Circulating Antioxidants and Alzheimer Disease Prevention

The American Journal of Clinical Nutrition
13 Jan, 2019 ,

Williams DM, et al. performed two-sample Mendelian randomization analyses to investigate if Alzheimer disease (AD) risk would be lower in individuals with lifelong, genetically predicted increases in concentrations of 4 circulating antioxidants that are modifiable by diet. No reduction in AD risk was suggested in relation to higher exposure to ascorbate, β-carotene, retinol, or urate. There was little evidence to imply that pleiotropy had biased results.

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