This study explored the association between livestock exposure and comorbid/concurrent conditions in patients with overlapping diagnoses of asthma and COPD. Livestock exposure is not associated with comorbid chronic conditions but appears to be a risk factor for symptomatic effects in patients with overlapping diagnoses of asthma and COPD.
The study aimed to assess the status of vitamin D for patients with pityriasis alba. 44 patient diagnosed with pityriasis alba were enrolled and the second group of 44 controls was involved in our study. Serum levels of circulating 25 (OH) D were measured. Study findings conclude none of the cases had sufficient serum level; the level ranged between 8.1-27.3 ng/ml. The patients had lower circulating vitamin D levels than controls.
This retrospective, longitudinal, and repeated-measures study assess vestibular aqueduct (VA) morphology and frequency-specific hearing thresholds with sex as the primary predictor of interest. Females seem to have greater enlargement of the vestibular aqueduct, this difference does not extend to hearing loss. Therefore, study results indicate that criteria for enlargement of the vestibular aqueduct (EVA) diagnoses may benefit from re-evaluation.
This study is to determine the safety and preliminary efficacy of selective combination targeted therapy for BRAF V600E–mutant metastatic colorectal cancer (mCRC) in the safety lead-in phase of the open-label, randomized, three-arm, phase III BEACON Colorectal Cancer trial. In the safety lead-in, the safety and tolerability of the encorafenib, binimetinib, and cetuximab regimen are manageable and acceptable for initiation of the randomized portion of the study. The observed efficacy is promising compared with available therapies and, if confirmed in the randomized portion of the trial, could establish this regimen as a new standard of care for previously treated BRAF V600E–mutant mCRC.
This study examined whether individuals undergoing total hip arthroplasty who are self-rated as “highly active”, demonstrated higher pre-operative activity levels than others. The positive correlation between subjective and objective measures of mobility increase our confidence in the latter as a valid indicator of the patient's preoperative activity level.
Indomethacin in combination with nasal desmopressin was compared with indomethacin alone in the management of renal colic. While there was significant pain reduction in both patients groups, pain reduction of NSAIDs (e.g. indomethacin) in renal colic, does not significantly improve when given in combination with desmopressin.
Marian Khalili, et al. characterized clinicopathologic factors and evaluated outcomes of en bloc Pancreaticoduodenectomy (PD) and right hemicolectomy (RH) for locally advanced right colon cancer (LARCC). Data demonstrated that en bloc PD and RH is rarely performed yet can be a potentially safe treatment option in patients with LARCC.
Barry J. Ruijter et al attempted to provide proof in this prospective cohort study involving 850 patients that accurate forecast of outcomes following cardiac arrest are enabled with early EEG. Study participants included consecutive, comatose survivors of cardiac arrest. Continuous EEG recordings began as quickly as possible and continued for up to five days. Data revealed that 46% had a good outcome. According to findings, EEG enables accurate forecast of poor outcome following cardiac arrest, with peak sensitivity within the first 24 hours. Continuous EEG patterns are at 12 hours after cardiac arrest correlated with excellent recovery.
Daniel Vail et al assessed the effect of lipid-lowering medications on diabetic retinopathy and diabetic complications requiring intervention. For this retrospective cohort analysis, they involved 269,782 subjects diagnosed with type 2 diabetes mellitus between 2008 and 2015. The authors discover coherent proof that patients on lipid-lowering drugs are less likely to create non-proliferative diabetic retinopathy, proliferative diabetic retinopathy, or diabetic macular edema, and modest proof that these patients are less likely to receive anti-VEGF injections, laser therapies, or vitrectomy. The research validates the findings of studies in relatively homogeneous populations using claim databases in East Asia to estimate an association between statin usage and retinopathy, replicating them in a large commercial claims database in a U.S. context.
Lucie de Léotoing et al examined 7,863 women who underwent a 2G procedure (7.2%), 39,935 women who underwent a 1G procedure, (36.3%), 38,923 women who underwent curettage (35.4%) and 23,163 women who underwent hysterectomy (21.1%) regarding success rates, complications and management costs for abnormal uterine bleeding (AUB). Outcomes revealed the highest failure rate with curettage. They noted the lowest failure rate with hysterectomy but with the highest complication rate and the highest expenses. Although 1G and 2G procedures had good clinical outcomes and relatively low cost, their wide use is not reported. Current guidelines recommending using 2G procedures for treatment of AUB, are not respected, its use is reported only in <10% of cases.