Research Desk

Apr 19, 2019

This study is aimed to evaluate the safety, tolerability and efficacy of nintedanib switched from pirfenidone in patients with idiopathic pulmonary fibrosis (IPF). A high incidence of early termination of nintedanib was noted when patients were switched from pirfenidone. Anorexia and weight loss during prior pirfenidone administration may increase the rate of the early termination of subsequent nintedanib treatment.

Apr 19, 2019

This multicenter retrospective study is to describe the various presentations and identify predictive factors of death in patients with Calciphylaxis (CPX). Cerium nitrate may lead to vascular decalcification and chelation of reactive oxygen species, and prevent infection. Cerium nitrate-silver sulfadiazine was associated with better outcomes and should be tested in a prospective comparative trial in CPX patients.

Apr 19, 2019

The study aims to report an experience with loop underlay tympanoplasty, a modification of the underlying technique previously reported, for the reconstruction of anterior, subtotal or total tympanic membrane perforations. The loop underlay technique combines the advantages of both underlay and overlay techniques with excellent postoperative outcomes.

Apr 19, 2019

A prospective, longitudinal, descriptive study was conducted from January 2016 to January 2018 to detect nerve dysfunction after hip arthroscopy. A total of 110 patients were included.  Twenty-four hours after surgery, 62.7% reported symptoms of abnormal sensation at least in one area. Nerve dysfunction after HA was more common than has been reported in the literature within large populations. Traction time was a significant factor in the development of perineal nerve dysfunction.

Apr 19, 2019

Here Bronte, et al. retrospectively analyzed ER, PgR, and AR expression on a case series of 159 specimens of primary BC samples by using immunohistochemistry and 89 patients of these had luminal tumors for which AR and ER expression and survival data were available. For twenty-four patients both primary and metastatic tumors were available.  In conclusion, these findings indicate that a prospective study is needed to better clarify the role of AR/ER ratio in different BC settings (i.e., adjuvant and metastatic). The relation between AR and PgR has to be better understood even if our findings suggest that a high AR/PgR ratio in luminal tumors is prognostically unfavorable and could be used as an additional risk-stratification marker. 

Apr 18, 2019

The most effective delivery format for Cognitive behavior therapy (CBT) was studied via a network meta-analysis. For acute symptoms of depression, group, telephone, and guided self-help treatment formats appeared to be effective interventions although guided self-help CBT may be less acceptable for patients than individual, group, or telephone formats.

Apr 18, 2019

Adding rib fixation during VATS in the management of retained hemothorax can contribute to shortening whole treatment courses, a team of researchers from Taiwan found. It also helped reduce pain, thus reducing dependence on analgesics.

Apr 18, 2019

Researchers from Canada came together to ascertain whether the iTClamp is equivalent to direct manual pressure (DMP) and Foley catheter balloon tamponade (BCT). They found that the iTClamp and BCT were associated with significantly less fluid loss in a neck hemorrhage than DMP in a perfused cadaver model. The iTClamp required significantly less time to apply than the BCT and were more effective than simple DMP. 

Apr 17, 2019

This study is to characterize and compare the cutaneous microbiome in 20 healthy controls and 23 patients with psoriasis using metagenomic analyses and to determine changes in the microbiome during treatment. Shifts in the cutaneous microbiome in psoriasis, particularly during treatment, may shed new light on the pathogenesis of the disease and may be clinically exploited to predict treatment response.

 

Apr 17, 2019

This systematic review was conducted to focuses on comparative studies of reconstruction with free flaps (FF) versus pedicled flaps (PF) after oncologic resection. A total of 30 articles were included. The comparison of both types of flaps is limited by the inherent design of the studies included. In sum, FF seems superior to the pectoralis major myocutaneous flap (PMMF) for several outcomes. Submental island flap (SMIF) and supraclavicular artery island flap (SCAIF) compare favorably to FF for some specific indications achieving similar outcomes at a lower cost.