Volumetric Modulated Arc Therapy (VMAT) for Hippocampal-avoidance Whole Brain Radiation Therapy

Journal of Medical Case Reports
24 Feb, 2020 ,

Despite providing palliation and prophylaxis, whole-brain radiation therapy (WBRT) reduces local recurrence probability and improves overall survival, it is evident that WBRT is linked to neurocognitive deficits due to radiation-induced damage of the hippocampus. Therefore, minimizing the hippocampal dose to the least possible level is of high clinical relevance. Adams Hei Long Yuen et al investigated the potential of a radiation therapy technique with split-arc and reduced field size, namely split-arc partial-field volumetric modulated arc therapy (sapf-VMAT) to spare the hippocampus during WBRT.