Pulmonary Nodule Enhancement In Subtraction CT And Dual-energy CT: A Comparison Study

European Journal of Radiology
28 Nov, 2020 ,

Dagmar Grob et.al. conducted a retrospective analysis to compare nodule enhancement on subtraction CT iodine maps to that on dual-energy CT iodine maps. For the analysis, datasets of lung subtraction and dual-energy CT maps from 30 patients with 95 solid pulmonary nodules were used and it was seen that nodule enhancement at subtraction CT was “highly visible”. From the comparison, it could be inferred that subtraction CT is superior to dual-energy CT in depicting iodine enhancement in pulmonary nodules.

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Abstract

Objective

To compare nodule enhancement on subtraction CT iodine maps to that on dual-energy CT iodine maps using CT datasets acquired simultaneously.

Methods

A previously-acquired set of lung subtraction and dual-energy CT maps consisting of thirty patients with 95 solid pulmonary nodules (≥4 mm diameter, 72 malignant) was used. Nodules were annotated and segmented on CT angiography, and mean nodule enhancement in the iodine maps calculated. Three radiologists scored nodule visibility with both techniques on a 4-point scale.

Results

Mean nodule enhancement was higher (p < 0.001) at subtraction CT (34.9 ± 12.9HU) than at dual-energy CT (25.4 ± 21.0HU). Nodule enhancement at subtraction CT was judged more often to be “highly visible” for each observers (p < 0.001) with an area under the curve of 0.81.

Conclusions

Subtraction CT is able to depict iodine enhancement in pulmonary nodules better than dual-energy CT.