PD-1+ Natural Killer Cells In Human Non-Small Cell Lung Cancer Can Be Activated By PD-1/PD-L1 Blockade

Cancer Immunology, Immunotherapy volume
10 Jul, 2020 ,

Marcel P. Trefny et.al. conducted a study to assess that ntratumoral Natural killer cells from Non-Small Cell Lung Cancer patients expressed elevated levels of the immune checkpoint receptor PD-1 on their cell surface. The researchers concluded that therapeutic potential of PD-1+ Natural killer cells in immune checkpoint blockade and could guide the development of Natural killer cell-stimulating agents in combination with PD-1 blockade.