Research Desk

Jul 12, 2019

This is a randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of nintedanib in patients with ILD associated with systemic sclerosis. A total of 576 patients received at least one dose of nintedanib or placebo; 51.9% had diffuse cutaneous systemic sclerosis, and 48.4% were receiving mycophenolate at baseline. Among patients with ILD associated with systemic sclerosis, the annual rate of decline in forced vital capacity (FVC) was lower with nintedanib than with placebo; no clinical benefit of nintedanib was observed for other manifestations of systemic sclerosis.

 

Jul 12, 2019

The aim with this review is to discuss the clinical presentation, radiology, endoscopy, histopathology, and treatment algorithm of three different phenotypes of primary chronic rhinosinusitis (CRS): central compartment atopic disease, eosinophilic CRS, and non-eosinophilic CRS. A narrative review of a tertiary rhinology center’s research themes and how they are applied to clinical protocols and practice were assessed.

Jul 12, 2019

The CLARITY is a phase II trial that combined ibrutinib with venetoclax in patients with relapsed or refractory chronic lymphocytic leukemia (CLL). The primary endpoint was the eradication of MRD after 12 months of combined therapy. The combination of ibrutinib plus venetoclax was well tolerated in patients with relapsed or refractory CLL. There was a high rate of MRD eradication that led to the cessation of therapy in some patients.

Jul 12, 2019

In this study, the researchers aimed to determine whether the rs199772854A site mutation causes abnormal expression of the interleukin 17 receptor C (IL17RC) in Han Chinese patients with thoracic ossification of the posterior longitudinal ligament (T-OPLL) and predict the possible pathogenic mechanisms of T-OPLL. Analyses were performed to determine whether IL17RC is involved in the pathogenicity of T-OPLL. The results suggest that the IL17RC gene rs199772854A site polymorphism is a potential pathogenic mutation in T-OPLL disease, which may be associated with the occurrence of T-OPLL.

Jul 12, 2019

Oliver M. Theusinger, et al. evaluated a modified treatment algorithm (MTAS-EMS) using diazepam and midazolam due to a supply bottleneck of iv lorazepam in 2012. The treatment success of the MTAS-EMS was high. However, in adults the single dose of i.v. diazepam was as successful as the completely used MTAS-EMS and seemed to be superior to the single dose iv and nasal midazolam.

Jul 12, 2019

Researchers explored the associations between aerobic fitness, as determined objectively by preoperative cardiopulmonary exercise testing (CPEX), and 30-day morbidity after esophagectomy. Their findings concluded that preoperative CPEX variables were not associated with 30-day complications after esophagectomy.

Jul 11, 2019

Ki-Woong Nam et al assessed the connection between triglycerides (TG)/high-density lipoprotein (HDL) cholesterol ratio and the presence of silent brain infarct (SBI) SBI was defined as an asymptomatic, well-defined lesion with a diameter of ≥3 mm on T1- or T2-weighted images. From January 2006 to December 2013, the authors retrospectively assessed consecutive participants in health check-ups. Of al the participants, 8.3% had SBI lesions. The TG/HDL cholesterol ratio was positively correlated in the analyses of the links between lipid parameters and SBI lesion burden, and total cholesterol/TG ratio was negatively related to SBI lesion burden in dose-response manners. In a neurologically healthy population, the TG/HDL cholesterol ratio was positively linked to the prevalence of SBI. In males, this association was prominent, but not in females.

 

 

Jul 11, 2019

Ditte B. Jakobsen et al aspired to explore whether retinal vascular oxygen saturation and calibres could predict the initial treatment response after a loading phase of intravitreal aflibercept in neovascular age-related macular degeneration (nAMD). Of these, 57 treatment-naïve eyes with nAMD got three monthly injections with 2.0 mg aflibercept and subsequently stratified according to functional and structural reaction to best-corrected visual acuity and macular retinal thickness development. Investigators found that nAMD and dry AMD patients had higher retinal arteriolar oxygen saturation than normal eyes. Findings suggested that changes in retinal venular oxygen saturation are independently associated with initial treatment response in nAMD, but pre-treatment functional and structural retinal measurements could not predict the response of the treatment.

Jul 11, 2019

Sarah E. Tevis MD et al examined outcomes of patients undergoing single vs multi-site surgery in a large national surgical database in order to assess how the addition of a gynecologic and/or plastic reconstructive procedure to breast surgery influence the risk of postoperative complications and re-admissions. The analysis revealed a significantly longer length of stay, higher complication, readmission, and reoperation rates among patients undergoing coordinated procedures vs those who underwent single-site surgery. In addition, greater postoperative complications were reported among patients with surgery for breast cancer, either with a plastic or gynecologic procedure. Delays in adjuvant therapy may occur in correlation to higher complication rates for those with coordinated operationsHence recommendations for discussions regarding the indications for simultaneous surgery are made.

Jul 11, 2019

Ju Young Kim et al conducted a population-based cohort study to investigate the impact of oral diabetes medication on the risk of dementia in the elderly. Participants in the study included subjects aged 60 years or older with and without type 2 diabetes. New-onset type 2 diabetes patients were further divided into oral diabetes medication and no-medication groups. The three-drug combination of sulfonylurea, metformin, and DPP4 inhibitor was associated with a 63% reduced dementia risk vs the sulfonylurea monotherapy group. Overall, in elderly patients with type 2 diabetes, the use of oral diabetes medication significantly reduced the risk of dementia.