Research Desk

Feb 14, 2019

Speakers who took part in pharma forum of HIMSS19 believe that Payers and pharma might be in early stages of collaboration. Even though there has been a rise in such types of agreement, there are still a lot of hurdles in legal compliance and considerations which further make data collection and linking difficult. 

Feb 14, 2019

The insulin-sensitizing agent pioglitazone (Actos) appeared effective for secondary prevention in stroke patients with prediabetes, according to a post hoc analysis of the IRIS randomized clinical trial. The diabetes endpoint was based only on fasting glucose levels and patient reports. The researchers also did not perform hemoglobin A1c testing after baseline visits and did not include oral glucose tolerance testing as part of the protocol.

Feb 14, 2019

When a car crash or explosion results in an optic nerve injury, eliminating an enzyme known to promote inflammation appears to aid recovery, scientists report. They have shown for the first time in a mouse model of tough-to-treat optic nerve trauma, that removing the enzyme arginase 2, which increases with injury, decreases neuron death in the retina as well as the degeneration of nerve fibers that connect neurons to each other and ultimately the brain.

Feb 14, 2019

Initial trials in humans found that a new drug, tisotumab vedotin(TV), shows significant promise in the treatment of persistent tumors in several late-stage cancers. What is so exciting about this treatment is that its mechanism of action is completely novel — it acts like a Trojan horse to sneak into cancer cells and kill them from the inside.

Feb 14, 2019

Men with infertility may have better-quality sperm when they take certain nutritional supplements and medicines, but there’s little evidence about whether that leads to pregnancies and births, a research review concludes. This systematic review has identified several medical and nutritional treatments options that appear to improve semen parameters.

Feb 13, 2019

A new study suggests that rate of road accidents decline in kids with Sleep Apnea if they use PAP therapy at night. According to numbers 5% on Non-Obese and upto 40% of Obese children suffer from Sleep Apnea. About 6000 pedestrians in the US are killed each year due to road accidents. 

Feb 13, 2019

According to a study published in PLOS ONE, about five metabolites were identified in a stress test conducted within two hours in patients with Myocardial Ischemia. The five metabolites that were identified were alanine, C14:1-OH, C16:1, C18:2 and C20:4. The study had a false positive rate of less than 0.2%.

Feb 13, 2019

Researchers measured serum zonulin and intestinal fatty acid binding protein levels in IBS-D patients, by using enzyme-linked immunosorbent assays and irritable bowel syndrome-symptom severity scale. They found that serum zonulin is upregulated and the levels were comparable to celiac disease. However no significant increase in enterocyte death was observed.

 

Feb 13, 2019

According to a study published in Radiology, an AI system can be helpful in interpreting as well as prioritizing X-Rays with abnormal findings. This would potentially be helpful in reducing the backlog of exams and bringing urgently needed care to patients more quickly. The researchers added that this will be extremely useful since there are no systematic and automated ways to triage chest X-rays. 

Feb 13, 2019

The FDA board, by a vote of 14-2, with one abstention, agreed on Feb. 12 that the benefits outweigh the risks of esketamine for treatment-resistant depression. Intranasal esketamine will be strictly regulated in the clinic, with federal monitoring requirements designed to prevent misuse, abuse, or diversion of the drug.