This study aims to test the feasibility of rapid acquisition of point of care 3D ultrasound in obtaining abdominal and/or pelvic images. The study will use a newly developed acquisition method and post-processing technique to create three dimensional image models of the abdomen and/or pelvis.
Massachusetts General Hospital Pediatric Epilepsy Brain Imaging Research Study is recruiting children with benign childhood epilepsy (benign rolandic epilepsy, benign epilepsy with centrotemporal spikes) and healthy children without epilepsy, aged 6 years old and above, for a non-invasive brain imaging study to identify markers to predict ongoing seizure risk or cognitive effects in childhood epilepsy using Magnetic Resonance Imaging (MRI), Magnetoencephalography (MEG), electroencephalography (EEG), and neuropsychological testing
Treatment with ACTHAR Gel will result in a reduction of ocular inflammation in patients with active ocular sarcoidosis that requires systemic immunosuppressant therapy (hypothesis)
The aims of this study are: 1) to identify genes that play a role in human pubertal development and reproduction, 2) to characterize the phenotypic spectrum of patients with these gene defects, and 3) to discern the mode of inheritance for disorders caused by these gene defects. We are specifically interested in genes that cause Kallmann syndrome, idiopathic hypogonadotropic hypogonadism (IHH), precocious (early) puberty, and delayed puberty. Individuals do not have to travel to Boston to participate in this study.
This study is testing a medication, called hydroxychloroquine (HCQ) to assess safety and effectiveness to prevent individuals at risk of type 1 diabetes (T1D) from progressing to type 1 diabetes. HCQ is approved by the U.S. Food and Drug Administration as a treatment for malaria, lupus, and rheumatoid arthritis. HCQ has been used extensively for treatment of autoimmune disease in adults, children, and during pregnancy. This medication has not previously been studied as a treatment to prevent T1D. The goal of this study is to learn if HCQ can help prevent or delay progression from normal glucose tolerance (Stage 1) to abnormal glucose tolerance (Stage 2) or type 1 diabetes (Stage 3). The study involves 5 visits in the first 6 months, then 1 visit every 6 months for the remainder of the study.
A multicentre two-group parallel single-blind (outcome assessor) randomized controlled trial (RCT). A cost-effectiveness study alongside a clinical trial using a payer and societal perspective to study the cost-effectiveness of geriatric assessment and management compared to usual care will be conducted. Participants allocated to the control group will receive usual oncology care. Participants allocated to the intervention group will receive a comprehensive geriatric assessment and management in addition to their usual oncology care. The intervention will take 6 months to be completed. Total study follow-up will be 12 months for each participant.
A Randomised Clinical Trial is being conducted by University of Monastir in 400 patients. The authors aim to compare two treatment strategies i.e. standard and intensive treatment protocol with respect to their safety and efficacy in the treatment of Acute Coronary Syndrome. They are studying Intensive Pressure Control as it can highly improve both short term and long term prognosis of such cases.
This phase II trial studies how well olaparib works in treating patients with urothelial cancer with DNA-repair defects that has spread to other places in the body and usually cannot be cured or controlled with treatment. Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
A multiple single-case experimental design Clinical Trial conducted by Hôpital le Vinatier in about 10 participants aims to evaluate the effect of Social Cognition and Cognitive Remediation in order to adjust children's daily life with cognitive deficits in 22q11.2 deletion.
A Washington University sleep research study seeks adults, 65 years or older, to identify sleep and brain wave markers of Alzheimer’s disease before any memory problems occur.