The purpose of this Phase 1, multicenter, open-label study is to determine the maximum tolerated dose (MTD) of AG-636 and characterize its dose-limiting toxicities (DLTs) when given by mouth to subjects with advanced lymphoma that is refractory to standard treatment. During the dose-escalation part of the study successive cohorts of subjects will be treated with increasing doses of AG-636 in order to determine its maximum tolerated dose (MTD). Subsequently, in the dose-expansion part of the study, additional subjects will be treated at the MTD in order to confirm that dose's safety, tolerability, PK and PD, and to provide an opportunity to detect anti-lymphoma activity. The dose expansion part of the study will support the selection of a dose for future clinical studies (a recommended Phase 2 dose [RP2D]).
Researchers performed a systemic study to calculate the proportion receiving systemic steroids within 7 days of the ARTI diagnosis along with its predictors. The researchers concluded that utility of systemic steroid in ARTI is common with a great geographical variability. It calls for an effective education program about this practice, which does not have a clear clinical net advantage.
Researchers evaluated clinical benefit in patients who are suffering from chronic refractory gout but did not meet the protocol-defined criteria of responders to pegloticase. They concluded that pegloticase treatment afforded significant clinical benefits among chronic refractory gout patients not achieving protocol-defined persistent urate lowering.
EMA after a new evidence based review mentioned that the use of Fosfomycin should only be limited when other antibiotic treatment is not available. The EMA explains in a statement that Fosfomycin-based antibiotics have been available since the 1960s, but their use has decreased in favor of other antibiotics.
A group of child development and social policy researchers wrote in the Lancet that parenting and teaching children during the COVID-19 pandemic may be difficult, but this time can also lead to creative opportunity. Parenting can support children's development, and parenting programs such as these can be used in contexts of poverty and stress, the researchers added. Their tips and content is being translated into 55 languages.
Recent literature has shown that despite being well prepared, many recently graduated family physicians do not provide the services they learned in residency. 97.15% of recently graduated family physicians feel that their residency adequately prepared them at least one of the reproductive health procedures but the number of family physicians that currently deliver those services substantially declines in practice.
According to a study published in Lancet Infectious Diseases, the fatality ratio across the spectrum of COVID-19 disease and show a strong age gradient in risk of death. The fatality rate rises with age, from well below 1% among children aged 9 years or younger to nearly 8% for seniors aged 80 years or older, the latest statistics show.
According to a case report Vaping and tetrahydrocannabinol use might be associated with the development of eosinophilic pneumonia and lymphadenopathy. Eosinophilic pneumonia often presents in previously healthy individuals with many symptoms and findings consistent with those of an infectious etiology, and frequently leads to difficulty discerning between the two disease processes initially, resulting in a delay in the appropriate therapy.
Researchers examined if the ability of antimüllerian hormone to distinguish between women with (cases) and without (controls) polycystic ovarian syndrome (PCOS) improves when a woman’s age and body mass index are accounted. They found that significantly higher AMH-based detection rates for PCOS were observed when the woman’s age and BMI were accounted; the detection rates had a 10% false-positive rate.
According to a letter published in Lancet Neurology, they believe that social media could expand the number of mentors for female medical students, raise awareness about the rewards and challenges of becoming a neurosurgeon. It is the need of the hour as even though the proportion of female doctors in the United Kingdom has increased every year over the past decade, women surgeons remain a minority.