Research Desk

Oct 19, 2019

The purpose of this interventional, phase II study is to evaluate Inhaled RVT-1601 (formerly, PA101B), a new inhalation formulation of cromolyn sodium delivered via the eFlow® Closed System (CS) nebulizer, for the treatment of persistent cough in patients with idiopathic pulmonary fibrosis (IPF).

 

Oct 18, 2019

The purpose of this observational study is to develop a registry to collect long-term data on patients with pediatric cutaneous mastocytosis and develop better knowledge of the timing, symptoms, resolution or progression of the disease, and predictive markers of its severity.

Oct 18, 2019

The purpose of this investigation is to determine the safety and preliminary efficacy of implanting a cochlear implant (CI) in the profoundly deaf ear of an adult with one normal hearing (NH) ear (termed "single-sided deaf" person, or SSD). The potential subjects will have been deafened post-lingually, thus, at one point the now deafened ear did conduct sound from the periphery. The MED-EL Maestro CI system will be implanted in ten (10) SSD patients. The long-term goal of this research program is to determine whether the CI, in combination with the NH ear, may provide improved localization ability and better speech understanding in noise, relative to performance before cochlear implantation.

Oct 18, 2019

The ATR(ataxia-telangiectasia and Rad3 related protein) inhibitor BAY1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas. The purpose of the proposed trial is to evaluate the safety and tolerability of BAY1895344, and to identify the maximum tolerated a dose of BAY1895344 that could be safely given to cancer patients. Further, the response of cancer to the treatment will be determined.

Oct 18, 2019

This pilot study is designed to determine if the rehabilitative benefits of continuous passive motion (CPM) will help preserve/restore the joint function and significantly improve the rate of recovery of patients after the surgical release of elbow contractures better than standard physiotherapy and static splinting.

Oct 16, 2019

A clinical trial to assess the efficacy, safety, and tolerability of mirabegron versus placebo in men with overactive bladder (OAB) symptoms while taking tamsulosin hydrochloride for lower urinary tract symptoms (LUTS) due to Benign Prostatic Hyperplasia (BPH).

Oct 16, 2019

Researchers at the University of Kentucky are conducting a study to learn how two different medications that are used to treat opioid use disorder affect the health of patients who are HIV-positive.

Oct 16, 2019

This phase 3 registrational trial is intended to confirm the safety and efficacy of eculizumab in the treatment of relapsing Neuromyelitis Optica (NMO).

Oct 16, 2019

Researchers will prospectively compare the mean Numerical Rating Scale (NRS) pain score reduction amongst three recommended dosing strategies of intravenous ketamine (0.1 mg/kg, 0.2 mg/kg, and 0.3mg/kg) for acute pain in the emergency department (ED).This study will also examine the frequency of adverse events secondary to ketamine including fatigue, dizziness, nausea, headache, feeling of unreality, changes in hearing or vision, mood changes, generalized discomfort, and hallucinations, changes in vital signs. 

Oct 15, 2019

The purpose of the current study is to confirm safety/tolerability and key pharmacodynamic (PD) effects that are considered to drive clinical benefit in GO patients.