This is a case of 25-year-old male with a past medical history of sickle cell disease presented with a lump in his left neck for a few months. A CT scan showed bilateral cervical adenopathy with a 7 cm predominant lymph node in the left cervical area. The pathology of excision biopsy showed Epstein-Barr Virus-positive Reed-Sternberg cells and read as classical Hodgkin lymphoma, mixed cellularity type. The patient was treated with chemotherapy (ABVD regimen) & radiation therapy.
Sickle cell disease (SCD) is an inherited disorder of hemoglobin mutation in red blood cells, with a patient population that is increasing in an age in recent decades due to advances in modern medicine. Hodgkin’s lymphoma (HL) is a cancer of white blood cells, and while concomitance of SCD and Hodgkin’s has been reported, a discussion of treatment for HL in SCD is lacking from the literature. We present a case of effectively treated HL in SCD and put forth that the regimen used is a practical choice, and as it was completed fully as an outpatient, it improved the patient’s quality of life compared to an inpatient regimen.