News

May 22, 2019

The USFDA has approved Fragmin, a low molecular weight heparin for the treatment of symptomatic venous thromboembolism and also to reduce recurrence VTE in pediatric patients of 1 months and older. The study showed that  21 patients achieved complete resolution, 7 patients showed regression, 2 patients showed no change. 

May 22, 2019

According to study results published in The Journal of Clinical Endocrinology & Metabolism, Cardiorespiratory fitness does not place out of line the conncetion between obesity and inflammatory biomarkers in physically active women of older age. The results suggested that high-risk metabolic group showed elevated C-reactive protein levels, lower adiponectin levels, and higher inflammatory scores regardless of obesity. 

May 22, 2019

According to results of the PUCCINI trial presented at Digestive Disease Week, TNF inhibitors in patients with Crohn’s disease and ulcerative colitis administrated preoperatively did not did not increase the risk for any postoperative infections or any postoperative surgical site infections. The study was aimed to find whether exposure to TNF inhibitors is an independent risk factor for postoperative infection in intra-abdominal surgery in Crohn’s disease and ulcerative colitis. 

Journal Abstracts

May 21, 2019

Chest Pain is the most common presentation in all healthcare provider clinics. Thomas E. Kaier et.al. discuss and review the discovery and structure of cardiac myosin-binding protein, as well as the migration from a comparably insensitive to a high-sensitivity assay facilitating first clinical studies. 

May 21, 2019

A large number of studies studies have identified >240 loci that confer risk of IBD however inspite of this, the findings and mechanism remains unclear. Terrence S. Furey et.al. have summarized adult and paediatric patients who have identified with different sub types of IBD which have also been associated with distinct clinical phenotypes. 

May 21, 2019

Seyed Mohammad Seyedsaadat et.al. assessed the safety and feasibility of remote ischemic preconditioning in patients with an unruptured intracranial aneurysm who undergo elective endovascular treatment. The researchers concluded that remote ischemic preconditioning before endovascular intracranial aneurysm repair was well tolerated  safe and clinically feasible.  

Recent Articles

May 22, 2019

Journal of Radiotherapy in Practice is a peer-reviewed journal covering all of the current modalities specific to clinical oncology and radiotherapy. The journal aims to publish research from a wide range of styles and encourage debate and the exchange of information and opinion from within the field of radiotherapy practice and clinical oncology. The journal also aims to encourage technical evaluations and case studies as well as equipment reviews that will be of interest to an international radiotherapy audience.

May 22, 2019

Prof Graham Ogg speaks about the research his specialty covers. Topics covered include the impact skin conditions can have on patients' lives; taking blood samples from patients with skin diseases to further understand their conditions and clinical trials of new drugs for eczema, psoriasis and skin cancer.

May 22, 2019

This is a case of a  68-year-old Thai woman diagnosed and treated for bullous pemphigoid (BP) for 11 months who recently presented with a 3-day history of extensive hemorrhagic bullae and large intra-oral buccal hematoma. Laboratory investigations confirmed a prolonged activated partial thromboplastin time, a low factor VIII level, a high factor VIII inhibitor level, and elevated anti-BPAG180 and anti-BPAG230 titers, confirming the diagnosis of BP associated with acquired hemophilia A (AHA). Immunosuppressive therapy with systemic corticosteroids and cyclophosphamide combined with bypassing agents for bleeding control resulted in significant clinical improvement and subsequent negative antibody levels. 

 

Clinical Research

May 21, 2019

The FIERCE-22 study is a Phase 1b/2 study to evaluate the effectiveness and safety of vofatamab (B-701) in combination with the immunotherapy drug pembrolizumab in the treatment of subjects with Stage IV, locally advanced or metastatic FGFR3 wild-type (WT) or mutation positive UCC who have previously been treated with a platinum-based chemotherapy for their bladder cancer which gotten worse or has come back or are not eligible for cisplatin-containing chemotherapy. 

May 20, 2019

The University of Texas Health Science Center, Houston is conducting an Observational study in about 100 participants in order to assess the coagulation system in-vitro in a variety of bleeding and clotting disorders using the ROTEG analyzer and the thrombin generation assay.

May 20, 2019

Maastricht University Medical Center is conducting an Interventional trial in about 65 participants in order to develop methods for reconstructing electrical heart activity non-invasively, and to use these methods to investigate cardiac rhythm disorders to answer clinical and scientific questions.

May 20, 2019

Maastricht University Medical Center is conducting an Interventional trial in about 65 participants in order to develop methods for reconstructing electrical heart activity non-invasively, and to use these methods to investigate cardiac rhythm disorders to answer clinical and scientific questions.

May 20, 2019

Centre Hospitalier Universitaire Dijon is conducting an Observational study in 2000 participants in order to improve the knowledge of the MEN1 mainly in describing its evolution over time globally and according to the initial presentation, genotype-phenotype correlations and heritability of the disease, real life management of patients and its impact on cure and survival for each type of MEN1-related tumor and impact on the patients' daily lives, their perception of the disease and their satisfaction with their care. 

May 20, 2019

Tanta University is conducting an Interventional trial in 100 participants in order to utilize Dexmedetomidine as a Sedative Agent for Patients Presented for Lower Gastrointestinal Endoscopy, 

May 20, 2019

Stanford University is conducting an Interventional in 20 participants in order to evaluate the detection of cardiac sarcoidosis or inflammation using 18F-FSPG PET/MRI. PET/MRI scans will be performed with a whole-body PET/MR imaging system capable of simultaneous PET and MR imaging. 

Publications

May 22, 2019

Archives of Disease in Childhood (ADC) is an international and peer-reviewed journal specialising in child health, covering the perinatal period through to adolescence.  As an official journal of the Royal College of Paediatrics and Child Health, ADC provides paediatricians with the most recent, relevant and original research reports, commentaries, clinical and policy reviews, and education.

May 22, 2019

Heart and Vessels is an English-language journal that provides a forum of original ideas, excellent methods, and fascinating techniques on cardiovascular disease fields. The current issue consists of articles on maintenance of atrial fibrillation, pharmacodynamics of prasugrel and clopidogrel etc. 

May 22, 2019

BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.

May 22, 2019

Inflammatory Bowel Diseases is a peer reviewed monthly journal dedicated to current issues and updates in the field of Gastroenterology. The journal provides insight regarding new treatment methods, management strategies of common Gastroenterological disorders. 

May 22, 2019

Journal of Radiotherapy in Practice is a peer-reviewed journal covering all of the current modalities specific to clinical oncology and radiotherapy. The journal aims to publish research from a wide range of styles and encourage debate and the exchange of information and opinion from within the field of radiotherapy practice and clinical oncology. The journal also aims to encourage technical evaluations and case studies as well as equipment reviews that will be of interest to an international radiotherapy audience.

May 17, 2019

Journal of Diabetes Science and Technology (JDST) is a bi-monthly, peer-reviewed scientific journal published by the Diabetes Technology Society (DTS). JDST covers scientific and clinical aspects of diabetes technology, the development and use of mobile applications and wireless communication, as well as bioengineered tools. Articles cover both basic research and clinical applications of technologies being developed to help people with diabetes.

May 17, 2019

Reviews in Clinical Gerontology brings together specially commissioned international reviews on recent developments in geriatric medicine (including rehabilitation, nursing care and psychiatry of old age) and in biological, psychological and social gerontology. There is systematic coverage of the literature on a cyclical basis. All the major topics of interest are reviewed during the course of a five-year cycle. The issues build into a valuable source of reference for everyone working with elderly people.

Videos

May 22, 2019

Prof Graham Ogg speaks about the research his specialty covers. Topics covered include the impact skin conditions can have on patients' lives; taking blood samples from patients with skin diseases to further understand their conditions and clinical trials of new drugs for eczema, psoriasis and skin cancer.

May 22, 2019

The NIHR Medtech and In vitro diagnostics Co-operatives have supported Mologic Ltd, a UK-based SME, in its development of a urine-based test for an early indication of exacerbation of COPD, simple enough for patients to monitor their disease status at home, enabling care in the community reducing A&E visits and admissions.

May 19, 2019

Prof. Christian Gratzke elaborates what the significance of medical treatment today is and talks about the most promising developments in lower urinary tract symptoms (LUTS) which arise as a result of benign prostatic enlargement (BPE).

May 19, 2019

Stanford University's Victor G. Carrion, MD, discusses the neuroscience of pediatric trauma and the use of the cue-centered therapy approach for youth with post-traumatic symptoms. The cue-centered therapy is an evidence-based treatment program designed to treat children with repeated trauma exposure.

Case Studies

Aug 05, 2019

This is a case of a 58 years old man with severe mucous membrane pemphigoid (MMP) who presented with onychomadesis. He presented with 2 years history of recurrent painful mouth sores and cutaneous blisters on his extremities and genital area. The patient was initially treated with 1 mg/kg of prednisone which resulted in rapid control of his symptoms but when the dose was tapered to 0.5 mg/kg the patient showed signs of disease recurrence. 2 g/kg/cycle of intravenous immunoglobulin therapy IVIG was added. The patient received three cycles on a monthly interval and showed remarkable improvement.

May 22, 2019

This is a case of a 67-year-old woman, sigmoid colon cancer was incidentally detected on preoperative upper gastrointestinal endoscopy. Endoscopy revealed a slightly elevated lesion at the minor duodenal papilla. The findings of a histopathologic examination were suggestive of adenocarcinoma. Computed tomography and magnetic resonance images identified a minute tumor, whereas endoscopic ultrasonography revealed that the tumor did not spread to the pancreas. Doctors performed endoscopic mucosal resection (EMR) of this lesion. There were no complications, and relapse has not occurred in 3 years. 

May 22, 2019

This is a case report of a spontaneously regressed myxofibrosarcoma successfully treated by resection where the extent of the tumor was determined from the initial MRI. This case demonstrates that myxofibrosarcoma has the potential to regress spontaneously, and an astute awareness of this phenomenon is necessary for appropriate management of this condition.

May 22, 2019

This is a case of a 27-year-old man presented with alveolar hemorrhage secondary to inhalation of synthetic cannabinoid. The patient developed hemoptysis and respiratory failure 48 hours after the inhalation. A urine and blood toxicology screen were negative for cannabinoid. Bronchoscopy was performed and showed oozing of blood from all right lung airways and the left lower lobe bronchus. The patient was empirically treated with high-dose steroid for 3 days, followed by prednisone 40 mg/day that was tapered to 10 mg/day over 4 days and then discontinued. Over the 48 hours after corticosteroid administration, his oxygenation improved significantly.