In this study, they have evaluated the efficacy and safety of FOLFIRI maintenance treatment after FOLFIRINOX induction in a retrospective single-center study. Patients with advanced PDA treated with FOLFIRI as maintenance therapy after achieving disease control under FOLFIRINOX according to the local operating procedure between 2011 and 2016 were identified. Medical records of this group were evaluated retrospectively. In the selected group of PDA patients achieving disease control with FOLFIRINOX, FOLFIRI maintenance therapy was feasible, safe, and effective, with some patients achieving long-term disease stabilization.
This study is to evaluate the clinical effect of the second puncture and injection technique during a percutaneous vertebroplasty (PVP) procedure. The second puncture and injection technique may effectively increase the dispersion of cement, thus preventing recompression of the cemented vertebral body, and it does not increase the risk of cement leakage or adjacent vertebral fracture.
The aim of the study was to investigate the potential anti-inflammatory effects of exogenous surfactants on the bronchoalveolar lavage fluid, specifically alveolar macrophages of healthy South African children. This study provides the first data on the bronchoalveolar lavage of healthy South African children. Bronchoalveolar lavage fluid from patients with pulmonary inflammation was characterized by neutrophilia.
Lauren Bowen Reoma MD et al describe the first case of fatal JC virus (JCV) encephalopathy following immunosuppressive treatment that included ruxolitinib. Incorporating next generation sequencing, Sanger sequencing, tissue immunohistochemistry, and formalin-fixed hemisphere 7T magnetic resonance imaging, postmortem analysis was carried out. A new 12bp insertion that changed the transcription site binding pattern in an otherwise “wild-type virus,” which has long been presumed to be the nonpathogenic form of JCV, was revealed by JCV DNA isolated from postmortem tissue samples. The presence of infection in cortical neurons, hippocampal neurons, and glial and endothelial cells was shown by anti-VP1 staining. The findings of this case extend the spectrum of recognized JCV diseases related to broad-spectrum immunosuppression, including JAK-STAT inhibitors, as well as provide information about an additional neurotropic virus strain of the archetype variety.
Sarah Horton et al ascertained longer-term results of candidates recruited from a single center in the SYCAMORE trial, a randomized placebo-controlled trial of adalimumab vs placebo. For this investigation, they reviewed records of all 28 SYCAMORE candidates selected at the Bristol Eye Hospital at nearly 3-monthly intervals up to 5 years from the trial randomization date. After 1-2 years of treatment, drug-induced remission of JIA-U did not persist when adalimumab was withdrawn. According to this retrospective interventional case series, adalimumab has been well-tolerated and the outcomes of visual acuity have been outstanding.
Massimo Francesco Piepoli et al assessed the prognostic influence of serum uric acid (SUA) on long-term clinical outcomes in heart failure (HF). The relation between SUA and all-cause/cardiovascular deaths were examined in 4,577 individuals, with decreased ejection fraction HF, peakVO2 1,151 ± 440 ml/min, and NYHA class I-II, III-IV. SUA was found to be related to enhanced mortality, but only in less severe HF. Nevertheless, SUA did not explicate further prognostic power to the MECKI score.
Nader Shaikh et al identified more precise screening tests that could decrease the number of children who needlessly receive antimicrobials to treat a suspected UTI. A total of 200 children were enrolled; of these, 89 were later shown not to have a UTI based on results of the urine culture received. Urinary proteins involved in the inflammatory response may be beneficial in distinguishing pediatric patients with false positive results with current screening tests for UTI, and this may reduce unnecessary treatment.
Researchers attempted to investigate the current status of nutrition-support therapies by emergency physicians in China and provide an evidence-based case to improve the regulation of enteral and parenteral nutrition-support therapies. They concluded that emergency physicians should pay attention to early identifying and providing nutrition support to those patients who need it.
The clinical outcomes of second-generation zirconia restorations, including patients with bruxism clinical signs, and the material wear process was evaluated. It was found that monolithic zirconia FPDs are promising but the failure rate of single-unit restorations was not as high as expected in this sample including patients with bruxism clinical signs.
The potential relationship between elevated testosterone and polycystic ovary syndrome (PCOS) with regards to 24-hour urine metabolic panels and stone composition was studied. Compared to healthy stone formers, PCOS patients did not demonstrate significant differences in 24-hour urine and stone composition values. Elevated free testosterone in PCOS patients has a significant association with higher urinary citrate and sodium values.