James D. Heaton, et al. aimed to determine the safety of a 2-hour observation period for heroin overdose patients who receive naloxone. They concluded that a 2-h ED observation period for heroin overdose patients reversed with naloxone resulted in a delayed intervention rate of 5%. Clinicians may consider a 3-h observation period, with extra scrutiny in polysubstance abuse.
The influence of patient- and implant-related factors on implant stability and the 5-year implant survival and the influence of stability (ISQ value) at placement and abutment connection on implant survival was investigated. A significantly higher risk for implant failure, showing an ISQ value below 70 and 75 at placement or after 3-4 months of healing was found. The results indicate that resonance frequency analysis (RFA) measurements can be used to identify implants with increased risk for failure.
A. Petrikovets and a team of researchers aimed to evaluate whether voiding parameters differ in patients with the common overlapping pelvic pain disorders, interstitial cystitis/bladder pain syndrome (IC/BPS), and myofascial pelvic pain (MPP). Patients with IC/BPS had more pain with a full bladder despite similar overall pain scores. Peak and average flow rates do not provide any differentiating power between IC/BPS and MPP patients.
In this study, they implemented melanocytes in a tissue-cultured full-thickness skin equivalent, consisting of epidermis and dermis. The versatility of this skin-like model with respect to pigmentation and morphological criteria was tested. This study demonstrates that the herein-introduced organotypic tissue-cultured skin equivalent is comparable to the normal human skin and its versatility in tests regarding skin pigmentation. Therefore, this model might help understand diseases with dysfunctional pigmentation such as melasma, vitiligo, and postinflammatory hyperpigmentation.
This retrospective study was performed of patients who had a category I or III FNA result and underwent rFNA of the same thyroid nodule between 2013 and 2015. A total of 237 patients (474 thyroid FNAs) were included. Result suggest rFNA for category I and III nodules provided a definitive diagnosis in only 40% of cases, which is important for patient counseling.
This study was to assess the detection accuracy of sentinel lymph node (SLN) metastasis by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) for endometrial cancer (EC). Study results demonstrated that qRT-PCR assay, using CK19 mRNA, exhibits a high accuracy for detecting LN metastasis in EC and represents a useful alternative to conventional pathological diagnosis of EC.
This was a non-interventional, prospective study to assess the impact of omalizumab treatment in obese asthmatic patients with poorly controlled severe persistent asthma. The study showed that omalizumab significantly improved asthma control, reduced rescue medication and asthma exacerbations in all the population; and for the first time showed that obese patients achieved significantly improved lung function.
The aim of this study was to evaluate the efficacy and safety of aspirin prophylaxis when compared with placebo or anticoagulants in this population of patients. Among patients who underwent knee or hip arthroplasty, aspirin prophylaxis was found to be associated with similar efficacy and safety outcomes when compared with anticoagulants. When compared with placebo, aspirin prophylaxis was associated with significantly reduced VTE and a comparable safety profile.
The authors focused on the features and the clinical correlates of dizziness, as well as on its prognostic significance for all-cause, cardiovascular, and stroke mortality. Participants included 1716 individuals from the OLD-HTA Lyon's cohort of hypertensive patients. These subjects were divided based on the absence or the presence of dizziness. Further subdivision of the dizziness group into vertigo and other dizziness excluding vertigo was done. By multivariate Cox regression model, the risk for all-cause mortality, cardiovascular mortality, or stroke mortality was not influenced by the presence of dizziness. A prognostic effect was shown by only vertigo in an analysis of the different subgroups of dizziness. Overall, a high-risk profile at baseline was absent in hypertensive patients with dizziness, but higher stroke mortality observed in those with vertigo makes it necessary to carefully follow these subjects over the years.
Sasha A. Mansukhani et al examined the incidence, demographics, and ocular characteristics of children with myasthenia (n=364). They noted 0.12 and 0.23 per 100 000, the incidence of juvenile myasthenia gravis (JMG) and congenital myasthenic syndrome (CMS), respectively. They observed 217 kids with juvenile myasthenia gravis (JMG), 141 with the congenital myasthenic syndrome (CMS), whereas 1.7% of cases had Lambert-Eaton syndrome, diagnosed at a median age of 13.5, 5.1, and 12.6 years, respectively. They noted ocular involvement like ptosis and ocular movement deficits among most of the JMG and CMS subjects, ie, 90.3% and 85.1%, respectively. They recorded the improvement in 88.8% of JMG cases (complete remission in 31.3%) and 58.3% of candidates with CMS among children with at least 1 year of follow-up (JMG; median, 7.1 years, CMS; median, 7.0 years).