By Using sound vibrations and pulses of near-infrared light, a Rutgers University scientist has developed a new "virtual biopsy" device that can quickly determine a skin lesion's depth and potential malignancy without using a scalpel. The first-of-its-kind experimental procedure, called vibrational optical coherence tomography (VOCT), creates a 3-D map of the legion's width and depth under the skin with a tiny laser diode.
News
Jun 17, 2019
In a recent meta-analysis of 24 studies, Boone and a team of researchers considered 313 cases of borderline resectable pancreatic cancer that physicians treated with FOLFIRINOX. They analyzed the patients' overall survival rates. They also evaluated how frequently tumors shrank enough to be surgically removed. The team found that FOLFIRINOX prolonged patients' lives, on average, and made surgery possible in more instances.
Jun 17, 2019
A hair-sized probe that can measure key indicators of tissue damage deep in the lung has been developed by scientists. A team of scientists developed the probe, which comprises an optical fiber about 0.2mm in diameter that holds 19 sensors. Each sensor can measure different indicators in tissues, such as acidity and oxygen levels, which provide important information on the body's reaction to disease processes.
Journal Abstracts
Jun 14, 2019
The study aimed to assess the status of vitamin D for patients with pityriasis alba. 44 patient diagnosed with pityriasis alba were enrolled and the second group of 44 controls was involved in our study. Serum levels of circulating 25 (OH) D were measured. Study findings conclude none of the cases had sufficient serum level; the level ranged between 8.1-27.3 ng/ml. The patients had lower circulating vitamin D levels than controls.
Jun 14, 2019
This study is to determine the safety and preliminary efficacy of selective combination targeted therapy for BRAF V600E–mutant metastatic colorectal cancer (mCRC) in the safety lead-in phase of the open-label, randomized, three-arm, phase III BEACON Colorectal Cancer trial. In the safety lead-in, the safety and tolerability of the encorafenib, binimetinib, and cetuximab regimen are manageable and acceptable for initiation of the randomized portion of the study. The observed efficacy is promising compared with available therapies and, if confirmed in the randomized portion of the trial, could establish this regimen as a new standard of care for previously treated BRAF V600E–mutant mCRC.
Jun 14, 2019
This study examined whether individuals undergoing total hip arthroplasty who are self-rated as “highly active”, demonstrated higher pre-operative activity levels than others. The positive correlation between subjective and objective measures of mobility increase our confidence in the latter as a valid indicator of the patient's preoperative activity level.
Recent Articles
Jun 17, 2019
The results of a pilot study suggest that electrostimulation of one of the nerves connecting the brain to the body (the vagus nerve), could provide a novel treatment approach for patients with rheumatoid arthritis. In this study, a novel miniaturized neurostimulator called a MicroRegulator was implanted into 14 patients with rheumatoid arthritis who had failed on at least two biologics or targeted oral therapies with different mechanisms of action. Patients were randomized to three groups who were either placebo, stimulated once daily, or stimulated four times a day for 12 weeks. At the end of the study, the patients who received once-daily stimulation were shown to have a better response than those on four-times-daily stimulation.
Jun 17, 2019
The '4th National Conference on Prevention of Diabetes' is scheduled to be conducted between November 15-17, 2019 in Atlanta, Georgia. This conference will combine theory and practice, and will form a forum to disseminate new information, to learn from best practices and to have constructive debates around one of the most important public health issues, the prevention of diabetes and its complications (diabetic foot lesions in particular), and management of prediabetes with antidiabetic agents.
Jun 17, 2019
By Using sound vibrations and pulses of near-infrared light, a Rutgers University scientist has developed a new "virtual biopsy" device that can quickly determine a skin lesion's depth and potential malignancy without using a scalpel. The first-of-its-kind experimental procedure, called vibrational optical coherence tomography (VOCT), creates a 3-D map of the legion's width and depth under the skin with a tiny laser diode.
Clinical Research
Jun 17, 2019
Universidade Federal Fluminense is conducting an Observational study in 200 participants in order to propose cervicothoracic transcutaneous electrical nerve stimulation (TENS) as a non-pharmacological therapy to attenuate cardiac sympathetic overdrive in patients with heart failure.
Jun 17, 2019
Barts & The London NHS Trust is conducting an Observational study in 150 participants in order to identify new predisposition genes for endocrine tumours. The focus initially is on pituitary adenomas including growth hormone-secreting tumors (somatotrophinomas) and prolactin secreting tumours (prolactinomas), but the authors extended work to other pituitary tumour cases/families.
Jun 17, 2019
Alfasigma S.p.A. is conducting an Interventional study in 882 participants in order to evaluate the safety and efficacy of two different doses of a delayed release formulation of rifaximin, versus placebo, for the prevention of recurrence of acute diverticulitis and diverticular complications in patients with a recent episode of acute diverticulitis.
Publications
Jun 17, 2019
Annals of Surgical Oncology is one of the leading journals in Oncology and Surgery. Annals of Surgical Oncology is the official journal of the Society of Surgical Oncology. Annals benefits surgeons, oncologists, hematologists, radiologists, general practitioners, pathologists, researchers, academicians, and other clinical professionals interested in all aspects of the surgical treatment of cancer.
Jun 17, 2019
Current Dermatology Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of dermatological conditions.
Jun 17, 2019
This book covers all aspects of narrow band imaging (NBI), including research, general principles and diagnostic features in various ENT pathologies. In addition to highlighting the advantages of NBI over white light endoscopy for the detection of early cancers and lesions that are less than 1 cm in diameter, the book offers a step-by-step approach to help readers easily grasp various pathologies of the upper aerodigestive tract. It discusses both malignant and non-malignant aspects of NBI and provides extensive information on inflammatory lesions of the upper aerodigestive tract, including various clinical features of laryngopharyngeal reflux.
Videos
Jun 14, 2019
Watch UCLA gastroenterologist Dr. Lisa Lin, MD discuss the symptoms of acid reflux, how to test for it and the available treatment options.
Jun 14, 2019
Watch Dr. Itzhak Fried present "Laser Ablation for Epilepsy" at UCLA Neurosurgery Update 2019. UCLA Neurosurgery at the David Geffen School of Medicine at UCLA presented its second annual comprehensive update on emerging diagnostic and treatment modalities for diseases of the brain and spine, drawing upon the department's world-class expertise in each sub-specialty.
Jun 14, 2019
Watch Dr. Harvey Fishman, MD, Ph.D. discuss the role of intense pulsed light therapy to treat OSD. Eradicating Demodex helps keep the ocular microbiome healthy.
Jun 14, 2019
This webinar presents the infection risks associated with different vascular access types. Discussion includes strategies and recommendations for successful catheter reduction to prevent bloodstream infections. It includes a presentation on “Incident Vascular Access and Risk of Bloodstream Infection Among New ESRD Patients Receiving Hemodialysis” followed by a conversation about achieving optimal vascular access for patient safety.
Case Studies
Jun 17, 2019
A 44-year-old woman experienced transient numbness of her right sided face and arm and was referred to our unit due to small brain lesions in magnetic resonance imaging, with a possible diagnosis of multiple sclerosis. Neurological examination was unremarkable except for plantar reflexes and jerky deep tendon reflexes. Brain magnetic resonance angiography revealed findings typically seen in moyamoya disease, confirmed with digital subtraction angiography. Antiplatelet therapy started, but a few days later, she developed suddenly global aphasia and right hemiparesis (National Institutes of Health Stroke Scale/NIHSS 6). Brain magnetic resonance imaging revealed acute infarct in the distribution of the left middle cerebral artery. At her discharge, she was significantly improved (NIHSS 3).
Jun 17, 2019
Ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma is uncommon in the pediatric population. Initial misdiagnosis is common and there is lacking consensus regarding the optimal approach to treatment. Samantha Bobba et al report an atypical presentation of pediatric conjunctival MALT lymphoma and review the presentation and management of this rare condition.
Jun 17, 2019
The dyad of spontaneous pneumomediastinum and subcutaneous emphysema is collectively known as Hamman's syndrome. This rare complication is known to occur during the intrapartum period and its etiology has been linked to the Valsalva maneuver in the second stage of labor. Nitrous oxide inhalation increases the risk. Drishti Madhok et al present the case of a 21-year-old healthy woman who experienced these symptoms after nitrous oxide inhalation during the second stage of labor.
Jun 17, 2019
A 62-year-old white man was treated for a giant macroprolactinoma detected during an investigation of a subacute subdural hematoma of the left frontal lobe. The patient was treated with cabergoline for 17 years with a dose ranging from 1.0 mg to 3.5 mg per week. We were not able to normalize his prolactin level, which initially was 14,992 ng/ml and ultimately 1754 ng/ml. The tumor significantly shrank during the follow-up period but persisted. The patient had cardiac valvulopathies that did not worsen. He had an ischemic stroke and developed a psychotic condition that was successfully treated by lowering the cabergoline and administering quetiapine and mirtazapine together. This regimen led to a small increase in the patient’s prolactin that returned to previous levels and remained as such until the last medical evaluation. The tumor continued to shrink and had a cystic degeneration in the last evaluation.