Research Desk

Jul 11, 2019

Adam M. Staffaroni et al ascertained if an atrophy-based risk score could be developed to anticipate the onset of dementia. Dementia risk scores were created in 268 familial frontotemporal lobar degeneration family members by entering covariate-adjusted standardized estimates of brain atrophy into a logistic regression to classify asymptomatic vs demented candidates. Good separation of asymptomatic vs demented patients was accomplished by cross-validated logistic regression. Atrophy scores forecast conversion to dementia from asymptomatic or mildly/questionably symptomatic. With 90% accuracy, quantification of the unique atrophy pattern of each individual can separate those with dementia from those without symptoms. A promising predictor of progression in asymptomatic familial frontotemporal lobar degeneration mutation carriers is the individualized quantification of baseline brain atrophy.

 

Jul 11, 2019

Researchers undertook a study to discover and functionally evaluate genetic loci for schizophrenia in a GWAS of a unique Indian population. They found that bioinformatic analyses and cellular and zebrafish gene expression studies implicate NAPRT1 as a novel susceptibility gene. 

Jul 10, 2019

M. Francesca Monn, et al. conducting a study to evaluate the feasibility and outcomes of full-thickness penile skin grafting (FTSG) for phalloplasty during acquired buried penis repair. They concluded that full thickness skin grafts provide a useful option for penile reconstruction during surgical management of buried penis.

Jul 09, 2019

Diana Micleaa et.al. conducted a study to use single nucleotide polymorphism array technology in order to determine the copy number variant type and frequency associated with both obesity and developmental disability/intellectual disability. The researchers concluded that some of these copy number variants have already been observed in patients with both obesity as well as developmental disability/intellectual disability.

Jul 09, 2019

Zhi-Yong Li et.al. conducted a study to compare LNM and prognosis between diffuse and intestinal-type early gastric cancer EGCs using comprehensive statistical analysis. The researchers concluded that diffuse-type EGC can have a varying risk of lymph node metastasis and prognosis in comparison to intestinal-type EGC. 

Jul 09, 2019

Akshya Gupta et.al. conducted a study to determine the rate of missed CT findings of ileal carcinoid tumor prior to pathologic diagnosis and the resultant diagnostic delay. The researchers concluded that the initial presentation of ileal carcinoid tumor is often missed prospectively at abdominal CT and thus it leads to a delay in diagnosis until the bowel or the mesenteric findings become obvious. 

Jul 09, 2019

Amarachi Ejiawoko et.al. conducted a study to identify hospital variation in home oxygen use, predictors of home oxygen use in preterm infants who are a known case of bronchopulmonary dysplasia and concluded that home oxgyen use varies across California and community centers were found to be having a shorter length of stay. 

Jul 09, 2019

Anders W Bjerring et.al. conducted a study to improve the understanding of the effects of endurance training on the developing heart and concluded that athletes with continual endurance training endurance developed eccentric changes with chamber dilatation and little change in wall thickness.

Jul 05, 2019

This study is to analyze the Physician Global Assessment (PGA) using data from studies of tofacitinib in moderate to severe chronic plaque psoriasis. Confirmatory Factor Analyses showed that equal weighting of the three items (erythema, induration, and scaling) was appropriate. The PGA demonstrated acceptable test-retest reliability and internal consistency. These results indicate that this PGA is a valid, reliable instrument for evaluating disease severity in clinical studies of psoriasis.

Jul 05, 2019

Researchers performed a microbial genome-wide association study (mGWAS) to investigate whether S. aureus isolates from CRS patients have particular genetic markers associated with CRS with nasal polyps (CRSwNP) or CRS without nasal polyps (CRSsNP). Study results suggest that CRS phenotype may be influenced by genetic factors other than specific virulence mechanisms within the S. aureus genome.