Yao Lu et.al. conducted a study to analyze and compare the clinical and functional outcomes of distal tibia fractures treated with intramedullary nailing using the suprapatellar and infrapatellar surgical approaches. The researchers concluded that in the treatment of distal tibia fractures, the suprapatellar intramedullary nailing technique is associated with a significantly higher functional outcome, lower knee pain, and lower rate of fracture deformity than the infrapatellar intramedullary nailing technique.
K. Vanhaverbeke et.al. conducted a study to provide an overview of imaging techniques for detecting lung abnormalities in patients with Bronchopulmonary dysplasia in all age ranges. The researchers concluded that Several imaging and scoring methods indicate that lung imaging continues to play a role in Bronchopulmonary dysplasia care. Standardization and correlation with functional and clinical outcomes will become increasingly important for further research.
Fanqin Wei et.al. conducted a study to to develop an effective method of reducing metal artifacts in cochlear implant electrodes. The researchers concluded that the combination of single-energy metal artifact reduction with multi-planar reconstruction and maximum intensity projection is beneficial for evaluating the position and number of cochlear implant electrodes.
M. Co et.al. presented a study understand the association of breast implants and anaplastic large cell lymphoma as such an association has aroused public health concerns on breast implant safety. The researchers concluded that breast implants and anaplastic large cell lymphoma is an indolent disease that presents with seroma after implant insertion. A high index of suspicion is needed for early diagnosis and treatment.
Gaofeng Wang et.al. conducted a study to develop a bioinformatic gene signature score derived from skin mRNA to predict psoriasis treatment outcomes for a variety of therapies. The researcgers concluded that The psoriatic microenvironment score is a biometric score that may predict clinical efficacy of systemic psoriasis therapy in advance of clinical responses.
Vaishal M. Tolia et.al. reported the preliminary results of a targeted program of COVID-19 infection testing in the Emergency Departments in the first 10 days of its initiation at our institution. The researchers concluded that in this review of prospectively collected data on all Emergency Departments patients who had targeted testing for acute COVID-19 infection at two Emergency Departments in the first 10 days of testing, we found that 10.2% of those tested were identified as positive.
MacConmara et.al. conducted a study to impact of this emerging technology on donor liver utilization. The researchers concluded that Normothermic machine perfusion reduces the discard rate of procured livers despite its use in donors traditionally considered of more marginal quality.
Toshikazu Tanaka et.al. conducted a study to investigate the efficacy and safety of first‐line nivolumab plus ipilimumab for patients treated with metastatic renal cell carcinoma. The researchers concluded that treatment response to nivolumab plus ipilimumab is comparable with that of the CheckMate 214 clinical trial, but the incidence of treatment‐related adverse events is lower.
In patients with non–small cell lung cancer (NSCLC), a continuous rise in clinically relevant driver mutations has been seen over the years, and, due to the development of effective treatments, dysregulated activation of the MET tyrosine kinase receptor has acquired significance among these. Researchers undertook this review to address the biology of MET. They focused on the diagnosis of clinically relevant alterations and their growing clinical importance, taking into account the development of multiple targeted therapies, both within the context of MET as a driver of resistance and on its own. They found that via various mechanisms, including gene amplification, overexpression of the receptor and/or its ligand hepatocyte growth factor, and the acquisition of activating mutations, MET dysregulation can originate. Nearly 3% to 5% of patients with NSCLC, predominantly adenocarcinoma, were found to carry MET mutations. MET mutations were found to be overrepresented in the sarcomatoid subtype. In 1% to 5% of NSCLC cases, also mainly in adenocarcinoma, de novo MET amplifications were evident.
Researchers conducted this single-center, prospective, comparative case series to examine in vivo corneal changes of genetically confirmed Reis–Bücklers corneal dystrophy (RBCD) and Thiel–Behnke corneal dystrophy (TBCD) utilizing anterior segment optical coherence tomography (AS-OCT). Seven patients from 3 pedigrees (3 males, 4 females) with RBCD [Arg124Leu (R124L) heterozygous missense mutation of human transforming growth factor beta-induced (TGFBI) gene] and 4 patients from 3 pedigrees (3 males, 1 female) with TBCD [Arg555Gln (R555Q) heterozygous missense mutation of TGFBI gene] have been investigated. According to findings, the characteristic in vivo corneal microstructural changes associated with RBCD and TBCD can be clearly defined by AS-OCT. As a result, in vivo differentiation of RBCD and TBCD can be accomplished.