Genetic Polymorphism Predicting Methotrexate Efficacy In Chinese Patients With Psoriasis Vulgaris

Journal of Dermatological Science
08 Feb, 2019 ,

This study is to analyze the genetic polymorphism to predict methotrexate efficacy in Chinese patients with psoriasis vulgaris. They used the whole exon high-throughput sequencing technology to detect the DNA sequence of 22 psoriasis vulgaris patients (11 responders, 11 non-responders) treated with methotrexate. They found 3 new SNPs that could predict the efficacy of methotrexate in psoriasis vulgaris to some extent, providing a theoretical basis for precision medicine of methotrexate in the future.