Research Desk

Oct 18, 2019

The Food and Drug Administration announced today that in the year 2019 the agency has approved about 1,171 generic drugs which is an all time record in itself. The FDA added further that Generic drugs account for about 90% of all prescription drug purchases in the U.S and this has lead to savings to the healthcare system totaling an estimated $293 billion in the past. 

Oct 18, 2019

The findings of the large STOP PD-II clinical trial suggest that patients with psychotic depression should continue use of antipsychotics in combination with antidepressants for at least four months following remission of symptoms.

Oct 18, 2019

Two studies reported at the 2019 Digestive Disease Week found that surveillance intervals often are too short, possibly putting patients at risk for harm from unnecessary interventions.

Oct 18, 2019

As the number of cases have ballooned to now 1,299 across the nation, experience has grown such that the agency released official interim guidance for clinicians on what it's now calling EVALI (e-cigarette, or vaping, product use-associated lung injury).

Oct 17, 2019

Two new surveys indicate that there is a  possible discrepancy between hospital executives' high-level view of the importance of clinical integration to supply chain and financial performance along with the effectiveness of the actual on-the-ground approaches taking place in many health systems. This raises the question if majority of health systems have a unified cost management high-level goals are actually being conveyed to the front. 

Oct 17, 2019

Northwestern Medicine scientists have used patient-derived neurons to develop and test a new strategy to treat Parkinson's disease by mitigating the effects of harmful genetic mutations, as detailed in a recent study. Their study highlights wild-type GCase activation as a potential therapeutic target for multiple forms of Parkinson's disease. 

Oct 17, 2019

Researchers at the University of Illinois at Chicago are the first to identify the presence of a specific type of antibody, called anti-citrullinated protein autoantibodies, or ACPAs, in human tear fluid. They are also the first to demonstrate that patients with dry eye disease experienced reduced signs and symptoms of the condition in response to a new eye drop treatment –— made from pooled human antibodies — that targets ACPAs.

Oct 17, 2019

All randomized controlled trials examining individuals treated with gemcitabine (one of many treatments that could be used both as single-agent or as combination therapy for the treatment of recurrent ovarian cancer) for recurrent ovarian cancer and reporting data on overall survival, progression-free survival and toxicity were involved in this systematic review and meta-analysis. Six randomized controlled trials that assessed gemcitabine either alone or as combination therapy were involved. The results exhibited that gemcitabine is an active and safe agent in the treatment of both platinum-sensitive and resistant recurrent ovarian cancer although it might reflect the necessity of new randomized studies in massively pretreated individuals.

Oct 17, 2019

There is no effective vaccine currently available to prevent Lyme disease in humans. Experts from academia, government, and industry convened at Cold Spring Harbor Laboratory's Banbury Center to tackle this public health challenge. Now, a new paper highlights the conference discussions, reiterates the need to stop the infection, and defines a strategy for developing effective vaccines. "Countermeasures such as vaccines are needed to stem the growing number of cases per year," said Dr. Steven Schutzer, a senior author on the paper and physician-scientist at Rutgers New Jersey Medical School. "This is extremely important because you can get Lyme disease more than once."

Oct 17, 2019

Insulin is normally produced by pancreatic beta cells. In many people with diabetes, pancreatic cells are not functional, causing a chronic and potentially fatal insulin deficiency that can only be controlled through daily insulin injections. However, this approach has serious adverse effects. In order to improve therapy, researchers have identified a protein called S100A9 which seems to act as a blood sugar and lipid regulator while avoiding the most harmful side effects of insulin.