Research Desk

Jul 17, 2019

Tanja Luescher et al examined if the prognostic ability of two cardiac arrest-specific risk scores could be enhanced by measuring neuron-specific enolase (NSE) at different days after a cardiac arrest. The analysis revealed significant improvement in clinical risk scores for outcome prediction in cardiac arrest patients when measuring NSE at day 3; they recommend adding NSE measurement at day 3 to clinical decision making about escalation or withdrawal of therapy in this vulnerable patient population.

 

Jul 17, 2019

Pei-Yi Fan et al analyzed patients who underwent invasive gynecologic procedures in a tertiary medical center, to assess the clinical presentation, results, and impacts of prophylactic antibiotic use prior to invasive techniques. Overall 18 peritoneal dialysis patients who underwent 26 gynecologic procedures between 2005 and 2015 were included. Following invasive gynecologic procedures, 6 patients suffered 7 episodes of peritonitis. Prophylactic antibiotic treatment was administered prior to 11 procedures (6 oral cefadroxil, 1 oral cefuroxime, 1 oral clindamycin, 1 intravenous [IV] ceftriaxone, 1 IV ceftazidime, and 1 IV cefazolin). The identified pathogens were diverse and included group B Streptococcus, group D StreptococcusE. coli, and Enterococcus. As per findings, a considerable attenuation in the risk of peritonitis following invasive gynecologic procedures was achieved with prophylactic antibiotic treatment

Jul 17, 2019

Jung J.Y et al focused on the predictive ability of blood pressure (BP) for incident metabolic syndrome (MetS) among Koreans (n=5,809) without baseline MetS. The participants were categorized according to baseline systolic (SBP) and diastolic BP (DBP) and incident MetS was identified via monitoring for 10 years. To assess the HR and 95% CI for MetS by SBP and DBP, they used a Cox proportional hazards model. Including normotensive subjects, a subgroup analysis was carried out following a new guideline of the American College of Cardiology and the American Heart Association. According to the findings, the risk of incident MetS increased proportionally to baseline SBP and DBP. Even normotensive subjects showed this identically.

Jul 17, 2019

Kenneth W. Mahaffey et al explored its impacts on specific cardiovascular outcomes as well as in those without prior cardiovascular disease (primary prevention). Participants (n=4,401) were patients with type 2 diabetes and chronic kidney disease. In a random manner, these patients received canagliflozin or placebo with optimized standard of care. Relative to secondary prevention participants (N=2,220; 50.4%), the primary prevention participants (N=2181; 49.6%) had younger age, shorter diabetes duration, and were more often female. In patients with type 2 diabetes and chronic kidney disease, including those without prior cardiovascular disease, a significant reduction in major cardiovascular events and kidney failure was evident in relation to treatment with canagliflozin.

 

Jul 16, 2019

Alexander Faje et.al. conducted a study to risk of hypophysitis following treatment with nivolumab or pembrolizumab and also to specify the clinical presentation and outcomes in these patient. The researchers concluded that Hypophysitis occured rarely with these medications and those patients had a distinct phenotype compared to hypophysitis after treatment. 

Jul 16, 2019

Celiac disease (CD), a systemic, immune-mediated disorder triggered by gluten in genetically susceptible individuals. Francesco et.al. conducted a review to focus on Celiac disease in order to outline the contribution of gut paracellular permeability when it comes to disease pathogenesis. based on current evidence derived from available clinical trials of larazotide acetate. 

Jul 16, 2019

Andrew M. Youssef et.al. evaluated the use of MRI for specific processes like somatotopy of changes in the somatosensory system for different pain origins and the differences in the effects of CRPS upon the somatosensory system. The researchers concluded that pediatric and adult CRPS are differentially represented and thus there is a significant difference in  child and adult pain vulnerability and resilience.

Jul 16, 2019

Woolfson et.al. conducted a study to assess  clinical course, and risk factors, prevalence of Passenger lymphocyte syndrome in children following ABO-compatible liver transplantation and concluded that Passenger lymphocyte syndrome in such children showed 14% prevalence and recipient blood group A+ receiving a donor O+ graft was a major risk factor. 

Jul 16, 2019

Ashish Patel et.al. conductedba study to understand the distribution of blood pressure as well as the prevalence of hypertension and prehypertension among children and concluded that there was a very high prevalence of prehypertension and hypertension in Indore schoolchildren. 

Jul 12, 2019

This systematic review and meta-analysis included 5 case-control studies, 2 cross-sectional studies, and 1 cohort study with a total of 93 601 unique participants with hidradenitis suppurativa to investigate the association between hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD). These results suggest that participants with hidradenitis suppurativa who had 2.12-fold increased odds for Crohn disease and 1.51-fold increased odds for ulcerative colitis. One cohort study found a 5.6-fold increased risk of inflammatory bowel disease in patients with hidradenitis suppurativa.