Familial History of Heart Disease And Increased Risk For Elevated Troponin In Apparently Healthy Individuals

Clinical Cardiology
11 Jun, 2019 ,

Noa Cohen et.al. conducted a study to understand if Family history of heart disease associated with elevated High sensitive cardiac troponin T in apparently healthy individuals. They concluded that there was a significant association further leading to believe that an inflammatory process may be involved in this association.

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Background

Family history of heart disease (FH‐HD) is associated with an increase drisk of subsequent HD. High sensitive cardiac troponin T (hs‐cTnT) is arecognized biomarker of myocyte injury even in HD free patients. We examined the association between FH‐HD and hs‐cTnT in apparently healthy individuals.

Hypothesis

FH‐HD is associated with elevated hs‐cTnT in apparently healthy individuals.

Methods

In a cross sectional study we analyzed data of apparently healthy individuals (n=3,821) recruited for the Tel‐Aviv Medical Center Inflammation Survey (TAMCIS). Blood samples were obtained for hs‐cTnT and high sensitive CRP (hs‐CRP) among other tests. FH‐HD was defined as first degree family member with HD diagnosis and classified as premature if the diagnosis was done before the age of 55 for men or 65 for women.

Results

Elevated hs‐cTnT (>14 ng/L) was more common in FH‐HD of any age, and in premature FH‐HD (FH‐P‐HD) participants than in participants without FH‐HD (4.4% vs 2.0%, p<0.001 and 4.3% vs 2.0%, p=0.001, respectively). Adjustmentfor potential risk factors with association to elevated hs‐cTnT (age, sex, BMI, hypertension, diabetes, hs‐CRP, smoking and physical activity), showed that FH‐HD and FH‐P‐HD remained significantly associated with elevated hs‐cTnT (OR=1.62, p=0.025 and OR=1.70, p=0.039, respectively). Furthermore, we found that a significant interaction between FH‐HD or FH‐P‐HD and high levels ofhs‐CRP (>3 mg/L) increased the risk for elevated hs‐cTnT (OR=3.07, p=0.036 for FH‐HD and OR=3.25, p=0.053 for FH‐P‐HD).

Conclusions

FH‐HD and its interaction with elevated hs‐CRP levels were significantly associated with elevated hs‐cTnT in apparently healthy individuals suggesting that an inflammatory process may be involved in this association.