Infectious disease leads to deaths that accounted for more than 25% of all causes of human mortality. But the traditional microbiological diagnostic methods such as specimen culture are sometimes time-consuming and have limited sensitivity. And some bacteria, anaerobes, and viruses may be difficult to cultivate and isolation. Therefore, the accurate identification and rapid classification of pathogenic microorganisms is very important for the patient's precise diagnosis and timely treatment. Small-scale studies on the diagnostic efficacy and prognosis of infection in the next generation have been shown to provide early diagnosis and targeted medication guidance for bloodstream infections and respiratory infections, but the larger-scale validation of next-generation sequencing Technology in the diagnosis and treatment of infectious diseases in the human body is relatively rare. The purpose of this study is to provide a rapid etiological diagnosis of patients by means of next-generation sequencing, to change the way of treatment of patients under the existing traditional pathogen detection by means of accurate description of pathogens and monitoring their dynamic changes, and to provide patients with more accurate treatment.
The larynx and vocal folds undergo many age-related changes in their physiology and structure that can lead to undesirable effects on the voice, with changes in the respiratory system compounding these deficits. These changes, also called presbyphonia, can have serious detrimental effects on the lives of elderly individuals. There are few studies that have evaluated the use of voice therapy treatment options for these patients. The primary aim of this study is to test whether the addition of expiratory muscle strength training (EMST) to a current, validated voice therapy protocol aimed at treating presbyphonia, (phonation resistance training, PhoRTE) can improve outcomes of therapy.
This is a Prospective, Observational, US-based Study Assessing Outcomes, Adverse Events, Treatment Patterns, and Quality of Life in Patients Diagnosed With Mycosis Fungoides Cutaneous T-cell Lymphoma and Treated With Valchlor®. The Valchlor PROVe study is a multi-center, prospective, observational, US-based drug study that longitudinally follows patients with MF-CTCL who are receiving therapy with Valchlor.
This is a double-blind, placebo-controlled study with 50 healthy subjects randomized to intake 300 mg Ovoderm® or a placebo treatment during 60 days was performed. Skin elasticity, transepidermal water loss, skin firmness, and skin fatigue were measured before and after the treatment. At the end of the study, the group intaking Ovoderm® improved the skins barrier function, showed by the tendency of transepidermal water loss to decline.
The study will enable the clinical applicability of the multiple-spectral-sonography for detection of severe brain injury in ICU patients. For this, the ACG diagnostic system (Sonovum AG, Leipzig, Germany) should be used as an additional diagnostic tool in a prospective single-center study.
Researchers in Spain have developed a 3D bioprinter that produces skin suitable for transplanting into patients It is currently undergoing European approval The challenges of making human body parts with 3D printing is not only replicating the complexity of the structures but also ensuring that they survive transplantation in a living body
Researchers found that plastic surgeons correctly identified the diagnosis of body dysmorphic disorder BDD in less than 5 percent of patients who screened positive for this disorder Nearly one in 10 patients seeking facial plastic surgery suffers from a mental illness that distorts their perception of physical defects but doctors often dont spot the problem
For men with bladder cancer androgen suppression therapy may be prophylactic for intravesical recurrence according to a study published in the February issue of The Journal of Urology The researchers found that intravesical recurrence developed in 125 and 301 of men with and without androgen suppression therapy during a median followup of 36 and 30 years respectively
A new study published sheds new light on the relationship between the diabetes drug metformin and the biology of cancer cells This study demonstrates that metformin has effects on head and neck cancers at safe doses that are at or lower dose and that it changes headandneck tumor biology in a way that likely makes the cancer easier to kill
Cesarean delivery rates have increased during the last few decades and it has become the most common surgery during a womans reproductive years There is currently no definite evidence regarding the best method for skin closure after a cesarean surgery Safety of the operation healing and cosmetic outcomes are important and should influence the physicians choice of skin closure methodology