Antihistamines Are Synergistic With Bruton’s Tyrosine Kinase Inhibiter Ibrutinib Mediated By Lysosome Disruption In Chronic Lymphocytic Leukemia (CLL) Cells

Leukemia Research
31 Jul, 2020 ,

AaronChanas-Larue conducted a study to assess if that three over-the-counter antihistamines, clemastine, desloratadine, and loratadine, preferentially induce cell death via lysosomal membrane permeabilization in chronic lymphocytic leukemia cells, as compared to normal lymphocytes. The researchers concluded that  potential novel treatment strategy forchronic lymphocytic leukemia, repurposing FDA-approved allergy medications in combination with the targeted therapy ibrutinib to enhance drug efficacy.