Knocking Out Matrix Metalloproteinase 12 Causes The Accumulation Of M2 Macrophages In Intestinal Tumor Microenvironment Of Mice

Cancer Immunology, Immunotherapy volume
10 Jul, 2020 ,

Mingming Yang conducted a study to assess whether macrophages would change in the intestinal tumor microenvironment after MMP12 knockout. The researchers concluded that knocking out MMP12 accelerated the tumor growth and pathological process. On further investigation of its mechanism, the proportions of M2 macrophages in the spleen and among peritoneal macrophages were significantly up-regulated in ApcMin/+;MMP12−/− mice.