The FDA approved trastuzumab-dttb (Ontruzant, Samsung Bioepis) for all eligible indications of the reference product, Herceptin (Genentech). For treatment with this patients should be selected for treatment based on an FDA-approved companion diagnostic test. Trastuzumab-dttb is indicated for adjuvant treatment of HER2-overexpressing node-positive or node-negative breast cancer.
The Investigators will approach a broad range of people over the age of 50 who have previously taken part in various research studies and consented to be recontacted for further research. Participants will be asked questions to assess their memory and other cognitive function. The participants will also undertake a brain scan, provide a sample of spinal fluid, blood, urine, and saliva to look at markers in these bodily fluids that may change in Alzheimer's disease. The Investigators will then follow these participants until December 2019 repeating these tests annually. This will be called the EPAD Longitudinal Cohort Study (EPAD LCS). The main reasons for EPAD developing a cohort are to help the Investigators understand more about what happens to people before dementia develops, and to help recruit people more quickly into the EPAD trials of new medications or other interventions expected to prevent dementia.
A Phase 3 Study to Evaluate ADX-102 Ophthalmic Solution in Subjects With Non-infectious Anterior-uveitis.The purpose of this study is to evaluate the efficacy of ADX Ophthalmic Solution on anterior chamber cell count and evaluate the signs and symptoms of ADX-102 Ophthalmic Solution on anterior chamber flare in subjects with non-infectious anterior uveitis.
This phase III trial studies how well carvedilol works in preventing cardiac toxicity in patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. A beta-blocker, such as carvedilol, is used to treat heart failure and high blood pressure, and it may prevent the heart from side effects of chemotherapy.
Diabetes has recently been referred to as "the epidemic of the 21st century". The reason why women with type 1 diabetes have a 2-3 fold greater risk of cardiovascular disease (CVD) compared to men with type 1 diabetes is unknown. The purpose of this study is to investigate whether or not estrogen contributes to vascular dysfunction in premenopausal women with diabetes.
Mayo Clinic is investigating the effectiveness of the combined use of vitamin C, thiamine and corticosteroids versus indistinguishable placebos for patients with sepsis. The objective of this study is to demonstrate the effectiveness of combination therapy using vitamin C, thiamine and corticosteroids in reducing mortality and improving organ function in critically ill patients with sepsis.
A Non-Randomized ongoing Clinical Trial at University of California aims at finding if giving topiramate to neonates born with congenital heart disease before and after surgery, can reduce the amount of brain damage caused by the heart disease as well as the surgery to correct the same.
A randomized controlled, open labeled multicenter, non-inferiority trial being conducted at University Hospital, Basel, Switzerland aims at demonstrating the non-inferiority of treatment with ASA to anti-coagulant treatment with vitamin K antagonists in patients after a cervical artery dissection.
An ongoing Observational study of 132 newborns aged 2 to 5 days, with a gestational age greater than or equal to 30 weeks of amenorrhea, aims to determine if the technique of Liquid Chromatography coupled to tandem Mass Spectrometry allows dosage of adrenal steroids on dried blot spot samples with the same efficiency and sensitivity.