According to a new study, periodontitis is associated with significantly higher blood pressure in otherwise healthy individuals. "Oral diseases are often overlooked and only when acute problems arise do they trigger a visit to the dentist," said senior study author Francesco D'Aiuto, head of the Periodontology Unit at the University College London Eastman Dental Institute, in the UK.
In a phase 3 trial, first-line tebentafusp has been demonstrated to have an overall survival of 21.7 months in patients with metastatic uveal melanoma; longer than with immunotherapy or chemotherapy. Tebentafusp is a bispecific fusion protein that targets gp100 through a high affinity T-cell receptor binding domain and an anti-CD3 T-cell engaging domain. The limitation with tebentafusp is that it can only be used to treat HLA-A*02:01-positive patients as the T-cell receptor binding domain only recognizes a specific gp100-derived peptide presented on HLA-A*02:01. Pyrexia, pruritus and rash are the most common adverse effects associated with the use of tebentafusp.
Nadia Ansari et al. report the case of a 5-month-old boy who presented with esotropia of the right eye. He was seen to have light perception vision in the right eye and normal fix and follow vision in the left eye on examination. In addition to that, slightly pale optic nerves and multiple atrophic and hyperpigmented lesions were seen along the vascular arcades and maculae in both eyes. A head CT scan revealed regions of volume loss within the cerebral hemispheres and supratentorial white matter along with multiple foci of dystrophic calcification. On obtaining a history of exposure to rodents during pregnancy, LCMV titers were ordered which demonstrated a positive IgG titer consistent with a remote LCMV infection.
Richard Gale et al. sought to examine whether anti-vascular endothelial growth factor for the treatment of macular oedema secondary to branch retinal vein occlusion is as beneficial in the real world as was demonstrated in clinical trials. Data from 5661 treatment-naive patients who either underwent anti-vascular endothelial growth factor therapy (anti-VEGF), intravitreal dexamethasone, or macular laser show that visual acuity improvements were higher and more sustained with anti-VEGF.
According to a recent research, a new study has found that Older cognitively healthy adults with more harmful than healthy bacteria in their gums are more likely to have biomarkers of amyloidosis in their cerebrospinal fluid. "Our study showed for the first time an association between subgingival (under the gum line) bacteria and reduced cerebrospinal fluid amyloid-beta in cognitively normal elderly people. The uniqueness of our findings is showing the importance of the balance between healthy and harmful bacteria in the homeostasis of amyloid-beta," said the researchers.
Mandy Oi Man Won et al. carried out a study aimed at comparing the IOP lowering effect and safety of pattern scanning laser trabeculoplasty (PSLT) with selective laser trabeculoplasty (SLT) in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT). The study involved periodic measurement of IOP for 12 months of 132 patients who underwent either PSLT or SLT. It was found that IOP measurements were comparable between the groups over 12 months indicating that PSLT was nonsuperior to SLT in terms of safety and IOP-lowering efficacy in patients with POAG or OHT.
A study assessing the prescribing habits of dentists in Australia, British Columbia, Europe and the United States found that dentists in the U.S. prescribed the most antibiotics per population. They prescribed twice as many antibiotics as dentists in Australia, who prescribed the fewest, researchers reported. The study came together at the 2019 International Association for Dental Research general session in Vancouver, where Wendy Thompson, PhD, professor of dentistry at the University of Manchester in England, organized and chaired a symposium on dental antimicrobial stewardship.
Flavia Lamberghini et.al. conducted a study to investigate the positivity rate of asymptomatic SARS-CoV-2 infection in pediatric dental patients. The researches concluded that although the yield of testing was low, the systematic evaluation of asymptomatic pediatric dental cases via PCR resulted in the identification of SARS-CoV-2 carriers who could have been infectious.
Rim Kallala et.al. presented a reviewe of a 34-year healthy female patient who consulted for rehabilitation of the left first lower molar. The purpose of this paper was to detail the protocol of chairside system and provide a useful evaluation tool, through a clinical case carried out in the dental clinic of the Faculty of Dental Surgery Paul Sabatier Toulouse.
PreserFlo, made from SIBS, when implanted intraoperatively with 0.2 mg/mL to 0.4 mg/mL mitomycin C has been found to reduce IOP in patients with primary open-angle glaucoma. In a study, a reduction in IOP from 21.1 mm Hg to 14.2 mm Hg at month 12 could be achieved with the use of the device. Owing to the smoother bleb and its more posterior position, the associated risk for fibrosis, ocular surface issues and late-onset bleb complications is low.