Aarhus University Hospital is conducting an Observational study in about 625 participants in order to use HR-pQCT techniques to look at the damage and disease activity progression in the hand and wrist joints of patients with rheumatoid arthritis. The study duration involves a one year follow-up with scans of metacarpophalangeal joint and wrist.
The XEN1101 Phase 2 clinical trial is a randomized, double-blind, placebo-controlled study that will evaluate the clinical efficacy, safety, and tolerability of increasing doses of XEN1101 administered as adjunctive treatment in adult patients diagnosed with focal epilepsy.
Advanced Pediatric Emergency Medicine Assembly is scheduled to be conducted between March 19-21, 2019 in Disneyland, Anaheim, CA. This assembly focuses on Pediatric emergency education through specialists for pediatric emergency physicians to health care providers.
The aim of this study is to develop new tools using magnetic resonance imaging (MRI) that will improve the brachytherapy procedure and treatment for participants with gynecologic cancer. This research study is designed to develop new technology using MR imaging to improve the brachytherapy procedure for participants with gynecologic cancer. The brachytherapy procedure will take place in an MRI procedure room within the Advanced Multimodality Image-Guided Operating (AMIGO) suite at Brigham and Women's Hospital. The purpose of the study will be to evaluate whether the use of an MR-tracking device will improve the placement of the brachytherapy catheters. This information will also be used to develop new software for real-time brachytherapy planning by our physics team. The investigators believe that the development of an MR-tracking device will allow them to better place the brachytherapy catheters for radiation treatment and ultimately improve outcomes for patients, including better local tumor control and a lower risk of side effects. The investigators will also evaluate new MRI protocols to better define the tumor at the time of brachytherapy. Brachytherapy treatment planning and delivery will follow the standard of care.
The administration of convalescent plasma is often used for treatment of emerging infectious diseases. This natural history protocol will collect plasma from subjects that were vaccinated to or recovered from an emerging infectious disease of interest, in a manner that the plasma can be given to other subjects as a therapeutic. Any administration of plasma to subjects will be under a separate protocol.
National Institute of Mental Health is conducting an Observational study in about 250 participants with developmental delays or intellectual disabilities in adults between 12 and 21 years of age. They aim to develop a suicide risk screening tool for young adults.
Tasly Pharmaceuticals is conducting a Interventional in 765 participants to screen eligible stable angina patients by exercise tolerance test, the patients eligible for the study will receive one of the three double-blind treatments: high dose T89, low dose T89 or placebo, in a 1:1:1 ratio.
Uppsala University is conducting an Observational Study in 30 participants to determine how biology of pancreatic neuroendocrine tumors change over time. The researchers will assess it through patient symptoms, biochemistry and Scans.
Novartis Pharmaceuticals is conducting a Non-Randomized Interventional Trial in about 61 participants in order to assess the Safety and Efficacy of Everolimus in Adult Patients With Progressive pNET in China. Patients will be administered 10 mg orally each day with appropriate knowledge of study treatment for self-administration at home.
National Institute of Mental Health is conducting an Observational Study in about 250 participants 12 and 21 years of age who have a history of developmental delays or intellectual disabilities in order to create a suicide screening tool. They aim to modify the Risk of Suicide Questionnaire and to detect suicide risk in pediatric clients.