed a new probiotics strain that can seek out solid tumors and safely deliver immune checkpoint inhibitors after a single dose, resulting in tumor regression or both untreated and treated cancer lesions. The newly engineered probiotics safely deliver immunotherapies within tumors and include nanobodies against two proven therapeutic targets – PDL1 and CTLA4.
Feb 13, 2020
Victoria Furer et.al. conducted a systematic review of literature in order to update the European League Against Rheumatism (EULAR) recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. They concluded that Non-live vaccines can be safely provided to these patients, along with those Tetanus toxoid and human papilloma virus vaccination, Hepatitis A, hepatitis B and herpes zoster vaccination should be administered.
Journal Abstracts
Feb 17, 2020
Lindsay B. Kelmenson et.al. conducted a study to understand the pattern of elevation of rheumatoid factor as well as anti–citrullinated protein antibodies before the diagnosis of Rheumatoid Arthritis. The researches concluded that the different patterns of elevations in the antibody isotypes have implications in understanding the pathophysiology of development.
Feb 17, 2020
Pamela L. Lutsey et.al. conducted a study to find if Anticoagulant Therapy was associated with risk of fracture in the cases of. The researchers concluded that use of apixaban in comparison with warfarin was associated with lower fracture risk.
Feb 17, 2020
Death as a result of suffocation due to plastic bags is rare and most recorded deaths were of children or homicides. It requires a multi-disciplinary approach to understand and determine the cause of death in such cases. Paola Santoro et.al. conducted a review to understand the Forensic approach towards plastic bag suffocation with the help of review of literature and case reports.
Recent Articles
Feb 17, 2020
Pamela L. Lutsey et.al. conducted a study to find if Anticoagulant Therapy was associated with risk of fracture in the cases of. The researchers concluded that use of apixaban in comparison with warfarin was associated with lower fracture risk.
Feb 17, 2020
Death as a result of suffocation due to plastic bags is rare and most recorded deaths were of children or homicides. It requires a multi-disciplinary approach to understand and determine the cause of death in such cases. Paola Santoro et.al. conducted a review to understand the Forensic approach towards plastic bag suffocation with the help of review of literature and case reports.
Feb 14, 2020
It is a known fact that there is a window of opportunity for around 12-16 weeks for Rheumatoid Arthritis and it is during this phase that treatment gives optimum results. Peter C.Taylor et.al. conducted a review to assess opportunity with respect to heterogeneity of presentation, assessment, therapeutic goals and treatment options and lastly the importance of multidisciplinary approach in cases that require holistic care.
Clinical Research
Jan 31, 2020
This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective in arresting or remineralizing initial interproximal lesion in comparison to SDF applied without Super Floss or fluoride varnish applied alone.
Jan 31, 2020
This is the first study where BAY1163877 is given to humans. Impact of the study is to evaluate if patients with advanced solid cancers show advanced clinical benefit under the treatment with the pan FGFR inhibitor. Patients (all comers) will receive the study drug treatment in a dose-escalation scheme (no placebo group) to determine the safety, tolerability and maximum tolerated dose (MTD) of BAY1163877.
Jan 31, 2020
The present study will be a randomized trial investigating the impact of e-cigarette device type on reinforcement value and use among current smokers. Current smokers (n=100) will be randomly assigned to either a control group that does not receive an e-cigarette or one of two e-cigarette types: a customizable tank, or a pod.
Publications
Jan 29, 2020
This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomised trials, observational studies and epidemiology.
Jan 29, 2020
Promoting rational therapy within the discipline of cardiology, the American Journal of Cardiovascular Drugs covers all aspects of the treatment of cardiovascular disorders, particularly the place in therapy of newer and established agents. Via a program of reviews and original clinical research articles, the journal addresses major issues relating to treatment of these disorders, including the pharmacology, efficacy and adverse effects of the major classes of drugs; information on newly developed drugs and drug classes.
Jan 29, 2020
Journal of Diabetes Investigation is the core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes. The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. The Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology.
Videos
Jan 30, 2020
Dr. Patrick Kamath presented a talk on liver in cases of Cardiac diseases. The speaker has discussed in detail about its symptomatolgy, progression of symptoms, identification of diagnostic signs, recommended investigations and lastly current updates in the treatment strategies of the same.
Jan 30, 2020
Ashley E. Ross, MD, PhD, Executive Medical Director of the Mary Crowley Cancer Research Center in Dallas, discusses the current and potential impact of PSMA PET imaging on the identification and treatment of localized prostate cancer. He notes how PET PSMA and fluciclovine imaging can increase the accuracy of detecting clinically significant localized disease. Dr. Ross further discusses how PET imaging assists in risk stratification of candidates for treatment of HSPC, nmCRPC using salvage local therapy, metastasis-directed therapy, or intensification of systemic therapy. He also discusses how PET imaging can help identify candidates for cure with local treatments.
Jan 30, 2020
Ashley E. Ross, MD, PhD, Executive Medical Director of the Mary Crowley Cancer Research Center in Dallas, discusses the current and potential impact of PSMA PET imaging on the identification and treatment of localized prostate cancer. He notes how PET PSMA and fluciclovine imaging can increase the accuracy of detecting clinically significant localized disease. Dr. Ross further discusses how PET imaging assists in risk stratification of candidates for treatment of HSPC, nmCRPC using salvage local therapy, metastasis-directed therapy, or intensification of systemic therapy. He also discusses how PET imaging can help identify candidates for cure with local treatments.
Jan 30, 2020
Sasikumar Kilaikode et.al. presented a talk on Neuromuscular Disorders in children with a perspective of Pulmonology with an objective to discuss respiratory patholophysilogy of neuromuscular disease in children, outlining the monitoring of pulmonary features and discussing the management of chronic respiratory failure in children with neuro-muscular disorders in children.
Case Studies
Feb 12, 2020
The patient was suffering from leg tremor on standing for 2 years without any neurological signs. Since her orthostatic tremor with low-frequency discharge was responsive to dopaminergic medication, Fumihito Yoshii speculated that it might be a premotor sign of Parkinson’s disease. Her leg tremor symptoms completely disappeared post administration of levopoda 200 mg and pramipexole 0.75 mg.
Feb 11, 2020
A 45-year-old Woman of Pakistani decent came complaining of continual vomiting since the past 15-days. Sh was a known case of Diabetes, investigation findings were suggestive of Hypercalcemia. She was treated with intravenous fluids, intramuscular calcitonin 240 IU three times a day and oral furosemide 40 mg two times a day for hypercalcemia.
Feb 11, 2020
A 49-year-old female a known case of Anklyosing Spondylitis was admitted for surgery due to Aortic Insufficiency, histological findings revealed fibrosing endocarditis involving the aortic valve and there was also involvement of the Aortic root. Later on narrowing of the left main coronary artery was also observed.
Feb 11, 2020
A12-year-old female presented with a huge jaw swelling which was present since the past three months. The findings were clinically suggestive of Sarcoma. CT Scan showed a destructive mandibular mass and biopsy showed changes suggestive of cemento-ossifying fibroma thus leading to the diagnosis of Giant Mandibular Aneurysmal Bone Cyst With Cemento Ossifying Fibroma.