A Tropism-Transformed Oncolytic Adenovirus With Dual Capsid Modifications For Enhanced Glioblastoma Therapy

Journal of Cancer
30 Jul, 2020 ,

Lizheng Wang et.al. conducted a study to develop a novel oncolytic adenovirus for enhanced infectivity and therapeutic efficacy toward glioblastoma. The researchers concluded that gene therapy mediated by the dual-modified oncolytic Ad5 vector coupled with the tumor necrosis factor-related apoptosis-inducing ligand exhibited significantly enhanced anti-tumor efficacy in vitro and in vivo