News

Sep 13, 2019

There has been a sudden increase in the number of Americans without health insurance for the first time in 10 years. The data suggests that  8.5%of the population didn't have health insurance at any point during 2018 which translates to 27.5 million people approximately and this is 2 million people more from 2017. These findings have come at a time when the fate of the ACA is in the hands of a federal appeals court

Sep 12, 2019

A new study suggests that mergency department openings and closures had an impact on bystander emergency departments especially for heart attack patients. The results of the study suggest that hospital closure can impact care quality at a neighboring hospital by placing stress on the healthcare infrastructure. Hospital closures represent a not-often reported social determinant of health, as they stress patient resources, the researchers added. 

Sep 11, 2019

The American Academy of Neurology and the American Headache Society has now updated two guidelines in the treatment as well as prevention of acute migraines in children as well as adolescents. Incorporation of more recently approved triptan nasal sprays, and certain triptan-nonsteroidal anti-inflammatory drug combinations can be added. The guidelines do not indicate all triptans but the ones the researchers studied. 

Journal Abstracts

Sep 13, 2019

The objective of this study was to determine the prevalence of wheezes and crackles in a large general adult population and explore associations with self-reported disease, smoking status, and lung function. Age was the most important predictor of adventitious sounds, particularly crackles. The adventitious sounds were also associated with the self-reported disease, current smoking, and measures of lung function. The presence of findings in two or more auscultation sites was associated with a higher risk of decreased lung function than solitary findings.

Sep 13, 2019

This study is to determine how current temporomandibular joint (TMJ) reconstruction methods affect functional outcomes. All patients who underwent mandibulectomy with subsequent reconstruction with vascularized free tissue were included in the study. Reconstruction of the TMJ with vascularized free tissue is a viable option and yields acceptable long-term outcomes. While functional status may improve or worsen in the immediate postoperative period, long term results mirror preoperative function. Preoperative trismus will likely improve.

Sep 13, 2019

This study is to examine the distribution of stage at diagnosis for 12 cancers in Kuwait, to estimate stage-specific net survival at 1 and 5 years after diagnosis, and to assess differences in stage-specific survival between Kuwait and the United States.  Since stage-specific survival is similar in Kuwait and the US, late-stage at diagnosis is likely to be a major contributing factor to the overall lower survival in Kuwait than in the US. Increasing public awareness of cancer risk factors and symptoms and investment in early detection will be vital to reduce the proportion of patients diagnosed at a late stage and to improve survival.

Recent Articles

Sep 13, 2019

This study is to compare the overall and subgroup incidence of long-term opioid use in a population of opioid-naive patients with hidradenitis suppurativa (HS) and control patients. In this cohort study of 22 277 patients with hidradenitis suppurativa, the overall crude 1-year incidence of long-term opioid use was twice (0.33%) than among control patients (0.14%). The risk of long-term opioid use was 53% greater among patients with hidradenitis suppurativa after controlling for relevant confounders.

Sep 13, 2019

This study is to determine how current temporomandibular joint (TMJ) reconstruction methods affect functional outcomes. All patients who underwent mandibulectomy with subsequent reconstruction with vascularized free tissue were included in the study. Reconstruction of the TMJ with vascularized free tissue is a viable option and yields acceptable long-term outcomes. While functional status may improve or worsen in the immediate postoperative period, long term results mirror preoperative function. Preoperative trismus will likely improve.

Sep 13, 2019

This study is to examine the distribution of stage at diagnosis for 12 cancers in Kuwait, to estimate stage-specific net survival at 1 and 5 years after diagnosis, and to assess differences in stage-specific survival between Kuwait and the United States.  Since stage-specific survival is similar in Kuwait and the US, late-stage at diagnosis is likely to be a major contributing factor to the overall lower survival in Kuwait than in the US. Increasing public awareness of cancer risk factors and symptoms and investment in early detection will be vital to reduce the proportion of patients diagnosed at a late stage and to improve survival.

Clinical Research

Sep 12, 2019

This study is to determine the effect of twice-daily chlorhexidine oral rinse on oral and lung microbiota biomass in subjects with chronic obstructive pulmonary disease (COPD) with chronic bronchitis. The primary outcome will be to compare the microbiota biomass (number of bacteria as measured by 16S rRNA copy number) of induced sputum and the oral cavity before and after 8 weeks of twice-daily chlorhexidine oral rinse (n=25) compared to controls (n=25) using qPCR and next-generation sequencing of the bacterial 16S rRNA gene comparing total bacterial biomass.

Sep 12, 2019

The study team will selectively grow the subject's protective Staph colonies and place them into a moisturizer. The first part of the study will determine the half-life of the bacteria-containing moisturizer. The bacteria-containing moisturizer will be applied to a subject's arm, and the subject will return at four different time points over the next three days for skin swabs of the arm that will be used to determine the amount and type of bacteria on the arm at those time points. In the second part of the study, the subject will apply a moisturizer containing his own antimicrobial bacteria to one of his arms for a total of 6 times at a frequency determined by the half-life, which will be computed at the end of the first part of this experiment.

Sep 12, 2019

SPI-1005 is a novel oral drug that contains a glutathione peroxidase mimetic (ebselen) that will be tested in subjects with a history of NIHL at risk for additional NIHL. The goal of this multi-center Phase 2b study is to determine whether SPI-1005 is effective in reducing an acute NIHL in this affected population. In this Phase, 2b study subjects with prior NIHL will be enrolled and exposed to a calibrated sound challenge (CSC) that induces a slight acute NIHL.

 

Sep 12, 2019

SPI-1005 is a novel oral drug that contains a glutathione peroxidase mimetic (ebselen) that will be tested in subjects with a history of NIHL at risk for additional NIHL. The goal of this multi-center Phase 2b study is to determine whether SPI-1005 is effective in reducing an acute NIHL in this affected population. In this Phase, 2b study subjects with prior NIHL will be enrolled and exposed to a calibrated sound challenge (CSC) that induces a slight acute NIHL.

 

Sep 12, 2019

This phase I/II trial studies the side effects and best dose of lenalidomide when given together with combination chemotherapy and to see how well they work in treating patients with v-myc myelocytomatosis viral oncogene homolog (avian) (MYC)-associated B-cell lymphomas.

Sep 11, 2019

This is a multicenter, randomized, double-blind, placebo-controlled trial to assess the safety and nutritional benefits of Metanx® in subjects with diabetic peripheral neuropathy. The objectives of the MEDIAN study are to evaluate the short-term and long-term safety and nutritional benefits of Metanx® versus placebo in subjects with mild to moderate diabetic peripheral neuropathy (DPN). Short-term effects will be evaluated during the first 16 weeks of treatment, and long-term effects will be evaluated over the duration of a 48 week treatment period.

Sep 11, 2019

The purpose of this study is to investigate the effect of benralizumab on the rate of asthma exacerbations, patient-reported quality of life and lung function during the 24-week treatment in patients with uncontrolled, severe asthma with an eosinophilic phenotype. A subset of patients will be assessed for their ongoing chronic rhinosinusitis with nasal polyps.

Publications

Sep 11, 2019

Pediatric Dermatology answers the need for new ideas and strategies for today's pediatrician or dermatologist. As a teaching vehicle, the Journal is still unsurpassed and it will continue to present the latest on topics such as hemangiomas, atopic dermatitis, rare and unusual presentations of childhood diseases, neonatal medicine, and therapeutic advances.

Sep 11, 2019

Pediatric Dermatology answers the need for new ideas and strategies for today's pediatrician or dermatologist. As a teaching vehicle, the Journal is still unsurpassed and it will continue to present the latest on topics such as hemangiomas, atopic dermatitis, rare and unusual presentations of childhood diseases, neonatal medicine, and therapeutic advances.

Sep 11, 2019

Trends in Cardiovascular Medicine provides in depth state-of-the-art reviews of scientific advances in cardiovascular medicine, written and critiqued by internationally known experts. Articles present an authoritative understanding on a range of topics, including basic mechanisms, diagnosis, treatment, and prognosis of heart and blood vessel disorders for clinicians and basic scientists.

Sep 11, 2019

'Endocrine Practice' is the journal of the The American Association of Clinical Endocrinologists. It is a professional community of physicians specializing in endocrinology, diabetes, and metabolism. They are committed to enhancing members’ knowledge, education, and practice management skills so they can focus on providing the highest quality of patient care. They also advocate for the profession to create understanding of the value of community to patients, organizations and the public.

Sep 11, 2019

The Hepatitis B Annual is published by the Kalinga Gastroenterology Foundation, a public charity. This Peer-reviewed Journal is published Annual, as a medium for articles related to different aspects of Hepatitis B viral infection including epidemiology, prevention and disease control, and management of the infection and its sequelae. 

Sep 11, 2019

Medical Physics is a journal of global scope and reach.Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments. 

Sep 09, 2019

Gastric Cancer, a joint official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, publishes significant studies related to stomach neoplasms. The journal welcomes original articles, case reports, short communications, and technical notes, which will be peer-reviewed by the editorial board. Letters to the Editor commenting on articles published in the journal or expressing views on topics concerning gastric cancer are also welcomed. Review articles are in principle solicited by the Editor.

Videos

Sep 13, 2019

 

Craniocervical junction dural arteriovenous fistulas (dAVFs) are rare vascular lesions with a potentially dangerous natural history due to the onset of neurological deficit secondary to intracranial hemorrhage or myelopathy due to venous congestion. Despite advances in endovascular techniques, many dAVFs located in this area continue to require surgical treatment as embolization is often not feasible or safe. In this video, the authors illustrate a patient with a symptomatic craniocervical junction dAVF who had undergone attempted Onyx embolization at another institution. Because of persistent filling of the fistula and worsening myelopathy after the previous attempt, the patient was referred to the authors’ clinic for definitive surgical treatment. The video illustrates the typical location of the early draining vein in most craniocervical junction dAVFs immediately below the emergence of the vertebral artery from the dura. The patient underwent successful definitive clip ligation of the fistula, which was exposed through a lateral suboccipital craniotomy.

Sep 13, 2019

Watch Dr. Timothy Snow, DO & Jin Yoo, MD from the Duke Center for Metabolic and Weight Loss Surgery present a patient who has undergone a laparoscopic sleeve gastrectomy. They discuss numerous technical pearls regarding abdominal access, trocar placement, pain management, and operative steps with an explanation of anatomy and pitfalls.

Sep 13, 2019

 

Robotic left ovary removal due to recurrent endometriosis. This surgery is performed with 3 laparoscopic port leaving 3 small incisions on the abdomen. The instrument used: DaVinci robotic hysterectomy

Sep 12, 2019

Sylvia Owusu-Ansah is a board-certified pediatrician, pediatric emergency medicine, and emergency medical services (EMS) physician. In this podcast she has discussed about emergency medicine in the field of pediatrics. She has stressed upon the need for more people to be trained in this field and has discussed various scenarios where the state of emergency medicine could be improved. 

Case Studies

Sep 13, 2019

A 11-year-old boy presented with progressive epigastric pain, and no oral intake since 2 weeks. The patient was in post transplant state due to end stage renal failure and was on immunotherapy. Endoscopy showed patchy redness and thickened gastric folds including exudate involving the gastric antrum and the first part of the duodenum. Prussian blue staining revealed iron deposits and the patient was diagnosed with iron pill-induced gastritis. 

Sep 13, 2019

Deep vein thrombosis after femoral arterial access is a rare complication of left heart catheterization. This is a compilation of two cases where one case is of provoked DVT after femoral access followed by a second case in which clot formation appears to be spontaneous.  

Sep 13, 2019

 A 71-year-old man with longstanding, previously well-controlled type 1 diabetes who developed acute hyperglycemia. His insulin requirements, via his insulin pump, increased to nearly five times his typical daily dose. The patient was admitted for evaluation and treatment and started on an insulin infusion. History revealed recent use of a super potent topical corticosteroid for a psoriasis flare. He was advised to discontinue using his topical corticosteroid. He had no further hyperglycemic episodes.

Sep 13, 2019

This a case of repetitive intentional foreign body ingestion (950 paperclips, 50 screws, eight batteries, and seven razor blades covered in paper) which demonstrates psychiatric complexity as well as diagnostic and treatment challenges associated with this self-injurious behavior.