Isabella Aquila et.al. describe a case of Sudden death due to Takayasu’s arteritis and how histopathology came in handy by revealing eosinophilia in the aortic wall, consistent with a vasculitis such as Takayasu’s arteritis as the autopsy only showed sclerosis of the thoracic aorta, abdominal aorta and coronary arteries.
Shuquan Zhao et.al. presented a case of a a 21-year-old woman diagnosed with “acute gastroenteritis” who expired 4 days later. Autopsy findings revealed an inflammatory polypous embolic located at 1.0 cm from the left anterior descending branch. To find the real cause of this embolus, virus detection was performed through RT-PCR, however the findings were negative.
During a craniotomy, hemostatic materials such as oxidized cellulose and cotton pads, commonly used to control bleeding, may cause a granulomatous reaction that may produce space-occupying mass lesions termed textiloma (or gossypiboma). Nicola Montemurro et al presents the case of a 46-year-old female who underwent a right frontotemporal craniotomy and surgical removal of an intraparenchymal cerebral hemorrhage. The patient developed a textiloma during the postoperative period that led to seizures.
Follicular lymphoma is an indolent non-Hodgkin lymphoma that is most prevalent among the elderly population. An 82-year-old female with refractory follicular lymphoma achieved a partial response with idelalisib treatment, Despite experiencing two incidences of the psoriasis-like rash during the treatment the patient was able to restart treatment successfully and maintain a continued partial response.
Despite providing palliation and prophylaxis, whole-brain radiation therapy (WBRT) reduces local recurrence probability and improves overall survival, it is evident that WBRT is linked to neurocognitive deficits due to radiation-induced damage of the hippocampus. Therefore, minimizing the hippocampal dose to the least possible level is of high clinical relevance. Adams Hei Long Yuen et al investigated the potential of a radiation therapy technique with split-arc and reduced field size, namely split-arc partial-field volumetric modulated arc therapy (sapf-VMAT) to spare the hippocampus during WBRT.
F. Coussy et al sought to determine the response to PI3K and MAPK pathway inhibitors in patient-derived xenografts of MBCs with targetable alterations. The treatment of metaplastic breast cancer PDXs by activation of the PI3K-AKT-mTOR and RTK-MAPK pathways at the genomic and protein levels with a combination of PI3K and MEK inhibitors resulted in tumor regression in mutated models and may, therefore, be of interest for therapeutic purposes.
Isaac Biney reported the case of a 65-year-old female with limited SSc complicated by severe PAH and a nonhealing left lower extremity venous ulcer. HBO2T was successfully used as an adjunct in her management resulting in complete resolution of the venous ulcer and improved quality of life without any adverse effects on her pulmonary arterial hypertension.
This is a case of a 77-year-old man, who was admitted because of progressive preauricular swelling. Antibiotic therapy did not show any improvement. FNAC followed by ZN stain tested positive for Tuberculosis. Post which anti-tubercular drugs were initiated.
The patient was suffering from leg tremor on standing for 2 years without any neurological signs. Since her orthostatic tremor with low-frequency discharge was responsive to dopaminergic medication, Fumihito Yoshii speculated that it might be a premotor sign of Parkinson’s disease. Her leg tremor symptoms completely disappeared post administration of levopoda 200 mg and pramipexole 0.75 mg.
A 49-year-old female a known case of Anklyosing Spondylitis was admitted for surgery due to Aortic Insufficiency, histological findings revealed fibrosing endocarditis involving the aortic valve and there was also involvement of the Aortic root. Later on narrowing of the left main coronary artery was also observed.