George E. Naoum et.al. conducted a study to independently evaluate the impact of axillary surgery type and regional lymph node radiation on breast cancer–related lymphedema rates in patients with breast cancer. The researchers concluded that although regional lymph node radiation adds to the risk of lymphedema, the main risk factor is the type of axillary surgery used.
Eve Maubec et.al. conducted a study to evaluate first-line pembrolizumab monotherapy efficacy and safety in patients with unresectable cutaneous squamous cell carcinomas. The researchers concluded first-line pembrolizumab monotherapy exhibited promising anti-CSCC activity, with durable responses and manageable safety.
Pieternella Johanna Lugtenburg et.al. conducted a study to assess whether rituximab intensification during the first 4 cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone could improve the outcome of these patients compared with standard rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. The researchers concluded that early rituximab intensification during rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone -14 does not improve outcome in patients with untreated diffuse large B-cell lymphoma.
Fabian Knörr et.al. conducted a study to analyze the efficacy of a risk-stratified treatment of children with relapsed anaplastic large cell lymphoma. The researchers concluded that shorter time to relapse was the strongest predictor of subsequent relapse. Allogeneic stem cell transplantation offers a chance for cure in patients with high-risk anaplastic large cell lymphoma relapse.
Loren K. Mell et.al. conducted a study to determine whether intensity modulated radiation therapy could lead to improved tolerance to concurrent cisplatin and gemcitabine for locoregionally advanced cervical cancer. The researchers concluded that intensity modulated radiation therapy can permit higher doses of concurrent gemcitabine with cisplatin and pelvic radiation for locoregionally advanced cervical cancer.
Elias K. Mai et.al. conducted a study to assess the efficacy of Bortezomib-based induction, high-dose melphalan and lenalidomide maintenance in myeloma up to 70 years of age. The researchers concluded that an intensive upfront therapy with a bortezomib-containing IT, high-dose melphalan/autologous blood stem cell transplantation, lenalidomide consolidation, and maintenance should be applied to transplant-eligible MM patients up to 70 years of age.
Celestia Fang et.al. conducted a study to understand the determinants and assess the role of chromatin organization in acute leukemia. The researchers concluded that cells that harbor mutations in these genes display aberrant chromatin architecture and resulting differences in gene expression that contribute to leukemia initiation and progression.
Avani Athauda et.al. conducted a study to assess the impact of sex and age on chemotherapy efficacy, toxicity and survival in localised oesophagogastric cancer. The researchers concluded that females had significantly improved survival while experiencing more gastrointestinal toxicities. Older patients achieved comparable survival to younger patients and thus, dependent on fitness, should be offered the same treatment paradigm.
David Cibula et.al. conducted a study to evaluate sentinel lymph node biopsy without pelvic lymph node dissection in patients with early-stage cervical cancer. The researchers concluded that sentinel lymph node biopsy can achieve high bilateral sentinel lymph node detection in patients with tumours of 4 cm or smaller. At experienced centres, all sentinel lymph node were found in the pelvis, and most were located below the iliac vessel bifurcation.
Julie Arsenault et.al. conducted a study to assess the acute toxicity and quality of life of hypofractionation compared with conventional fractionation for whole breast irradiation after breast-conserving surgery. The researchers concluded that Hypofractionated whole breast irradiation compared with conventional whole breast irradiation resulted in less acute toxicity and improved quality of life.