Claude S. Farah et al assessed changes in ventilation inhomogeneity, a marker of small airway function, post-commencement of mepolizumab. They determined global (Lung Clearance Index, [LCI]) and regional ventilation inhomogeneity in acinar (Sacin) and conducting (Scond) airways, at baseline, Week 4 and Week 26, by using the Asthma Control Questionnaire (ACQ-5), spirometry, fraction of exhaled nitric oxide (FeNO) and multiple breath nitrogen washout. There was a correlation between change in ACQ-5 and change in Sacin and FRC, but not with spirometry changes. Overall, mepolizumab commencement resulted in rapidly improved symptom control. An association was observed between early improvement in small airway function and asthma control. The early improvement in small airway function could be a significant contributor to the therapeutic response.
Jennifer A. Woyach, M.D., et al conducted a phase 3 trial to evaluate the efficacy of ibrutinib, either alone or in combination with rituximab, relative to chemoimmunotherapy. Among older patients with untreated CLL, treatment with ibrutinib was superior to treatment with bendamustine plus rituximab with regard to progression-free survival. There was no significant difference between ibrutinib and ibrutinib plus rituximab with regard to progression-free survival.
A study was conducted to assess the lung function in children born preterm, early nutrition care post discharge. The researchers followed up 281 such children for 6-years and concluded that lung function in such children may improve when they are fed a protein enriched diet post discharge during early life.
A study was conducted to assess Serum Uric Acid associated single neuclotide polymorphisms and their association with Cardiovascular disease risk and also other metabolic syndromes. The researchers concluded that there was independent association between SUA and Cardiovascular disease risk, metabolic syndromes and decreased eGFR in Mexican Population.
Researchers of a study explored intra and inter network resting state functional connectivity changes underlying the neurobehavioural symptoms in Thyrotoxicosis in 28 newly diagnosed cases and 28 healthy controls. They concluded that patient's with Thyrotoxicosis showed decreased functional connectivity and decline in cognitive function, mental balance as well as neuropsychological tests.
Kapil Sahnan et.al. studied definitive core outcome set for perianal Crohn’s disease as lack of outcomes hampers analysis of data while assessing treatment outcomes. They concluded that application of core outcome set reduced the heterogeneity in outcome reporting and thus helped in meaningful comparisons between mode of treatments, patient care etc.
Yiming Gao et.al. have reviewed normal pattern of nipple enhancement at MRI in healthy individuals with respect to its appearance in healthy individuals and co-related the normal nipple enhancement at MRI with structural anatomy of the nipple at histopathologic analysis, and artifacts and pitfalls related to MRI. As this helps Radiologists to differentiate between normal and abnormal nipple findings thereby providing increased diagnostic efficacy.
A study aimed at evaluating the hybrid reinforcement effects of zirconium oxide nanoparticles (nano-ZrO2) and glass fibers (GFs) at different ratios on the flexural and impact strengths of a polymethylmethacrylate (PMMA) denture base, found that flexural and impact strengths of PMMA-nano-ZrO2 + GF composites were significantly improved when compared with those of pure PMMA.
A study assessed the functional query outcome of patients with cystoscopic recurrence of stricture post-urethroplasty and evaluated the role of cystoscopy as an initial screening tool to predict future failure. It concluded that many patients with cystoscopic recurrence do not need an intervention after initial urethroplasty.
Researchers evaluated the effects of the interaction between child maltreatment (CM) and single nucleotide polymorphisms (SNPs) on the development of mental disorders (MD) and psychopathology. After Bonferroni multiple comparison correction, they did not find any statistically significant association of G × CM with either MD or psychopathology.