Jin-Wen TIAN et.al. conducted a study to determine the efficacy of a new method for opening culprit vessels to treat STEMI: intracoronary arterial retrograde thrombolysis (ICART) with PCI. The researchers concluded that ICART may be a breakthrough in the treatment of acute STEMI.
Shelley Valle et.al. conducted a study to investigate GnRH-mediated changes in HPG axis activity and gonadal development in response to energy availability in a wild bird. The researchers concluded that food restriction did not affect plasma luteinizing hormone but but it enhanced the plasma LH response to an injection of the glutamatergic agonist.
In this study, they tested the ability of Neosalus® foam to penetrate into the viable epidermis and in addition assessed its antibacterial properties. The ability of components of Neosalus® to be taken up into the viable epidermis and potentially made available for incorporation into the barrier lipids, combined with antibacterial properties, indicate that this formulation may be valuable not only in chronic hand dermatitis but also in various other forms of dermatitis.
Ansaar T. Rai et al sought to assess trends in length of stay, discharge status, and costs via the Mann-Kendall trend test. Using a retrospective observational study design, the Premier Healthcare Database was used to identify 505,824 patients with acute ischemic stroke, 11,811 of whom were treated with ET. There was a substantial rise in home discharge and a substantial decline in mortality among patients receiving ET. A significant decline in the length of stay was noted from 11.7 days to 8.7 days. Data reported that total index admission costs declined ≈17% from 2011 to 2017 ($50,516.5–$42,026.9). Overall, the authors concluded that clinical and economic indicators improved significantly between 2011 and 2017 for patients with acute ischemic stroke undergoing ET.
Sonja G. Karst et al investigated the prevalence of central retinal atrophy in patients being treated in a clinical setting for diabetic macular edema (DME). The study sample consisted of patients with DME, concentrating on those who developed central retinal thinning after DME treatment at the Department of Ophthalmology, Medical University Vienna. Using linear regression models and ANCOVAS, the relationship between visual acuity and ocular, systemic or DME treatment factors was calculated. A total of 1,437 patients with diabetes were analyzed for 6,684 outpatient visits. During the observation period, only 4% of patients treated for DME developed central retinal thinning. On average, when they first presented with DME compared to the overall DME cohort, the atrophy patients had higher CST and lower best-corrected visual acuity and received a combination of intravitreal injections and laser for DME treatment. Central retinal atrophy could not be attributed to excessive use of anti-VEGF or other DME therapy alone intravitreally applied.
Ilana B. Richman, MD et al reported the adoption of digital breast tomosynthesis (DBT, a fresh technology that could have a lower recall rate and a higher cancer detection rate than 2-dimensional mammography) for breast cancer screening in a large privately insured population, identified regional patterns of adoption, and recognized regional-level features associated with that adoption as compared to digital mammography (widely used technique for breast cancer screening but with an imperfect sensitivity and specificity). In comparison to 2-dimensional mammography, the use of DBT had some major trade-offs like more expensive costs and greater radiation doses with some machines. Moreover, most studies of DBT were retrospective and could not assess its long-term health results. However, the US Preventive Services Task Force and the American Cancer Society had not explicitly legalized DBT for routine breast cancer screening by indicating insufficient evidence, it is recommended by the American College of Radiology.
J Jendle MD, PhD et al examined treatment satisfaction with semaglutide vs placebo/active comparators in the SUSTAIN clinical trial program. In SUSTAIN 2–5 and 7, the Diabetes Treatment Satisfaction Questionnaire was utilized to assess patient-perceived treatment satisfaction, hyperglycemia, and hypoglycemia. Findings suggested an association of semaglutide with significantly greater (SUSTAIN 2–5) or comparable (SUSTAIN 7) improvements in overall treatment satisfaction vs comparators/placebo. Improvements in overall therapy satisfaction were generally higher in patients achieving vs not achieving treatment targets. No differences were noted between treatments for perceived hypoglycemia
J Jendle MD, PhD et al assessed cardiomyopathy in patients with T2DM who live with or without cardiovascular complications by estimating different cardiac biomarkers. To assess the significant association between cardiac biomarkers other biochemical parameters, Pearson's correlation analysis was performed. The positive relationship was found between HbA1c and calcium or BNP levels; however, a negative connection was noted with zinc level. BNP and calcium levels were significantly increased in T2DM patients with cardiovascular complication, while zinc was significantly reduced. In addition, a positive correlation was found between BNP, calcium, Troponin-I levels, and blood pressure. However, to verify these results, further longitudinal studies are required.
The aim of this study was to use of bone scintigraphy with single photon emission computed tomography (bone SPECT/CT) in the assessment of low back pain in elderly patients with degenerative lumbar spine disease, underlining the clinical utility of bone SPECT/CT imaging in this clinical population to inform diagnosis and treatment. Bone SPECT/CT was useful to identify the specific cause of pain in elderly patients with a lumbar degenerative disease and to provide appropriate treatment, avoiding the unnecessary use of invasive spinal fusion surgery. Therefore, the clinical utility of bone SPECT/CT is potentially high as it improves diagnosis and lowers the risk of inappropriate invasive spinal surgery.
In this study, they evaluated the effectiveness of Pirfenidone and Nintedanib in a population of idiopathic pulmonary fibrosis (IPF) patients diagnosed in the last 12 months at Florence Interstitial Lung Disease (ILD) Referral Centre. This study emphasizes that both antifibrotic drugs appeared to be a good therapeutic choice in terms of functional stabilization, also in older patients.