Any impairment in the functioning of the placenta in pregnant women could potentially lead to future metabolic disorders in children and adults, according to a study. The study could find an association between the placental IGF-1 receptor protein and serum triglycerides in children that could cause obesity or diabetes later. Other proteins in the placenta were also linked with increased fat tissue on the arms and thighs of children. Researchers hope that with this knowledge, treatment modalities that aim at decreasing the risk to the fetus could be devised.
News
Jan 27, 2021
A clinical trial found, Children who are deaf or hard of hearing can learn to express themselves with longer phrases, take more turns in conversations, and develop more words in their vocabulary when they receive assistive speech technology. Researchers randomly assigned 41 children aged 3 to 12 years with mild to profound bilateral hearing loss to receive usual care for speech and language therapy on its own, or augmented with a technology-assisted language intervention.
Jan 27, 2021
A new type of artificial cornea, KPro, that integrates directly into the eyewall has been developed and successfully implanted. The artificial cornea has a clear middle section that serves as the cornea and a skirt surrounding the clear section made of a material that allows infiltration by fibroblasts and collagen. The procedure for implantation involves the removal of the epithelium covering the cornea followed by the removal of old cornea and then suturing the new artificial one in place.
Journal Abstracts
Jan 27, 2021
Pablo Padilla-Iserte et al. conducted a retrospective multicentric study to assess the oncological outcomes after minimally invasive surgery with the use of uterine manipulator in subjects with early-stage endometrial cancer. The study included 2661 women of which 1756 patients underwent hysterectomy with a uterine manipulator and 905 without it. A recurrence rate of 11.69% in the uterine manipulator group and 7.4% in the no-manipulator group along with lower disease-free survival and a higher risk of death in the former group was observed. The results of the study point to a worse oncological outcome associated with the use of a uterine manipulator in patients.
Jan 27, 2021
Reza Ghaffari et al. conducted a retrospective case series analysis aimed at reporting complications associated with cosmetic artificial iris implantation and explantation outcomes. The medical records of 12 patients who underwent implantation of cosmetic artificial irises were evaluated for presenting symptoms, examination findings, and management outcomes. The subjects presented with varying symptoms such as iris abnormalities, elevated intraocular pressure, corneal edema, intraocular inflammation, and cataract. It was seen that even after surgical intervention serious long term complications (which included among others native iris defects, persistent glaucoma and cataract) persisted.
Jan 27, 2021
Elinzano, Heinrich et.al. conducted a study to determine the maximum tolerated dose and preliminary efficacy of pegylated nanoliposomal irinotecan metronomic temozolomide in patients with recurrent glioblastoma. The researchers concluded that the maximum tolerated dose of nal-IRI was 50 mg/m2 every 2 weeks with metronomic temozolomide 50 mg/m2/d. The dose-limiting toxicities were diarrhea and neutropenia. No activity was seen at interim analysis and the study was terminated.
Recent Articles
Jan 27, 2021
A new type of artificial cornea, KPro, that integrates directly into the eyewall has been developed and successfully implanted. The artificial cornea has a clear middle section that serves as the cornea and a skirt surrounding the clear section made of a material that allows infiltration by fibroblasts and collagen. The procedure for implantation involves the removal of the epithelium covering the cornea followed by the removal of old cornea and then suturing the new artificial one in place.
Jan 27, 2021
John F. Payne et al. conducted a multicentre, randomised clinical trial to determine the long-term effects of treat-and-extend dosing of ranibizumab with and without navigated focal laser for diabetic macular oedema. The study involving 150 eyes found that after 2 years of treat-and-extend ranibizumab, improvements in best-corrected visual acuity and central retina thickness could be achieved and these improvements could be maintained in the third year with a mean of 3 intravitreal injections.
Jan 27, 2021
According to a small study that suggests snoring might contribute to cardiovascular risk in these individuals, young to middle-aged adults who are overweight or obese, and heavy snorers have an increased risk for vascular remodeling even when they don't have obstructive sleep apnea. Researchers examined data on 122 adults with overweight or obesity who were assessed using the snoring index, which measures snoring vibration, and the oxygen desaturation index, which determines the presence and severity of obstructive sleep apnea.
Clinical Research
Jun 01, 2020
The purpose of this study is to find the most effective dose of radiation therapy to give to breast tumors in a shorter period of time, prior to standard partial mastectomy/axillary surgery.
Jun 01, 2020
This research study is being done to understand how patients with chronic cancer pain take their long-acting opioid medications and to develop an intervention to enhance cancer pain management.
Feb 27, 2020
Christopher G. Brennan-Jones et.al. identified specific strategies which have shown effectiveness in reducing workplace noise. These include implementation of stricter legislation and also stress upon the need for training in the proper use of earplugs and earmuffs so as to reduce noise exposure to safe levels.
Publications
Jun 26, 2020
In patients with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), a once-daily oral regimen of ibrutinib and venetoclax was associated with deep molecular remissions in both bone marrow and peripheral blood, including in patients with high-risk disease, according to investigators in phase 2 CAPTIVATE MRD trial.
Jun 04, 2020
Georgios Tsakonas et.al. conducted a study to understand the alterations in gene expression in brain metastasis versus primary tumour as it may increase aggressiveness and impair therapeutic efforts. The researchers concluded identified a unique gene downregulation pattern in brain metastases compared with primary tumours. This finding may explain the lower intracranial efficacy of systemic therapy, especially immunotherapy, in brain metastasis of patients with non–small-cell lung cancer.
Jun 01, 2020
Advance in Cancer Prevention addresses all types of cancer, how cancer forms in the body, and their prevention. It focuses on Cancer Vaccines, Chemotherapy, Radioactive Iodine Therapy, Breast Reconstruction Surgery, Mammography, Chemoprevention, aromatase inhibitors, Scintimammography, Oncoplastic surgery, Sumoylation, Dietary Supplements, Cancer Screening, Cancer and Nutrition, Exercise and Cancer, Alternative Cancer Medicines, Stem cell transplants for cancer prevention, Naturopathic Treatments, Clinical Naturopathy, Cancer Prevention from nuts.
Videos
Oct 21, 2020
A 30-year-old female presented with rapid onset of acute dysarthria and left oculomotor paralysis. The MRI showed ruptured anterior midbrain cavernoma. A conservative approach was adopted as the patient was stable. However, one month later she experienced a new bleed with right hemiparesis, diplopia and severe dysarthria. The haemorrhage extended to the surface of the midbrain anteriorly and extended posteriorly without reaching the surface of the safe entry zone. The approach to a cavernous malformation via safe zones are not always feasible due to the proximity of several critical neural structures as in this case. The resection via a posterolateral route using the supracerebellar infratentorial approach was performed successfully.
Oct 21, 2020
A 30-year-old female presented with rapid onset of acute dysarthria and left oculomotor paralysis. The MRI showed ruptured anterior midbrain cavernoma. A conservative approach was adopted as the patient was stable. However, one month later she experienced a new bleed with right hemiparesis, diplopia and severe dysarthria. The haemorrhage extended to the surface of the midbrain anteriorly and extended posteriorly without reaching the surface of the safe entry zone. The approach to a cavernous malformation via safe zones are not always feasible due to the proximity of several critical neural structures as in this case. The resection via a posterolateral route using the supracerebellar infratentorial approach was performed successfully.
Jul 17, 2020
As many as half of patients diagnosed with metastatic HER2-positive breast cancer will see their cancer spread to their brain. Though brain metastases, or "Brain Mets," are rare, they are exceedingly difficult to treat, so these patients experience poor outcomes. At this year’s ASCO meeting, Dr. Nancy Lin of Dana-Farber Cancer Institute presented promising results from the HER2CLIMB trial for these patients. In this video BCRF talks with Dr. Lin about her research focus, Brain Mets, and HER2CLIMB’s findings.
Jul 10, 2020
Watch Dr. Jamie Studts discuss the quality implementation of lung cancer screening and share his thoughts on optimizing community-based implementation.
Case Studies
Jan 27, 2021
Ilias Galanis et al. report a case of a rare aggressive tumor, large cell neuroendocrine carcinoma (LCNC), in an 80-year-old woman with a history of several comorbidities who presented with abdominal pain and distension. A palpable mass in the right inguinal area was observed on physical examination and a CT scan of the abdomen revealed it to be a big cystic tumor from the right ovary. The patient underwent a right salpingooophorectomy and histopathology showed a mixed ovarian neoplasm having a cystic and a solid component with the characteristics of a high-grade LCNC.
Jan 27, 2021
Wiebke Wesemüller et.al. presented a case of a case of spontaneous Tumor lysis syndrome in a male patient who was referred with unspecific symptoms and suspected metastatic malignancy.The case emphasizes the life-saving relevance of early detection and appropriate treatment of Tumor lysis syndrome. It also demonstrates the importance of actively screening for Tumor lysis syndrome, primarily in patients with malignant diseases and high tumor load, even if they are not receiving cytotoxic therapy.
Jan 27, 2021
Tomotaka Hemmi et.al. presented a case of a lingual osseous choristoma, in an elderly patient, that was incidentally removed by coughing and cured without additional interventions. No signs of recurrence were found during the 15-month follow-up examination. This case serves as a reminder of this rare entity in the diagnosis of tongue masses of the elderly.
Jan 27, 2021
Kono S. et al. report the case of a 47-year-old woman who presented with persistent foreign body sensation in the right eye. A pinkish-yellow linear soft tissue lesion centrally along the lower conjunctival fornix was observed on examination. Orbital computed tomographic images revealed a purely conjunctival mass and she underwent excisional biopsy. Subsequent histopathological findings were seen to be consistent with amyloidosis.