Diagnostic Accuracy of γ-Glutamyl Transpeptidase-to-Platelet Ratio for Predicting Hepatitis B-Related Fibrosis

European Journal of Gastroenterology and Hepatology
02 Apr, 2019 ,

Lian et.al. conducted a study to assess he performance of γ-glutamyl transpeptidase-to-platelet ratio for diagnosing HBV-related significant fibrosis, severe fibrosis, and cirrhosis. The researchers concluded that moderate diagnostic accuracy for predicting HBV-related significant fibrosis and further studies with larger sample size are required. 

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Background and aim Emerging published data on the accuracy of γ-glutamyl transpeptidase-to-platelet ratio (GPR) for diagnosing hepatitis B virus (HBV)-related fibrosis are inconsistent. The aim of this study was to systematically review the performance of GPR for diagnosing HBV-related significant fibrosis, severe fibrosis, and cirrhosis.

Patients and methods A comprehensive literature search of PubMed, Web of Science, and EMBASE was conducted before July 2018. Study selection was performed according to inclusion and exclusion criteria. The relevant parameters of eligible studies were abstracted. The methodological quality was assessed according to the Quality Assessment of Diagnostic Accuracy Studies. Areas under summary receiver operating characteristic curves, sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratios were used to examine the GPR accuracy for the diagnosis of significant fibrosis, severe fibrosis, and cirrhosis.

Results A total of 10 studies including 5882 patients with HBV infection underwent liver biopsy were incorporated. The prevalence of significant fibrosis, severe fibrosis, and cirrhosis were 58% (range: 22–72%), 36% (range: 10–55%), and 19% (range: 2–33%), respectively. Areas under summary receiver operating characteristic curves of GPR for predicting significant fibrosis, severe fibrosis, and cirrhosis were 0.733, 0.777, and 0.796, respectively. Subgroup analysis was performed according to geographical region and histological scoring system with similar results.

Conclusion GPR has moderate diagnostic accuracy for predicting HBV-related significant fibrosis, severe fibrosis, and cirrhosis, and further studies with large sample size, rigorous design, multicenter study population are urgently needed.