Sushmita Gordhandas et al reviewed the literature on hormone replacement therapy (HRT) in BRCA mutation carriers undergoing risk-reducing salpingo-oophorectomy (RRSO), including effects on quality of life, and cardiovascular, bone, and brain health. Findings revealed improved endocrine symptoms and sexual function after premature surgical menopause using HRT. Estrogen replacement therapy after oophorectomy led to no alteration in breast cancer risk in BRCA mutation carriers.
Hong Jiang et al assessed the association of dietary vitamin and carotenoid intake with age-related cataract (ARC) risk. A significantly decreased risk of ARC was reported in relation to higher consumption of certain vitamins and carotenoids in cohort studies, but evidence obtained from RCTs was not as clear.
Kai‐Pi Cheng et al studied the effect of Helicobacter pylori infection status and its eradication on glycemic control and antidiabetic therapy among patients with type 2 diabetes. According to findings, diabetic patients with active H. pylori infection need a higher intensity of glycemic treatment to achieve comparable glycemia. In addition, the eradication of H. pylori reduces A1C and, thus, improves glycemic control.
Esma J. Doğramacı et al assessed the impact of orthodontic treatment on long-term caries experience and also to analyze the incidence of caries experience in subjects with previous orthodontic treatment. They did not record a significant lower decayed, missing and filled teeth (DMFT) score at age 30 in the previous orthodontically treated participants. No correlation between orthodontic treatment and decayed, missing, or filled teeth or overall DMFT was noted in adjusted models controlling for socio-demographic, dental health behavior and malocclusion status.
This is a retrospective analysis to evaluate with reflectance confocal microscopy (RCM) atypical melanocytic lesions identified in dermoscopy, according to common RCM criteria for the differential diagnosis of BCC and to identify representative RCM parameters for superficial (sBCCs) and nonsuperficial (nsBCCs) BCCs. Results suggest RCM is able to diagnose BCCs mimicking melanoma at dermoscopy.
This is a retrospective study to see the etiology of pleural effusion in our tertiary care center over 1 year period. Tuberculosis is one of the common causes of exudative effusions along with parapneumonic effusions and malignancy. Pleural fluid ADA levels are highly sensitive with good specificity for the diagnosis of etiology of tubercular effusions.
Bellelis P. et al evaluated cytokines related to the natural killer and T-regulatory cells in endometriotic lesions, peritoneal fluid (PF) and the peripheral blood (PB) of patients with deep infiltrative endometriosis. Outcomes suggest that deep endometriosis is a disease out of control. This disease was noted to have progressive and invasive nature, as demonstrated by the disorganized secretion of cytokine regulation and inflammation, which seem to be among the factors responsible for the maintenance of the disease.
Williams DM, et al. performed two-sample Mendelian randomization analyses to investigate if Alzheimer disease (AD) risk would be lower in individuals with lifelong, genetically predicted increases in concentrations of 4 circulating antioxidants that are modifiable by diet. No reduction in AD risk was suggested in relation to higher exposure to ascorbate, β-carotene, retinol, or urate. There was little evidence to imply that pleiotropy had biased results.
Pierre Chauvelot et al retrospectively studied 67 consecutive patients to assess the value of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) and the predictive factors diagnose sarcoidosis among uveitis cases with normal thoracic tomography. They recorded 28.4%of cases with mediastinal hypermetabolic foci on their 18F-FDG PET/CT consistent with sarcoidosis. A relation of older age at diagnosis and the presence of synechiae with an abnormal 18F-FDG PET/CT, with a trend for an elevated ACE, was noticed.
Hesham ElSharkawy et al analyzed 74 generalized chronic periodontitis gCP cases to evaluate the impact of melatonin supplementation with a 2month regimen of 10 mg oral melatonin capsule once daily before bedtime in insomniac people with generalized chronic periodontitis gCP after scaling and root planing SRP They noted a significantly higher clinical attachment levelCAL gain and pocket depth reduction