J.Y. Reginster et al estimated the relative effectiveness of abaloparatide vs other therapies to reduce the risk of fractures in women with postmenopausal osteoporosis (PMO). In all, abaloparatide exhibited the greatest treatment effect relative to placebo in the vertebral fracture (VF) network, the nonvertebral (NVF) network, and the wrist fracture network vs other treatments. Compared with other treatments, abaloparatide had the greatest estimated possibility to prevent the fractures in the following networks: 79% for VF, 70% for NVF, and 53% for wrist fracture
Angela Guarino et al assessed executive functions (EFs) in patients with mild cognitive impairment (MCI), specifically inhibition (motor and cognitive), conflict control and cognitive flexibility. For this review, eligibility criteria were use of specific paradigms for EFs assessment (“Wisconsin Card Sorting Test,” “Stroop Task,” “Go/No-Go Task,” “Flanker Task”), age over 65, and studies published in English. The four experimental tasks studied were supported as being applicable and are identified as being valuable for research, diagnosis and therapeutic needs that may help to determine the EFs profile that can impact daily life in the elderly. Standard assessment of MCI generally does not determine EFs. However, EF evaluation may enhance MCI knowledge and aid in diagnosis and treatment
Eu Jeong Ku et al assessed the efficacy and safety of two distinct sodium-glucose cotransporter 2 (SGLT2) inhibitors, empagliflozin vs dapagliflozin, as part of a quadruple oral antidiabetic agents (OADs) regimen. This investigation was conducted in T2D subjects with glycated hemoglobin (HbA1c) from 7.5-12.0% with metformin, glimepiride, and dipeptidyl peptidase-4 inhibitors. For this open-labeled, prospective, 52-week study, patients received either empagliflozin (25 mg/day) or dapagliflozin (10 mg/day). In T2D patients who are treated with three other OADs, SGLT2 inhibitors could be effectively used as a fourth OAD. More specifically, in reducing HbA1c and improving other cardiometabolic parameters, empagliflozin was more effective than dapagliflozin.
Jonneke S. Kuperus et.al. studied the early phase of DISH by using CT data from two large-scale retrospective cohorts, each with 5-year follow-up. They concluded that early DISH criteria had high sensitivity and specificity for predicting the development of DISH.
Sandro J. Corti et.al. studied and compared the injury characteristics, symptoms, and neurologic examination in sport-related concussion based on age. They concluded that the pediatric age group had a higher average of the number of sleep hours, although the initial presentation does not differ according to the age especially within 7 days of injury.
Tilman Perrin et.al. studied the rate of inappropriate ventricular arrhythmia diagnoses and therapies in patients followed by remote monitoring along with the delay in next patient contact. They concluded that 9% of patients implanted with an ICD during the first 14 months showed inappropriate diagnosis.
Yamina Dassa et.al. studied the prevalence of permanent pituitary hormone deficiency and to detect the emergence of other pituitary dysfunctions or central precocious puberty after a long time of childhood traumatic brain injury. They concluded that severe brain injury in childhood can lead to permanent pituitary dysfunction; GH deficiency and Central precocious puberty may appear after many years.
Jooste, Valérie et.al. tried to understand the various causes of death in patients diagnosed with colon cancer between 1990 and 2010 in France. They concluded that crude probability of death related to colon cancer is an important indicator for patients and health policy makers.
A team of researchers headed by Thorhildur Halldorsdottir examined the association of polygenic risk scores (PRSs) for a broad depression phenotype derived from a large-scale genome-wide association study (GWAS) in adults and its interaction with childhood abuse. Evidence was found for an additive, but not an interactive, effect of the depression PRS and childhood abuse on depression outcomes.
Research revealed that in patients without HCV infection who received a heart or lung transplant from donors with hepatitis C viremia, treatment with an antiviral regimen for 4 weeks, initiated within a few hours after transplantation, prevented the establishment of HCV infection.