Ayah Qassem Shqair, et al. investigated the association between screen-time behavior and diet, including a potentially cariogenic diet, in children younger than 12 years old. They concluded that there may be an association between sedentary behavior, particularly television viewing, and an unhealthy diet in young people involving increased intake of cariogenic foods.
Researchers undertook a study to evaluate the histopathologic correlation of recently described subclassification of Bosniak category 3 cysts (3s and 3n). The subclassification of Bosniak 3 cysts as 3s and 3n was found helpful in differentiating highly suspicious malignant lesions from the relatively less suspicious ones.
Investigators tried to estimate the additive genetic, maternal, and environmental effects in ASD. Based on population data from 5 countries, the heritability of ASD was estimated to be approximately 80%, indicating that the variation in ASD occurrence in the population is mostly owing to inherited genetic influences, with no support for contribution from maternal effects.
Stephen Lam, et al.explored the associations between aerobic fitness, as determined objectively by preoperative cardiopulmonary exercise testing (CPEX), and 30-day morbidity after esophagectomy. They found that the exercise testing variables were not associated with 30-day complications after esophagectomy. The findings did not support the use of cardiopulmonary exercise testing as an isolated preoperative screening tool to predict short-term morbidity after esophagectomy.
Catherine Bédard, et al. carried out a study to validate the Ottawa 3DY-French (O3DY-F) Scale as a screening tool for delirium and cognitive impairment in a French-speaking cohort. The O3DY-F was found to be a useful and effective tool to screen for delirium and undetected cognitive impairment among a French-speaking cohort in the ED.
The objective of this study was to elucidate the mechanisms of the formation of severe and prolonged pressure ulcers (PUs) under the zinc deficiency condition. They assessed PUs formation after cutaneous ischemia-reperfusion (I/R) injury in mice fed with a zinc-adequate (ZA) or a zinc-deficient (ZD) diet from 2 weeks before I/R injury. Wound size, vascular damage, apoptotic cells, adenosine triphosphate (ATP) amount, and the number of Langerhans cells (LCs) in I/R area were analyzed. Also evaluated the extent of oxidative stress in I/R area in OKD48 mice through bioluminescence detection. Zinc deficiency might increase cutaneous I/R injury-induced vascular damages, oxidative stress, and apoptosis, as well as ATP amount in I/R area due to the loss of LCs.
In this single armed study with historical control they tested the hypothesis that before salvage surgery administration of immunonutrition would decrease complications in this high risk population of recurrent head and neck squamous cell carcinoma. In patients undergoing salvage surgery for recurrent head and neck squamous cell carcinoma, preoperative immunonutrition exhibited favorable effects on the complication rate and consequently reduced the length of hospital stay.
This randomized, multicenter controlled study is to compare the survival outcomes of neoadjuvant three-dimensional conformal radiotherapy (RT) followed by hepatectomy with hepatectomy alone in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT). For patients with resectable HCC and PVTT, neoadjuvant RT provided significantly better postoperative survival outcomes than surgery alone. IL-6 may predict response to RT in these patients.
In this multinational, phase 2, dose-finding study and extension study, they evaluated the safety and side-effect profile of vosoritide in children (5 to 14 years of age) with achondroplasia. A total of 35 children were enrolled in four sequential cohorts to receive vosoritide at a once-daily subcutaneous dose of 2.5 μg per Kg of body weight. In children with achondroplasia, once-daily subcutaneous administration of vosoritide was associated with a side-effect profile that appeared generally mild. Treatment resulted in a sustained increase in the annualized growth velocity for up to 42 months.
The aim of this study was to determine whether the SeptiFast® (SF) assay is applicable to the culturing of bronchoalveolar lavage (BAL) of children with pulmonary infections and whether the frequency of pathogen detection is enhanced by the use of this multiplex polymerase chain reaction (PCR) method. Compared to conventional culture, the use of the SF assay on the BAL of children with pneumonia increases pathogen detection rates and therefore adds important information to guide anti-infective therapy.