Research Desk

Feb 19, 2019

Hyun Woo Goo studied the technical feasibility of semiautomatic 3-D threshold-based cardiac CT quantification of left ventricular mass in patients with various degrees of left ventricular hypertrophy in 99 patients. They concluded that CT quantification is feasible with high reproducibility and the mass values and the ventricular volumes can be used in patients with various degrees of LVH. 

Feb 19, 2019

A study aimed to report root coverage outcomes in single deep gingival recessions (GR) following a proposed decision-making algorithm. Following the proposed decision-making algorithm, root coverage outcomes for GR defects ≥5 mm were comparable to outcomes reported for shallow defects. The proposed algorithm allows the clinician to select the appropriate surgical technique for treatment of single deep gingival recessions with good predictability.

Feb 19, 2019

Researchers attempted to introduce a new protocol for patients with primary nocturnal enuresis to increase efficacy of treatment and decrease relapse rate. 185 children aged >5 years, with monosymptomatic enuresis or non-monosymptomatic enuresis, strictly abided by the protocol, and followed-up >24 months. They found that adopting combination therapy along with structured withdrawal as per their protocol showed higher success rates and lower relapses in primary nocturnal enuretic children.

Feb 13, 2019

Bo‐Lin Ho et al assessed the safety and persistence of dabigatran after co-medication with statins. Participants in the study were stroke patients with nonvalvular atrial fibrillation (NVAF) who started dabigatran therapy within 3 months after a clinically evident ischemic cerebrovascular event between 2013 and 2017. A total of 652 patients followed dabigatran therapy for one year. According to findings, co-prescription with a statin was related to a lower risk of bleeding complications for secondary prevention of stroke in patients with NVAF who were taking dabigatran etexilate [a direct thrombin inhibitor that clinicians increasingly prescribe to prevent stroke in patients with NVAF].

Feb 13, 2019

Claudia Becker et al analyzed the risk of cataract in relation to exposure to ACE inhibitors (ACEIs) and other antihypertensive drugs between 1995 and 2015. They evaluated a number of prescriptions for ACEI and other antihypertensive drugs in detail and explored the use of single ACEI substances. A total of 206,931 cataract cases and the same number of matched controls were recognized. They concluded that the use of ACEI was not correlated with a materially modified risk of cataract as compared to non-use of ACEI. 

Feb 13, 2019

Silvia Dellapasqua, MD et al sought to determine the endocrine activity in terms of ovarian function suppression (OFS) of degarelix (a gonadotropin-releasing hormone [GnRH] antagonist) vs triptorelin (a GnRH agonist) in premenopausal patients receiving letrozole as neoadjuvant endocrine therapy for breast cancer. Findings suggested that premenopausal women who received letrozole for neoadjuvant endocrine therapy achieved OFS more quickly. This was maintained more effectively with degarelix than with triptorelin.

 

Feb 13, 2019

Andrea Vecchiola et al investigated the association of aldosterone, renin or the plasma aldosterone/renin ratio (ARR) with metabolic disorders and inflammatory/vascular biomarkers. Findings revealed the correlation of ARR with the number of variables of MetS, BMI, SBP, DBP, potassium excreted fraction, LDL, PAI-1, microalbuminuria, and leptin. Overall, a continuum of cardiometabolic risk beyond the classic PA threshold screening was suggested. Compared to aldosterone or renin alone, ARR could serve as a more sensitive marker of obesity, MetS and endothelial damage in non-PA patients.

 

Feb 13, 2019

Davide Zattoni MD et al studied the utility of the Flemish version of the Triage Risk Screening Tool (fTRST) to assess precisely, the frailty in an emergency setting. They recorded more than twice the average length of hospital stay as long in the group with an fTRST score of 2 or greater (15.2 days) as compared to those with a score less than 2. Hence, they preferred fTRST as an effective tool to predict the postoperative course, to determine care goals, and also to plan for involvement of a dedicated geriatric care team.

Feb 13, 2019

This study examined early perioperative complications and subsidence following total hip arthroplasty (THA) with a short femoral stem. A retrospective review of 207 consecutive patients (247 hips) having undergone THA via the direct anterior approach produced only six perioperative complications. Cementless THA with a direct anterior approach with a short femoral stem provides a clinical and radiographic advantage while maintaining low complication rates.

Feb 13, 2019

In a double-blind trial, they randomly assigned adults with community-acquired bacterial pneumonia to receive omadacycline or moxifloxacin. Results suggest omadacycline was noninferior to moxifloxacin for the treatment of community-acquired bacterial pneumonia in adults.