News

Jan 15, 2021

According to a randomized trial that included more than 160 patients, patients with knee osteoarthritis who wear stable supportive shoes for 6 months have greater average reductions in knee pain when walking, compared with patients who wear flat flexible shoes. Abnormal knee joint loading has been implicated in the pathogenesis of knee OA. Guidelines recommend that patients wear appropriate footwear, but research has not established which shoes are best.

Jan 15, 2021

Results of a published study suggest that patients with shoulder impingement syndrome who underwent arthroscopic subacromial decompression had no clinically relevant improvements at 5-year follow-up compared with diagnostic arthroscopy or exercise therapy. Researchers randomly assigned 210 patients 35 to 65 years of age who had symptoms consistent with shoulder impingement syndrome for more than 3 months to undergo either exercise therapy or surgery.

Jan 15, 2021

Ilene Tisnovsky et.al. conducted a study to propose a gunshot wound-related hip injury algorithm and improve patient outcomes. The researchers concluded that various therapeutic strategies have been used for the management of gunshot wound-related hip injuries but further prospective studies are necessary to determine the optimal therapeutic modality.

Journal Abstracts

Jan 15, 2021

The meta-analysis carried out by Suetonia C Palmer et al. aimed to determine the effect of sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists in patients with type 2 diabetes. The study included an analysis of 764 randomised control trials and found that both classes of drugs lowered all cause mortality, cardiovascular mortality, non-fatal myocardial infarction, and kidney failure. SGLT-2 inhibitors were found to reduce mortality and hospital admission for heart failure whereas GLP-1 receptor agonists reduced non-fatal stroke.

Jan 14, 2021

Miguel Guia et.al. conducted a study to identify relevant citations using the search terms (with synonyms and closely related words) “non-invasive ventilation”, “tracheostomy” and “weaning”. The researchers found that review supports a potential role for non-invasive ventilation in weaning patients with a tracheostomy either off the ventilator and/or with its decannulation. Additional research is needed to develop weaning protocols and better characterize the role of non-invasive ventilation during weaning.

Jan 14, 2021

Riccardo Cappato et al. carried out a study that sought to analyse the effect of DOAC dose selection on the risk of all-cause mortality in patients with established atherosclerosis. Literature research for trials that involved a random assignment to a lower dose DOAC, a higher dose DOAC, or control therapy to such patients was done. It was seen that patients receiving a lower dose had a significant reduction of all-cause mortality.

Recent Articles

Jan 15, 2021

Ilene Tisnovsky et.al. conducted a study to propose a gunshot wound-related hip injury algorithm and improve patient outcomes. The researchers concluded that various therapeutic strategies have been used for the management of gunshot wound-related hip injuries but further prospective studies are necessary to determine the optimal therapeutic modality.

Jan 15, 2021

Pauline Besonhe et.al. presented a case of a newborn in which surgery was necessary to free both fingers and toes from constrictive bands responsible for ischemia. In the absence of surgery, the constrictive bands can lead to amputation (pseudoainhum). The purpose of this case report is to expose the management and the role of an orthopaedic surgeon in the treatment of a collodion baby.

Jan 15, 2021

T2DM patients who have been on metformin therapy is found to benefit from the drug in that metformin is associated with a threefold decrease in mortality due to COVID-19. The exact mechanism behind this beneficial effect is unknown but it could be attributed to the anti-inflammatory and anti-thrombotic effects of the drug. A mortality rate of 11 percent was observed among metformin users as opposed to the 23 percent among nonusers, pointing to the possibility of a protective effect the drug might impart to diabetic patients.

Clinical Research

Jun 01, 2020

The purpose of this study is to find the most effective dose of radiation therapy to give to breast tumors in a shorter period of time, prior to standard partial mastectomy/axillary surgery.

Jun 01, 2020

This research study is being done to understand how patients with chronic cancer pain take their long-acting opioid medications and to develop an intervention to enhance cancer pain management.

Feb 27, 2020

Christopher G. Brennan-Jones et.al. identified specific strategies which have shown effectiveness in reducing workplace noise. These include implementation of stricter legislation and also stress upon the need for training in the proper use of earplugs and earmuffs so as to reduce noise exposure to safe levels. 

Feb 27, 2020

Christopher G. Brennan-Jones et.al. identified specific strategies which have shown effectiveness in reducing workplace noise. These include implementation of stricter legislation and also stress upon the need for training in the proper use of earplugs and earmuffs so as to reduce noise exposure to safe levels. 

Feb 27, 2020

Daniel G. Whitney et.al. conducted a study to determine prevalence of major noncommunicable diseases in young adults with pediatric-onset disabilities and compared it in adults without pediatric onset disabilities. The researchers found that young adults with pediatric onset disabilities showed an early onset of several noncommunicable diseases. They were contributors to global and national burden of disease and mortality.

Jan 31, 2020

This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective in arresting or remineralizing initial interproximal lesion in comparison to SDF applied without Super Floss or fluoride varnish applied alone.

Jan 31, 2020

This is the first study where BAY1163877 is given to humans. Impact of the study is to evaluate if patients with advanced solid cancers show advanced clinical benefit under the treatment with the pan FGFR inhibitor. Patients (all comers) will receive the study drug treatment in a dose-escalation scheme (no placebo group) to determine the safety, tolerability and maximum tolerated dose (MTD) of BAY1163877.

Publications

Jan 12, 2021

Recent evidence that SARS-CoV-2 vaccine is associated with inflammatory reactions in patients with dermal fillers has led the American Society for Dermatologic Surgery to issue a guidance outlining the potential risk and clinical relevance. Of a total of 15,184 participants who received at least one dose of mRNA-1273, three developed facial or lip swelling that was presumably related to dermal filler. In the placebo group, there were no comparable inflammatory events.

Jun 26, 2020

In patients with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), a once-daily oral regimen of ibrutinib and venetoclax was associated with deep molecular remissions in both bone marrow and peripheral blood, including in patients with high-risk disease, according to investigators in phase 2 CAPTIVATE MRD trial.

Jun 04, 2020

Georgios Tsakonas et.al. conducted a study to understand the alterations in gene expression in brain metastasis versus primary tumour as it may increase aggressiveness and impair therapeutic efforts. The researchers concluded  identified a unique gene downregulation pattern in brain metastases compared with primary tumours. This finding may explain the lower intracranial efficacy of systemic therapy, especially immunotherapy, in brain metastasis of patients with non–small-cell lung cancer. 

Jun 01, 2020

Advance in Cancer Prevention addresses all types of cancer, how cancer forms in the body, and their prevention. It focuses on Cancer Vaccines, Chemotherapy, Radioactive Iodine Therapy, Breast Reconstruction Surgery, Mammography, Chemoprevention, aromatase inhibitors, Scintimammography, Oncoplastic surgery, Sumoylation, Dietary Supplements, Cancer Screening, Cancer and Nutrition, Exercise and Cancer, Alternative Cancer Medicines, Stem cell transplants for cancer prevention, Naturopathic Treatments, Clinical Naturopathy, Cancer Prevention from nuts.

Jan 29, 2020

This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomised trials, observational studies and epidemiology.

Jan 29, 2020

Promoting rational therapy within the discipline of cardiology, the American Journal of Cardiovascular Drugs covers all aspects of the treatment of cardiovascular disorders, particularly the place in therapy of newer and established agents. Via a program of reviews and original clinical research articles, the journal addresses major issues relating to treatment of these disorders, including the pharmacology, efficacy and adverse effects of the major classes of drugs; information on newly developed drugs and drug classes. 

Jan 29, 2020

Journal of Diabetes Investigation is the core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes. The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. The Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology.

Videos

Oct 21, 2020

A 30-year-old female presented with rapid onset of acute dysarthria and left oculomotor paralysis. The MRI showed ruptured anterior midbrain cavernoma. A conservative approach was adopted as the patient was stable. However, one month later she experienced a new bleed with right hemiparesis, diplopia and severe dysarthria. The haemorrhage extended to the surface of the midbrain anteriorly and extended posteriorly without reaching the surface of the safe entry zone. The approach to a cavernous malformation via safe zones are not always feasible due to the proximity of several critical neural structures as in this case. The resection via a posterolateral route using the supracerebellar infratentorial approach was performed successfully.

Oct 21, 2020

A 30-year-old female presented with rapid onset of acute dysarthria and left oculomotor paralysis. The MRI showed ruptured anterior midbrain cavernoma. A conservative approach was adopted as the patient was stable. However, one month later she experienced a new bleed with right hemiparesis, diplopia and severe dysarthria. The haemorrhage extended to the surface of the midbrain anteriorly and extended posteriorly without reaching the surface of the safe entry zone. The approach to a cavernous malformation via safe zones are not always feasible due to the proximity of several critical neural structures as in this case. The resection via a posterolateral route using the supracerebellar infratentorial approach was performed successfully.

Jul 17, 2020

As many as half of patients diagnosed with metastatic HER2-positive breast cancer will see their cancer spread to their brain. Though brain metastases, or "Brain Mets," are rare, they are exceedingly difficult to treat, so these patients experience poor outcomes. At this year’s ASCO meeting, Dr. Nancy Lin of Dana-Farber Cancer Institute presented promising results from the HER2CLIMB trial for these patients. In this video BCRF talks with Dr. Lin about her research focus, Brain Mets, and HER2CLIMB’s findings.

 

Jul 10, 2020

Watch Dr. Jamie Studts discuss the quality implementation of lung cancer screening and share his thoughts on optimizing community-based implementation.
 

Case Studies

Jan 15, 2021

Pauline Besonhe et.al. presented a case of a newborn in which surgery was necessary to free both fingers and toes from constrictive bands responsible for ischemia. In the absence of surgery, the constrictive bands can lead to amputation (pseudoainhum). The purpose of this case report is to expose the management and the role of an orthopaedic surgeon in the treatment of a collodion baby.

Jan 15, 2021

Morika Suzuki et al. report the case of a 55-year-old man who presented with fever and dysuria. Subsequent to his hospital admission he showed urinary retention and later on developed involuntary movements of the extremities, nuchal rigidity, hyperreflexia of the deep tendon reflexes, and pathological reflexes in the bilateral lower extremities. Lumbar puncture revealed elevated cerebrospinal pressure, protein count and cell count with dominant mononuclear cells. Based on the findings a diagnosis of urinary retention due to meningitis-retention syndrome (MRS) with aseptic meningitis was made. A positive polymerase chain reaction test for Epstein–Barr virus led to the identification of EBV reactivation as the cause of MRS.

Jan 14, 2021

Teruhito Takakuwa et al. report the case of a 75‐year‐old male who developed high‐grade B‐cell lymphoma following treatment with tyrosine kinase inhibitors for CML. The patient was diagnosed with CML and was treated with imatinib which was changed to nilotinib and subsequently to bosutinib. Twenty five years later he presented with posterior neck pain and malaise and he was diagnosed with a stage III HGBCL based on findings from CT and lymph node biopsies. Bosutinib was discontinued and he was administered EPOCH‐R which led to complete remission.

Jan 14, 2021

Michael Agustin et.al. presented a case of a case of spontaneous left-side chylothorax following septic pulmonary embolization with Methicillin-Resistant Staphylococcus aureus. This is a rare case of a nonmalignant, nontraumatic, and nontuberculous spontaneous chylothorax which was conservatively treated with fibrinolysis and diet modification.