Syntenin-1 Promotes Colorectal Cancer Stem Cell Expansion And Chemoresistance By Regulating Prostaglandin E2 Receptor

British Journal of Cancer
30 Jun, 2020 ,

Kazuya Iwamoto conducted a study to investigate the involvement of syntenin-1 in colorectal cancer , we performed immunohistochemical analysis of 139 colorectal cancer surgical specimens. The researchers concluded that that syntenin-1 enhanced cancer stem cells expansion, oxaliplatin chemoresistance and migration capability through regulation of PTGER2 expression. Syntenin-1 may be a promising new prognostic factor and target for anti-cancer therapies.