Methotrexate for the Treatment of Recalcitrant Erosive Lichen Planus of the Vulva

JAMA Dermatology
09 Jan, 2020 ,

Abigail Cline, MD, PhD et al retrospectively reviewed medical records at a vulvar clinic in order to assess the effectiveness of treatment with methotrexate (MTX) in females with Erosive lichen planus of the vulva (ELPV) (characterized by desquamative, erosive dermatitis involving the vulva and vagina). Management of ELPV was defying, with topical corticosteroids, almost 25% of individuals had ELPV that was resistant to first-line therapy. Some studies of ELPV were shown that the management of recalcitrant ELPV tough. Specifically, for the treatment of recalcitrant ELPV, limited evidence was available on MTX.

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Erosive lichen planus of the vulva (ELPV) is a subtype of lichen planus characterized by desquamative, erosive dermatitis involving the vulva and vagina. Management of ELPV is challenging; almost 25% of patients have ELPV that is resistant to first-line therapy with topical corticosteroids. There are very few studies of ELPV, which makes management of recalcitrant ELPV difficult. Specifically, little evidence is available on methotrexate (MTX) for the treatment of recalcitrant ELPV. The aim of this study was to retrospectively review medical records to evaluate the efficacy of treatment with MTX in women with ELPV at a vulvar clinic.