News

Jan 24, 2020

According to the BCBS Association, The Blue Cross Blue Shield Association and 18 independent and locally-operated BCBS companies are partnering with Civica Rx to lower the cost of generic prescription drugs and the 18 BCBS companies will provide $55 million to help create a Civica subsidiary. The effort will focus on generics that currently carry a high price tag as a result of limited or no competition.

Jan 23, 2020

Scientists have discovered that a non-invasive technique that could one day be used to treat Parkinson’s disease, can successfully target a highly specific group of brain cells that play a key role in the development of the condition. In 2015, scientists demonstrated that a form of gene therapy could target and stimulate a group of nerve cells affected by the disease, called cholinergic neurons. These cells degenerate as the disease progresses. Now, thanks to brain imaging technology, they have discovered that their method, which targets cells that produce specific brain chemicals, can also successfully stimulate another type of neuron through cell-to-cell interactions.  

Jan 23, 2020

In patients with neovascular age-related macular disease, a treat-and-extend ranibizumab regimen is not inferior to injections given at fixed intervals, plus it's more convenient, according to a new clinical trial. The goal in treating macular degeneration, the most common cause of blindness in the western world, is to maximize visual gains and minimize the burden of treatment and visits on patients and their families. 

Journal Abstracts

Jan 22, 2020

Considering that areflexia or hyporeflexia is a necessary clinical criterion for Guillain-Barré syndrome (GBS) diagnosis, researchers conducted this systematic review to analyze hyper-reflexia in GBS. According to results, 73.3% of individuals were from Japan, 6.7% from the USA, 6.7% from India, 4.4% from Italy, 4.4% from Turkey, 2.2% from Switzerland and 2.2% from Slovenia, implying a considerable geographical variation. Hyper-reflexia was linked to antecedent diarrhea more often than upper respiratory tract infection and the electrodiagnosis of acute motor axonal neuropathy than acute inflammatory demyelinating polyneuropathy. Electrophysiological studies displayed high soleus maximal H-reflex amplitude to maximal compound muscle action potential amplitude ratio, indicative of spinal motoneuron hyperexcitability, and increased central conduction time, indicative of corticospinal tract involvement, though structural damage was never shown by MRI. Hyperreflexia does not contradict the GBS diagnosis and should not postpone treatment. Hyper-reflexia can occur in all GBS variants and subtypes, and this eventuality should be mentioned in future GBS diagnostic criteria.

Jan 22, 2020

Considering that areflexia or hyporeflexia is a necessary clinical criterion for Guillain-Barré syndrome (GBS) diagnosis, researchers conducted this systematic review to analyze hyper-reflexia in GBS. According to results, 73.3% of individuals were from Japan, 6.7% from the USA, 6.7% from India, 4.4% from Italy, 4.4% from Turkey, 2.2% from Switzerland and 2.2% from Slovenia, implying a considerable geographical variation. Hyper-reflexia was linked to antecedent diarrhea more often than upper respiratory tract infection and the electrodiagnosis of acute motor axonal neuropathy than acute inflammatory demyelinating polyneuropathy. Electrophysiological studies displayed high soleus maximal H-reflex amplitude to maximal compound muscle action potential amplitude ratio, indicative of spinal motoneuron hyperexcitability, and increased central conduction time, indicative of corticospinal tract involvement, though structural damage was never shown by MRI. Hyperreflexia does not contradict the GBS diagnosis and should not postpone treatment. Hyper-reflexia can occur in all GBS variants and subtypes, and this eventuality should be mentioned in future GBS diagnostic criteria.

Jan 22, 2020

Jyh Haur Woo et al assessed the outcomes and complications of hybrid Descemet membrane endothelial keratoplasty (H-DMEK) utilizing a Descemet stripping automated endothelial keratoplasty (DSAEK) pull-through donor inserter and donor stroma as a carrier. The sample consisted of eyes with bullous keratopathy (BK) and Fuchs endothelial corneal dystrophy (FECD), which had H-DMEK, performed using a bimanual pull-through technique using DSAEK-prepared donor stroma as carrier and the EndoGlide Ultrathin DSAEK donor insertion device. Of the 85 eyes from 79 individuals, 43.5% (n = 37) had BK, 28.2% (n = 24) had FECD while 24.7% (n = 21) had failed grafts. According to results, hybrid DMEK provides a controlled ‘pull-through’ technique of donor insertion in the ‘endothelium-in’ configuration, which can be helpful particularly in complicated eyes. In order to confirm the long-term endothelial cell loss and graft survival related to this technique, more studies are required.

Recent Articles

Jan 24, 2020

Deep vein thrombosis after femoral arterial access is a rare complication of left heart catheterization. This case highlights the complex pathophysiology of Deep vein thrombosis following femoral arterial access and the challenges of management strategy selection.

Jan 24, 2020

This is a case of a 30-year-old female presenting with fatigue, abdominal striae, unintentional weight gain, and lipodystrophy. A rare diagnosis of ectopic adrenocorticotropic-dependent CS was determined and a neuroendocrine lung tumor was discovered on chest x-ray. After surgical resection, pathology confirmed lung neuroendocrine lung tumor that stained positive for adrenocorticotropic hormone.

Jan 24, 2020

This is a case of a 30-year-old female presenting with fatigue, abdominal striae, unintentional weight gain, and lipodystrophy. A rare diagnosis of ectopic adrenocorticotropic-dependent CS was determined and a neuroendocrine lung tumor was discovered on chest x-ray. After surgical resection, pathology confirmed lung neuroendocrine lung tumor that stained positive for adrenocorticotropic hormone.

Clinical Research

Jan 23, 2020

This is a study to evaluate the pharmacokinetics (PK), safety and tolerability of ABBV-157 in healthy volunteers and in participants with chronic plaque psoriasis, and to evaluate the efficacy of ABBV-157 in the participants with psoriasis. This study consists of two substudies. Substudy 1 is a randomized, double-blind, placebo-controlled evaluation of multiple ascending oral doses of ABBV-157 in healthy adult volunteers. Substudy 2 is a randomized, double-blind, placebo-controlled study in which participants with moderate to severe chronic plaque psoriasis will be administered multiple oral doses of ABBV-157.

Jan 23, 2020

This study aims to understand how to manipulate the electrical stimulation from the cochlear implant to maximize hearing stimulation and minimize facial stimulation. It is known from animal data that the hearing and facial nerves have different sensitivities to things like electrical pulse shape, its pattern, and its duration. It is very unclear however if this applies to human cochlear implant patients, and what the optimal parameters are to selectively stimulate the hearing nerve in humans. The outcomes of this study will be used to more selectively program some patients with severe facial nerve cross stimulation and to inform the development of new types of implant stimulation.

Jan 23, 2020

This is a prospective, single-arm, multi-center, post-approval study designed to evaluate the short and long term clinical performance and safety in subjects receiving primary total knee arthroplasty (TKA) with the U2 Knee™ System. The study will enroll up to 200 subjects with scheduled pre-discharge, 6-week, 3- and 6-month and up to 5-year annual follow-up visits. Study outcomes will be analyzed and published when 1.) all enrolled and implanted subjects complete their 6-week follow up, 2.) all implanted subjects complete their 2-year follow up, 3.) at the conclusion of the study.

Jan 23, 2020

This is a prospective, single-arm, multi-center, post-approval study designed to evaluate the short and long term clinical performance and safety in subjects receiving primary total knee arthroplasty (TKA) with the U2 Knee™ System. The study will enroll up to 200 subjects with scheduled pre-discharge, 6-week, 3- and 6-month and up to 5-year annual follow-up visits. Study outcomes will be analyzed and published when 1.) all enrolled and implanted subjects complete their 6-week follow up, 2.) all implanted subjects complete their 2-year follow up, 3.) at the conclusion of the study.

Jan 23, 2020

This is a randomized controlled, 2-arm, parallel-group substudy of the TB-SEQUEL cohort study. It will enroll drug-sensitive TB patients with the moderately advanced or far advanced pulmonary disease by chest X-ray. Patients providing informed consent will undergo screening evaluations to establish eligibility. Patients meeting all the inclusion and none of the exclusion criteria will be randomized to receive standard TB treatment (2HRZE/4HR) plus NAC 1200 mg BID for months 1-4 or standard treatment alone. During the treatment period, patients will undergo safety, efficacy, and biomarker assessments at specified time points. After a final evaluation at 6 months, patients will continue follow-up as a part of the main TB-SEQUEL cohort study.

Jan 23, 2020

 

A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at ~ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.

Jan 23, 2020

This study proposes to use standard methods of clinical testing for endocrine and nonendocrine diseases and genetic testing in order to; 1. Define the genetic basis for PPNAD and/or the Carney Complex. 2. Determine the molecular changes associated with the development of the tumors. 3. Identify carriers of the disease. 4. Determine the prognosis for carriers and affected individuals. 5. Provide sufficient data for genetic counseling of families with PPNAD and/or Carney Complex.

Publications

Jan 23, 2020

This book reviews the principles of infection control and the guidelines and standards of care in multiple countries, discussing them within the context of the practice of dentistry. The aim is to enable dental practitioners to ensure that the appropriate measures are adopted for each patient contact, thereby minimizing the risk of transmission of infection – a goal that is becoming ever more important given the threats posed by new or re-emerging infectious diseases and drug-resistant infections.

Jan 23, 2020

From the basic science underpinnings to the most recent developments in medical and surgical care, Campbell-Walsh-Wein Urology offers a depth and breadth of coverage you won't find in any other urology reference. Now in three manageable volumes, the revised 12th Edition is a must-have text for students, residents, and seasoned practitioners, with authoritative, up-to-date content in an intuitively organized, easy-to-read format featuring key points, quick-reference tables, and handy algorithms throughout.

Jan 23, 2020

This book highlights the importance of investigating for ADHD in adults with attention difficulties, poor memory and executive function impairments. The authors advocate a neurodevelopmental assessment approach in all phases of life, and explain how to perform such assessments. The identification of ADHD in adults with other psychiatric and neurological disorders will lead to a better response to treatments, and as a result reduce its social, economic and personal burden.

Jan 23, 2020

This work provides a one-of- a-kind volume that includes all aspects of heart transplantation from its historic beginning to its current day standards which now make the procedure a long-term treatment option for heart failure patients.  The subjects covered include technical aspects of the procurement and implant procedures, as well as the medical nuances of pre-operative preparation and post-transplant immunosuppression management; etc.

Jan 23, 2020

This book provides a comprehensive overview of highly infectious diseases (HIDs) in the ICU. The text is designed to help critical care specialists and other healthcare practitioners prepare and plan for potential outbreaks of emerging or resurgent HIDs, lead a team in the ICU, perform emergency triage, and provide care for patients with a HID. The book also reviews some of the most prevalent highly infectious diseases, including influenza, SARS, plague, anthrax, and malaria.

Jan 22, 2020

Molecular Imaging and Biology presents original research contributions on the utilization of molecular imaging in problems of relevance in biology and medicine. The primary objective of the journal is to provide a forum for the discovery of molecular mechanisms of health and disease through the use of imaging techniques.

Jan 22, 2020

Pediatric Pulmonology is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood.  Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins.

Videos

Jan 23, 2020

Dr. McClain's interactive talk focused on explaining the management of ascites, including the role of TIPS, describing how to recognize and treat PSE, and discussing the importance of not over-transfusing a patient with bleeding esophageal varices.

Jan 23, 2020

Scott McEwen presented a talk on Pediatric Hypertension with an objective of understanding the increasing prevalence and modifiable risk factors for pediatric hypertension, and its impact on adult cardiovascular disease. Understanding the difference between primary and secondary hypertension, and when extensive evaluation for the cause of hypertension is indicated and lastly understanding how improved identification of hypertension improves treatment and outcomes, and introduced the project at the University of Minnesota to improve blood pressure measurement in clinic.

Jan 23, 2020

Scott McEwen presented a talk on Pediatric Hypertension with an objective of understanding the increasing prevalence and modifiable risk factors for pediatric hypertension, and its impact on adult cardiovascular disease. Understanding the difference between primary and secondary hypertension, and when extensive evaluation for the cause of hypertension is indicated and lastly understanding how improved identification of hypertension improves treatment and outcomes, and introduced the project at the University of Minnesota to improve blood pressure measurement in clinic.

Jan 23, 2020

Sunil Rao presented a talk about improving the safety of PCI with respect to discussing updates on diagnosis, treatment and management of cardiovascular disease, integrating data and available technique in order to reach appropriate treatment decisions. and lastly describing research models, methods and statistical tools.

Case Studies

Jan 24, 2020

A 13-year-old boy with giant accessory spleen underwent spontaneous intrasplenic hemorrhage who presented with recurrent abdominal pain. Contrast-enhanced MRI was mandatory for the diagnosis before surgical procedure.

Jan 24, 2020

A 13-year-old boy with giant accessory spleen underwent spontaneous intrasplenic hemorrhage who presented with recurrent abdominal pain. Contrast-enhanced MRI was mandatory for the diagnosis before surgical procedure.

Jan 24, 2020

Deep vein thrombosis after femoral arterial access is a rare complication of left heart catheterization. This case highlights the complex pathophysiology of Deep vein thrombosis following femoral arterial access and the challenges of management strategy selection.

Jan 24, 2020

This is a case of a 30-year-old female presenting with fatigue, abdominal striae, unintentional weight gain, and lipodystrophy. A rare diagnosis of ectopic adrenocorticotropic-dependent CS was determined and a neuroendocrine lung tumor was discovered on chest x-ray. After surgical resection, pathology confirmed lung neuroendocrine lung tumor that stained positive for adrenocorticotropic hormone.