In this, they evaluate whether the serum concentration of HGF can be used as a biomarker for the clinical response to anti-PD-1 antibody therapy. This study included 29 metastatic melanoma patients receiving nivolumab or pembrolizumab. Results suggested that c-MET inhibition promotes perforin expression in CD8+ T cells. Therefore, c-MET inhibitors can activate the immune system and may play an important role in combined immunotherapy.
The objective of this trial was to test the efficacy of trans-tympanic injections of sodium thiosulfate (STS) gel to prevent cisplatin-induced ototoxicity. This trial suggests that STS deposited on the round window was safe for the middle and inner ears.
This is a retrospective review of pure (nine patients) and mixed (18 patients) ductal adenocarcinoma of the prostate. This series demonstrates the atypical presentation and unusual clinical behavior of ductal adenocarcinoma and proposes management guidelines to assist clinicians. This series shows the atypical clinical presentation of this entity, as well as its propensity to metastasize to unusual sites. Relapse may occur at low absolute PSA values and is often asymptomatic.
This study is to analyze the genetic polymorphism to predict methotrexate efficacy in Chinese patients with psoriasis vulgaris. They used the whole exon high-throughput sequencing technology to detect the DNA sequence of 22 psoriasis vulgaris patients (11 responders, 11 non-responders) treated with methotrexate. They found 3 new SNPs that could predict the efficacy of methotrexate in psoriasis vulgaris to some extent, providing a theoretical basis for precision medicine of methotrexate in the future.
This is a retrospective study aimed to review cases of oral cancers & its treatment during pregnancy. They reviewed 1109 patients with oral cancers; four (0.4%) had tongue carcinomas during pregnancy. In conclusion, in addition to tumor factors, the wishes of the patient and her family, gestational age, and fetal and maternal conditions are important factors in deciding on a treatment protocol. Moreover, treatment decisions require a multidisciplinary approach.
In this study, they investigated how donor clonal hematopoiesis of indeterminate potential (CHIP) affects the outcome of allogeneic hematopoietic stem-cell transplantation (HSCT). They concluded that allogeneic HSCT from donors with CHIP seems safe and results in similar survival in the setting of older, related donors.
In this case-control study, they compare the clinical outcomes of one-stage and two-stage procedures for the management of patients with rotator cuff tear and concomitant shoulder stiffness. In the treatment of rotator cuff tear with concomitant stiffness, although the recovery of ROM took longer in patients who underwent the one-stage procedure, satisfactory results at final follow-up can be achieved using either the one-stage procedure or two-stage procedure.
The purpose of this cross-sectional study was to evaluate changes in lung parenchyma through computed tomography (CT) densitometry and, secondarily, to analyze its correlation with pulmonary function testing (PFT) in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD). Patients with NTM-PD show reduced lung mass and increased lung mass in the apical and basal regions of the lungs, respectively.
Roseanne D. Dobkin et al examined how cognitive-behavioral therapy (CBT) affects different types of depressive symptoms in Parkinson's disease (PD). They investigated if the strongest effect would be seen in cognitive (eg, guilt, rumination, negative attitudes towards self) and behavioral (eg, avoidance, procrastination) symptoms targeted most intensively by the treatment protocol. Outcomes suggest that a wide range of depressive symptoms in PD could be improved with CBT. The largest change was noted in cognitive and behavioral (vs somatic) symptoms. A combination of CBT and antidepressants was valuable in optimizing the management of somatic complaints in dPD.
Alessandro Marchese et al studied 26 eyes of 13 candidates from January 2016 to April 2018, to identify the role of vitreous involvement in vitreoretinal lymphoma (VRL) with the aid of multimodal imaging including ultrawide-field imaging and slit-lamp photography. They observed the presence of vitreous haze (3 patterns) in 92% of total eyes. They found linear opacities with a myriad of cells aligned along the vitreous fibrils. An aurora borealis pattern was noticed in 12 eyes. They recorded a string of pearls pattern in 2 eyes at baseline which developed in other 4 eyes after vitrectomy, exhibiting fine fibrils (connecting the bunches of inflammatory material).