New Insight Of miR-612 on Tumor Metastasis and Progression

Journal of Hematology & Oncology
11 Feb, 2020 ,

MiR-612 has been proven to suppress EMT, tumor metastasis and stemness of hepatocellular carcinoma, but its biological roles on HCC progression are far from elucidated. Yang Liu et al performed several in-vitro and in-vivo models to explore its biological characteristics, potential molecular mechanism as well as its clinical relevance in HCC patients. Their findings not only suggested that miR-612 can suppress the formation of invadopodia, EMT and HCC metastasis but might also provide a new insight of miR-612 on tumor progression and metastasis.