News

Oct 27, 2020

NYU study is first to describe rates of physical, verbal, and reputational aggression by patients toward practicing dentists. Workplace violence toward health care professionals is both widespread and widely overlooked,” said Kimberly Rhoades, a research scientist in the Family Translational Research Group at NYU College of Dentistry and the study’s lead author. “The purpose of this study was to provide an initial estimate of rates of patient aggression in dental practices in the United States.”

Oct 27, 2020

A new research has found that less than 1% of U.S. dentists have tested positive for COVID-19, even though dental procedures generate aerosols that may contain particles of the new coronavirus. The researchers found that 99.7% of dentists said they had enacted enhanced infection control procedures at their offices - most commonly disinfection, COVID-19 screening, social distancing, and wearing face masks.

Oct 27, 2020

According to investigators presenting at the American Society of Nephrology’s Kidney Week 2020 Reimagined virtual conference, only a subset of patients with nondialysis-dependent chronic kidney disease (NDD-CKD) initiate anemia medication despite clinical signs indicating treatment. “These longitudinal data support the concept that anemia is suboptimally managed among patients with NDD-CKD in the real-world setting,” Dr Lopes said. “These data point to an opportunity for enhanced detection and improved management.”

Journal Abstracts

Oct 27, 2020

Lara G. Bakaeen et.al. conducted a study to  to examine dentists’ knowledge, attitudes and professional behavior towards COVID-19 and the impact on their livelihood through a multi-site survey. The researchers concluded that A new level of protective armamentarium in the dental operatory and updated operational guidance and policies are required, necessitating educators and regulators to ensure the delivery of knowledge and skills to oral healthcare providers. Dentists need to address the sustainability of their practices and have a robust business plan.

Oct 27, 2020

Jan Minners et.al conducted a study to determine the incidence and potential risk factors of sudden cardiac death (SCD) in asymptomatic aortic stenosis (AS) patients. The study demonstrates that SCD in asymptomatic AS patients is comparable to that in the general population which leads to the conclusion that the disease per se does not cause SCD instead SCD could be related to left ventricular hypertrophy.

Oct 26, 2020

Joseph Y. Abrams et.al did a review of eight studies on multisystem inflammatory syndrome in children (MIS-C) linked to COVID-19 infection. The studies were analysed with the objective to understand the syndrome and develop a universal case definition of MIS-C. The review of the studies shows that the majority of cases report elevated levels of C-reactive protein, interleukin-6, and fibrinogen. High prevalence of gastrointestinal, dermatologic/mucocutaneous, and cardiovascular symptoms was also noted among the patients with MIS-C.

Recent Articles

Oct 27, 2020

Research suggests around 36% of patients around the world have moderate dental anxiety. Approximately 12% of patients have cancelled their dental appointment due to the feeling of nervousness. As per the author, a new way of conversing, such as simplifying into Lehman’s terms and using various imagery, has a calming effect on some patients. Showing them visual aids or short videos on the treatment is useful. Allowing time to discuss this with your patients also helps.

Oct 27, 2020

A new research has found that less than 1% of U.S. dentists have tested positive for COVID-19, even though dental procedures generate aerosols that may contain particles of the new coronavirus. The researchers found that 99.7% of dentists said they had enacted enhanced infection control procedures at their offices - most commonly disinfection, COVID-19 screening, social distancing, and wearing face masks.

Oct 27, 2020

Milton Packer, M.D et.al. carried out a double-blind trial involving 3730 patients with class II, III, or IV heart failure to check the efficacy of Empagliflozin. The patients received the drug or a placebo in addition to recommended therapy. It could be concluded from the results of the trial that the patients on empagliflozin had a lower risk of cardiovascular death or hospitalization due to heart failure as compared to those on placebo.

Clinical Research

Oct 21, 2020

A placebo-controlled, randomised cross-over study on 28 patients with frontotemporal dementia was conducted with the objective to determine the effect of oxytocin on those regions of the brain associated with empathy and emotional processing. The patients were given intranasal oxytocin or placebo who then completed an fMRI facial expression mimicry task. The study concluded that oxytocin alone and in combination with instructed mimicry results in enhanced neural activity in these regions and also points to their latent capacity. to augment neural activity.

Jun 19, 2020

The purpose of this Phase 1, multicenter, open-label study was to determine the maximum tolerated dose (MTD) of AG-636 and characterize its dose-limiting toxicities (DLTs) when given by mouth to subjects with advanced lymphoma that is refractory to standard treatment. During the dose-escalation part of the study successive cohorts of subjects will be treated with increasing doses of AG-636 in order to determine its maximum tolerated dose (MTD). Subsequently, in the dose-expansion part of the study, additional subjects will be treated at the MTD in order to confirm that dose's safety, tolerability, PK and PD, and to provide an opportunity to detect anti-lymphoma activity. The dose expansion part of the study will support the selection of a dose for future clinical studies (a recommended Phase 2 dose [RP2D]).

Jun 01, 2020

The purpose of this study is to find the most effective dose of radiation therapy to give to breast tumors in a shorter period of time, prior to standard partial mastectomy/axillary surgery.

Jun 01, 2020

The purpose of this study is to find the most effective dose of radiation therapy to give to breast tumors in a shorter period of time, prior to standard partial mastectomy/axillary surgery.

Jun 01, 2020

This research study is being done to understand how patients with chronic cancer pain take their long-acting opioid medications and to develop an intervention to enhance cancer pain management.

Feb 27, 2020

Christopher G. Brennan-Jones et.al. identified specific strategies which have shown effectiveness in reducing workplace noise. These include implementation of stricter legislation and also stress upon the need for training in the proper use of earplugs and earmuffs so as to reduce noise exposure to safe levels. 

Feb 27, 2020

Daniel G. Whitney et.al. conducted a study to determine prevalence of major noncommunicable diseases in young adults with pediatric-onset disabilities and compared it in adults without pediatric onset disabilities. The researchers found that young adults with pediatric onset disabilities showed an early onset of several noncommunicable diseases. They were contributors to global and national burden of disease and mortality.

Publications

Jun 26, 2020

In patients with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), a once-daily oral regimen of ibrutinib and venetoclax was associated with deep molecular remissions in both bone marrow and peripheral blood, including in patients with high-risk disease, according to investigators in phase 2 CAPTIVATE MRD trial.

Jun 04, 2020

Georgios Tsakonas et.al. conducted a study to understand the alterations in gene expression in brain metastasis versus primary tumour as it may increase aggressiveness and impair therapeutic efforts. The researchers concluded  identified a unique gene downregulation pattern in brain metastases compared with primary tumours. This finding may explain the lower intracranial efficacy of systemic therapy, especially immunotherapy, in brain metastasis of patients with non–small-cell lung cancer. 

Jun 01, 2020

Advance in Cancer Prevention addresses all types of cancer, how cancer forms in the body, and their prevention. It focuses on Cancer Vaccines, Chemotherapy, Radioactive Iodine Therapy, Breast Reconstruction Surgery, Mammography, Chemoprevention, aromatase inhibitors, Scintimammography, Oncoplastic surgery, Sumoylation, Dietary Supplements, Cancer Screening, Cancer and Nutrition, Exercise and Cancer, Alternative Cancer Medicines, Stem cell transplants for cancer prevention, Naturopathic Treatments, Clinical Naturopathy, Cancer Prevention from nuts.

Jan 29, 2020

This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomised trials, observational studies and epidemiology.

Jan 29, 2020

Promoting rational therapy within the discipline of cardiology, the American Journal of Cardiovascular Drugs covers all aspects of the treatment of cardiovascular disorders, particularly the place in therapy of newer and established agents. Via a program of reviews and original clinical research articles, the journal addresses major issues relating to treatment of these disorders, including the pharmacology, efficacy and adverse effects of the major classes of drugs; information on newly developed drugs and drug classes. 

Jan 29, 2020

Journal of Diabetes Investigation is the core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes. The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. The Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology.

Jan 29, 2020

Hepatobiliary Surgery and Nutrition focuses on new findings in hepatopancreatobiliary disease and nutrition, and to provide current and practical information on diagnosis, prevention and clinical investigations. Specific areas of interest include, but not limited to, surgical techniques, clinical and basic researches, transplantation and other therapies, NASH, NAFLD, targeted drug, gut microbiota, metabolism, cancer immunity, genomics, nutrition and dietetics, etc.

Videos

Oct 21, 2020

A 30-year-old female presented with rapid onset of acute dysarthria and left oculomotor paralysis. The MRI showed ruptured anterior midbrain cavernoma. A conservative approach was adopted as the patient was stable. However, one month later she experienced a new bleed with right hemiparesis, diplopia and severe dysarthria. The haemorrhage extended to the surface of the midbrain anteriorly and extended posteriorly without reaching the surface of the safe entry zone. The approach to a cavernous malformation via safe zones are not always feasible due to the proximity of several critical neural structures as in this case. The resection via a posterolateral route using the supracerebellar infratentorial approach was performed successfully.

Oct 21, 2020

A 30-year-old female presented with rapid onset of acute dysarthria and left oculomotor paralysis. The MRI showed ruptured anterior midbrain cavernoma. A conservative approach was adopted as the patient was stable. However, one month later she experienced a new bleed with right hemiparesis, diplopia and severe dysarthria. The haemorrhage extended to the surface of the midbrain anteriorly and extended posteriorly without reaching the surface of the safe entry zone. The approach to a cavernous malformation via safe zones are not always feasible due to the proximity of several critical neural structures as in this case. The resection via a posterolateral route using the supracerebellar infratentorial approach was performed successfully.

Jul 17, 2020

As many as half of patients diagnosed with metastatic HER2-positive breast cancer will see their cancer spread to their brain. Though brain metastases, or "Brain Mets," are rare, they are exceedingly difficult to treat, so these patients experience poor outcomes. At this year’s ASCO meeting, Dr. Nancy Lin of Dana-Farber Cancer Institute presented promising results from the HER2CLIMB trial for these patients. In this video BCRF talks with Dr. Lin about her research focus, Brain Mets, and HER2CLIMB’s findings.

 

Jul 10, 2020

Watch Dr. Jamie Studts discuss the quality implementation of lung cancer screening and share his thoughts on optimizing community-based implementation.
 

Case Studies

Oct 27, 2020

Neelam Mittal et.al. presented a case of a 32-year-old female who reported with a chief complaint of pain in the upper left back tooth, which she reported was increasing while biting and taking cold or hot beverages. This case report describes endodontic management of a case with such aberrant root canal morphology of a maxillary second molar having a single root and single canal.

Oct 27, 2020

Terry Zhu et.al. presented a case of a 2-month-old full-term female who presented with a large anterior sacral meningomyelocele resulting in transient obstructive uropathy with bilateral hydronephrosis and acute kidney injury. After initial bladder decompression and surgical resection of the meningomyelocele, there was spontaneous resolution of bladder function confirmed with urodynamics.

Oct 27, 2020

Hussein Al-Mohamad et.al. presented the case of a 43-year-old female with a past medical history of Marfan Syndrome (MFS), who consulted her cardiologist after being diagnosed with an abdominal aortic dissection which showed up in an abdominal CT. The patient had no complaints of pain and was hemodynamically stable. Physical examination revealed several features typical to MFS. The patient underwent successful surgical repair of her abdominal aortic dissection via a minimally invasive open retroperitoneal approach.

Oct 26, 2020

The case presented by Tharmini Danisious et.al. is that of a 12-year-old girl with low grade fever of one-month duration associated with a non-productive cough whose abdominal examination revealed a firm mass on the left hypochondriac region. Subsequently,  a solitary mass confined to the left kidney with para aortic lymphadenopathy causing left ureteric compression and hydronephrosis was detected in ultrasound abdomen. Excisional biopsy of perihilar lymph node and a tru-cut biopsy from the renal mass performed showed features compatible with sinus histiocytosis with massive lymphadenopathy. The case reports a rare presentation of Rosai-Dorfman disease.