Study found that Serum phosphate levels higher than 1.78 mmol/L and calcium-phosphate product values exceeding 4.4 mmol2/L2 were associated with significant 1.8- and 2.1-fold increased risks for all-cause and cardiovascular mortality, respectively at the start of peritoneal dialysis.
The FDA board, by a vote of 14-2, with one abstention, agreed on Feb. 12 that the benefits outweigh the risks of esketamine for treatment-resistant depression. Intranasal esketamine will be strictly regulated in the clinic, with federal monitoring requirements designed to prevent misuse, abuse, or diversion of the drug.
Prophylactic intraperitoneal mesh implantation reduces hernia incidence but also brings increased early postoperative pain and prolonged wound healing after surgical site infections, according to a randomized clinical trial in patients with an elevated risk for incisional hernias.
Researchers find that the most common conditions among geriatric frequent users included diabetes (25.8%), chronic pulmonary disease (21.5%), kidney disease (19.1%), congestive heart failure (16%), and peripheral vascular disease (15.1%).
Baylor, Scott & White Health, Memorial Hermann have called off merger, officials from the systems confirmed. Even though no reason was given, a statement was issued that the systems shall seek further opportunities for collaboration. Both the systems will now chart new courses for their individual growth and future.
According to a new study, the immunotherapy drug pembrolizumab as the initial treatment for patients with a rare but aggressive form of skin cancer known as Merkel cell carcinoma reports better responses and longer survival than expected with conventional chemotherapy. In the 50-patient study of pembrolizumab as the initial treatment for patients with recurrent, locally advanced or metastatic Merkel cell carcinoma, more than half of the patients had long-lasting responses to the treatment & 12 of whom experienced a complete disappearance of their tumors.
A new 'seek-and-destroy' gene therapeutic system could have the potential to treat prostate cancer in the future. They developed a new 'seek-and-destroy' nanomedicine linked to an iron-carrying protein called lactoferrin, whose receptors are found in large amounts in many cancers. The results show that it is highly promising for the treatment of prostate cancer by gene therapy. The intravenous administration of the nanomedicine treatment resulted in the complete disappearance of 70% of the PC-3 tumors and half of the DU145 prostate tumors over one month.
This is a longitudinal study to observe the patterns of adenoid and tonsil growth in teenagers. The researchers obtained lateral cephalometric radiographies which are standardized and highly reproducible from 90 samples (same individuals) from a total of 23,133 patient database. For each individual, the adenoid and tonsil sizes were measured. The researchers found that the size of the adenoids and tonsils did not significantly vary among age groups, except when comparing the oldest with the youngest groups.
In the largest genetic study of osteoarthritis, scientists have uncovered 52 new genetic changes linked to the disease, which doubles the number of genetic regions associated with the disabling condition. In order to discover which genes cause OA, they incorporated additional functional genomic data and analyzed gene activity by measuring gene expression. Ten of the genes were highlighted as targets of existing drugs, which are either in clinical development or approved for use against OA.
The American Thoracic Society has developed a new clinical practice guideline for home oxygen therapy for children. "Home Oxygen Therapy for Children: An Official American Thoracic Society Clinical Practice Guideline" makes specific recommendations for treating chronic hypoxemia in children with cystic fibrosis, bronchopulmonary dysplasia etc.