Institut Jerome Lejeune is conducting a study in 47 participants in order to assess the hypothesis that alveolar hypoventilation may be due to ventilatory control disorders caused by dysautonomia, but also to a decrease in the strength of the respiratory muscles within the framework of the global muscular hypotonia described in children with Down syndrome. Patients between ages 4-16 will be included.
Assistance Publique Hopitaux De Marseille is conducting a study in 316 participants to investigate the hypotheseis that extracellular volume fraction measurement could be used as an early predictor of LV dysfunction in the left-sided valve regurgitations.
Institut Paoli-Calmettes is conducting an Observational study in 3000 participants in order to built a database of Institut Paoli-Calmettes patients diagnosed with thyroid cancer. These patient characteristics will be collected in order to set up prospective and retrospective studies. All the patients who come to the centre over a time frame of 10 years will be considered.
Henan Cancer Hospital is conducting a study in 100 participants in order to evaluate the safety and efficacy of domestic injection paclitaxel (albumin binding type) in patients with advanced digestive tract tumors,and to further explore the possible predictors of efficacy.In order to provide more effective chemotherapeutic drugs, prolong survival time and improve quality of life for patients with advanced digestive tract tumors.
Sahlgrenska University Hospital, Sweden is conducting an observational study in 300 participants in order to examine the possible differences in percentage of patients requiring further radiology examinations after basic set-up comparing the routine of initial MRI of abdomen (and pelvic organs) with the routine of initial CT of the abdomen (and MRI of the pelvic organs).
Researchers at the Rockefeller University Hospital are attempting to study the behavioral and neuroendocrine effects of a selective Kappa opioid receptor antagonist.
Mayo Clinic researchers are aiming to determine the safety of using an autologous mesenchymal stromal cell (MSC) coated fistula plug in people with rectovaginal fistulizing Crohn's disease.
Investigators are trying to compare standard of care lung protective ventilation settings with an automated ventilator setting, called Adaptive Support Ventilation (ASV), in patients with acute respiratory distress syndrome (ARDS). This study will compare measurements (i.e. tidal volumes, driving pressure, respiratory rate (RR), compliance, peak airway pressures, plateau pressures, PEEP) with each ventilator technique, and will measure esophageal pressures to compare transpulmonary and respiratory system mechanics.
This is a study to investigate the potential clinical benefit of trilaciclib (G1T28) in preserving the bone marrow and the immune system, and enhancing chemotherapy antitumor efficacy when administered prior to topotecan in patients previously treated for extensive-stage SCLC. The study consists of 2 parts: a limited open-label, dose-finding portion (Part 1), and a randomized double-blind portion (Part 2). Both parts include 3 study phases: Screening Phase, Treatment Phase, and Survival Follow-up Phase. The Treatment Phase begins on the day of the first dose with study treatment and completes at the Post-Treatment Visit. The open-label portion enrolled 32 patients and the randomized portion will enroll approximately 90 patients.
This study examines the aphasia treatment response among Veterans and non-Veterans living with aphasia. It seeks to identify cognitive and neural factors which are predictive of positive response to treatment targeting naming impairments in aphasia. It also examines the dose-response relationship for naming treatment. More broadly, it seeks to determine who aphasia therapy works best for, and how much aphasia therapy is sufficient to achieve a positive treatment response.