The USFDA has approved Fragmin, a low molecular weight heparin for the treatment of symptomatic venous thromboembolism and also to reduce recurrence VTE in pediatric patients of 1 months and older. The study showed that 21 patients achieved complete resolution, 7 patients showed regression, 2 patients showed no change.
Geoffrey L. Heyer et.al. conducted a study to understand how patients with psychogenic nonsyncopal collapse (PNSC) perceive and communicate the prodromal symptoms associated with their attacks by comparing narratives between patients with PNSC and those with syncope. The researchers concluded that symptom narratives are of great help in distinguish patients with PNSC from those with real syncope.
According to a recent report at National Lipid Association Scientific Sessions, Genetic testing can be used for diagnosis of conditions like familial hypercholesterolemia in Lipid Clinics. Among the listed possibilities of genetic testing include changing management, family planning, patient preference, eligibility for new drugs etc.
According to study results published in The Journal of Clinical Endocrinology & Metabolism, Cardiorespiratory fitness does not place out of line the conncetion between obesity and inflammatory biomarkers in physically active women of older age. The results suggested that high-risk metabolic group showed elevated C-reactive protein levels, lower adiponectin levels, and higher inflammatory scores regardless of obesity.
According to results of the PUCCINI trial presented at Digestive Disease Week, TNF inhibitors in patients with Crohn’s disease and ulcerative colitis administrated preoperatively did not did not increase the risk for any postoperative infections or any postoperative surgical site infections. The study was aimed to find whether exposure to TNF inhibitors is an independent risk factor for postoperative infection in intra-abdominal surgery in Crohn’s disease and ulcerative colitis.
The FIERCE-22 study is a Phase 1b/2 study to evaluate the effectiveness and safety of vofatamab (B-701) in combination with the immunotherapy drug pembrolizumab in the treatment of subjects with Stage IV, locally advanced or metastatic FGFR3 wild-type (WT) or mutation positive UCC who have previously been treated with a platinum-based chemotherapy for their bladder cancer which gotten worse or has come back or are not eligible for cisplatin-containing chemotherapy.
The University of Texas Health Science Center, Houston is conducting an Observational study in about 100 participants in order to assess the coagulation system in-vitro in a variety of bleeding and clotting disorders using the ROTEG analyzer and the thrombin generation assay.
Maastricht University Medical Center is conducting an Interventional trial in about 65 participants in order to develop methods for reconstructing electrical heart activity non-invasively, and to use these methods to investigate cardiac rhythm disorders to answer clinical and scientific questions.
Archives of Disease in Childhood (ADC) is an international and peer-reviewed journal specialising in child health, covering the perinatal period through to adolescence. As an official journal of the Royal College of Paediatrics and Child Health, ADC provides paediatricians with the most recent, relevant and original research reports, commentaries, clinical and policy reviews, and education.
Heart and Vessels is an English-language journal that provides a forum of original ideas, excellent methods, and fascinating techniques on cardiovascular disease fields. The current issue consists of articles on maintenance of atrial fibrillation, pharmacodynamics of prasugrel and clopidogrel etc.
BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
Prof Graham Ogg speaks about the research his specialty covers. Topics covered include the impact skin conditions can have on patients' lives; taking blood samples from patients with skin diseases to further understand their conditions and clinical trials of new drugs for eczema, psoriasis and skin cancer.
The NIHR Medtech and In vitro diagnostics Co-operatives have supported Mologic Ltd, a UK-based SME, in its development of a urine-based test for an early indication of exacerbation of COPD, simple enough for patients to monitor their disease status at home, enabling care in the community reducing A&E visits and admissions.
In this video, Tomas G. Neilan discusses the importance of detecting and preventing heart injury in patients receiving chemotherapy. He and his team recently published findings on diagnosing and treating myocarditis related to immune therapies. He believes that this new knowledge can advance oncology care for patients suffering from the adverse effects of chemotherapy.
Dr. Papazian Laurent from France talks about how ultrasound imaging helps in monitoring lung aeration, collapse and decollapse in patients in the intensive care units of hospitals and how to use it accurately to monitor the above.
This is a case of a 58 years old man with severe mucous membrane pemphigoid (MMP) who presented with onychomadesis. He presented with 2 years history of recurrent painful mouth sores and cutaneous blisters on his extremities and genital area. The patient was initially treated with 1 mg/kg of prednisone which resulted in rapid control of his symptoms but when the dose was tapered to 0.5 mg/kg the patient showed signs of disease recurrence. 2 g/kg/cycle of intravenous immunoglobulin therapy IVIG was added. The patient received three cycles on a monthly interval and showed remarkable improvement.
This is a case of a 68-year-old Thai woman diagnosed and treated for bullous pemphigoid (BP) for 11 months who recently presented with a 3-day history of extensive hemorrhagic bullae and large intra-oral buccal hematoma. Laboratory investigations confirmed a prolonged activated partial thromboplastin time, a low factor VIII level, a high factor VIII inhibitor level, and elevated anti-BPAG180 and anti-BPAG230 titers, confirming the diagnosis of BP associated with acquired hemophilia A (AHA). Immunosuppressive therapy with systemic corticosteroids and cyclophosphamide combined with bypassing agents for bleeding control resulted in significant clinical improvement and subsequent negative antibody levels.
This is a case of a 67-year-old woman, sigmoid colon cancer was incidentally detected on preoperative upper gastrointestinal endoscopy. Endoscopy revealed a slightly elevated lesion at the minor duodenal papilla. The findings of a histopathologic examination were suggestive of adenocarcinoma. Computed tomography and magnetic resonance images identified a minute tumor, whereas endoscopic ultrasonography revealed that the tumor did not spread to the pancreas. Doctors performed endoscopic mucosal resection (EMR) of this lesion. There were no complications, and relapse has not occurred in 3 years.
This is a case report of a spontaneously regressed myxofibrosarcoma successfully treated by resection where the extent of the tumor was determined from the initial MRI. This case demonstrates that myxofibrosarcoma has the potential to regress spontaneously, and an astute awareness of this phenomenon is necessary for appropriate management of this condition.