A study suggests that thiopurines were associated with an increased risk for non-infectious and non-neoplastic adverse events in patients older than 60 years of age who had IBD. The researchers also foundthat older age and female sex were independent risk factors for most adverse events.
A systematic review and meta-analysis reveals that mpMRI combined with targeted biopsy was associated with improved detection of clinically significant prostate cancer in comparison to transrectal ultrasonography-guided systemic biopsy alone. This research has concluded that mpMRI in the diagnostic pathway for prostate cancer may avoid unnecessary biopsies for some men and may lead to reduced side effects.
A federal judge has ruled that Wisconsin’s Medicaid program must cover gender affirmation health care in a major win for transgender Wisconsinites. Four transgender people sued the state’s Department of Health Services for denying coverage because of a 1998 law that bans using Medicaid money for “transsexual surgery.” U.S. District Judge William Conley ruled that the state had to cover gender affirmation health care because it’s an accepted treatment for gender dysphoria.
Vizient in its recent findings revealed that Drug Price Forecast, predicts a continued growth of pharmaceutical costs that far exceeds both inflation and wage growth. These advances provide choice and potentially improved outcomes, providers and patients will now experience a financial impact due to the standard of care shifting from mostly inexpensive, generic agents to combinations of branded targeted agents.
According to a research letter published in JAMA Pediatrics, that the legalization of marijuana may actually help to curb use among teenagers. Even though the research team wasn't able to pin down the precise mechanism for the decline in marijuana use, but they suggested that obtaining marijuana with legal license is more difficult than from drug dealers.
A recent analysis suggests that a biomarker-based approach can be effective in identifying a gradient of risk among post-ACS patients who would most benefit from the addition of ezetimibe to statin therapy. The researchers reported that there was an independent association between elevated levels of each biomarker with greater risk for Cardiovascular death, Myocardial Infarction and stroke and Cardiovascular death and Heart Failure.
A study suggests that Use of lipophilic but not hydrophilic statins lead to significantly lower risks for hepatocellular carcinoma and deaths in pateints who had chronic viral hepatitis. The benefits of lipophilic statins were that of dose- and duration-dependent. Reduction in risk occurred after at least 600 cumulative defined daily doses.
The researchers discovered for the first time that Bcl11b, a transcription factor, determines which class of odorant receptor (OR) gene is expressed in olfactory neurons. In the absence of Bcl11b, olfactory neurons are fated to class I. But the fate can be switched to class II in the presence of Bcl11b. This also corroborates the idea that class I OR is the default OR, which undergoes a transcriptional switch in the presence of Bcl11b.
A new study finds that melanoma brain metastasis occurs when tumor cells "hijack" an inflammatory pathway in the brain. Blocking this pathway could prevent these metastases from developing, according to the research. The scientists utilized a mouse model of spontaneous melanoma brain metastasis to study the interactions of melanoma tumors within the brain microenvironment. They discovered that melanoma brain metastasis is facilitated by the takeover of a physiological inflammatory pathway by astrocytes, the brain cells that maintain a protected environment in the brain.
In a new study, investigators in China found that bacterial genera in children were more similar to those of their own mothers than to those of unrelated women. Their data suggest that the mode of delivery at birth could be an important factor in shaping the child's microbiome.