Williams DM, et al. performed two-sample Mendelian randomization analyses to investigate if Alzheimer disease (AD) risk would be lower in individuals with lifelong, genetically predicted increases in concentrations of 4 circulating antioxidants that are modifiable by diet. No reduction in AD risk was suggested in relation to higher exposure to ascorbate, β-carotene, retinol, or urate. There was little evidence to imply that pleiotropy had biased results.
The American Journal of Clinical Nutrition