Laura Pasin et al. performed a meta-analysis of studies to determine the effect of anakinra on survival and the need for mechanical ventilation in COVID-19 patients. The analysis included 4 observational studies involving 184 patients and it was concluded that the use of anakinra resulted in significantly lower mortality and lower risk of the need for mechanical ventilation than controls.
Nurdan Guldiken et al. conducted a study to determine whether serum transferrin reflects the activity of hepatocyte nuclear factor 4 alpha (HNF4α) activity. The study involved 40 patients with advanced liver disease from whom serum and liver samples were collected. Diminished HNF4α and transferrin protein levels in individuals with cirrhosis were demonstrated via immunohistochemical and biochemical tests. From the results of the study, it could be concluded that serum transferrin levels could be a prognostic and mechanistic biomarker and could serve as a surrogate of impaired hepatic HNF4α signalling and liver failure.
Sánchez Ríos Carla Paola et.al. conducted a study to assess the utility of collection a sample from of a respiratory tract at the adequate moment and from the correct anatomical site as it is essential for a rapid and precise molecular diagnosis with a false negative rate of less than 20%. The researchers concluded that Patients with COVID-19 and a persistently negative RT-PCR test with fatal outcomes did not diﬀer from the rest of the COVID-19 population since they present with the same risk factors shared by the rest of patients like lymphopenia, comorbidities, elevation of D-Dimer and DHL on admission as well as a tomographic COVID-19 score of severe illness, however we could suggest that the percentage of patients with a mild form of the disease is higher in those with a persistently negative RT-PCR test.
The study done by Matthias Ebner et al. attempted to determine the prognostic value of venous lactate with regard to in-hospital adverse outcomes and mortality in patients with pulmonary embolism (PE). The study involved 419 PE patients and it was found that an increased risk for adverse outcomes was associated with venous lactate above the upper limit of normal. Venous lactate cut-off value of 3.3 mmol/l predicted both, in-hospital adverse outcome and all-cause mortality and hence its levels could aid in risk stratification.
Danique E. Paping et.al. conducted a study to evaluate music listening habits through personal listening devices in adolescents with a smartphone application, and to assess the accuracy of self-reported listening habits. The researches concluded that self-reported measures of listening habits are not always accurate. We consider a smartphone application to monitor listening habits of added value in future research investigating the possible damaging effects of personal listening devices on hearing acuity.
Tansim Akhter et al. conducted a study to find whether asymmetric- and symmetric dimethylarginines (ADMA, SDMA) and l-arginine/ADMA and l-arginine/SDMA ratios during pregnancy and their changes from pregnancy to postpartum are correlated to arterial wall layer dimensions and cardiovascular risk factors in women with and without preeclampsia. The subjects with preeclampsia and healthy controls underwent an analysis of dimethylarginines and measurement of common carotid artery intima and media thicknesses which were reassessed one-year postpartum. Women with preeclampsia had higher plasma levels of dimethylarginines which were associated with adverse effects on arterial wall layer dimensions and cardiovascular risk factors.
Mary-Ann El Sharouni et.al. conducted a study to develop and validate a model predicting recurrences in patients with thin melanomas. The researchers concluded that most patients with thin melanomas have an excellent prognosis, but some develop recurrence. The presented nomograms can accurately identify a subgroup at high risk.
The prospective randomized study conducted by Veronika Röggla et al. aimed to assess the influence of artificial tears of different viscosity on K-readings prior to cataract surgery. The study involved 123 eyes that underwent baseline keratometries with subsequent instillation of either high- or low-viscosity eye drops followed by keratometry at 30 seconds, 2 minutes, and 5 minutes. There existed a measurement variability, especially in dry eyes, between baseline measurement and 30 seconds that diminished over time. It was also observed that the higher the viscosity of the eye drops, the stronger the influence and the longer its persistence. Based on the results of the study the authors recommend delaying keratometry for more than 5 minutes after instillation of eye drops.
Christopher Ryan Henry et al. conducted a prospective study to assess the local and systemic safety of suprachoroidal triamcinolone acetonide injectable suspension (CLS-TA) injections in patients with non-infectious uveitis. The study involved 38 patients who were administered 2 suprachoroidal injections of CLS-TA 4 mg, 12 weeks apart and subsequently underwent best-corrected visual acuity, adverse event assessment, ophthalmic examinations and OCT. It could be concluded from the results of the study that the injections were safe and well-tolerated.
Masahito Kawabori et al. conducted a 1-year double-blind, randomized, surgical sham-controlled, phase 2 trial to determine the safety and efficacy of intracranial implantation of allogeneic modified bone marrow-derived mesenchymal stromal/stem cells in patients with chronic motor deficits secondary to traumatic brain injury (TBI). The implantation was found to be safe and well-tolerated and a significant improvement from baseline motor status at 6 months was observed in the patients.