Research Desk

Apr 19, 2019

This is an open-label, multi-dose, single-arm, multi-center, Phase 1, dose-escalation study to define a maximum tolerated dose and schedule (MTDS), describe preliminarily safety, and to assess PK, immunogenicity, immunomodulatory activity, and potential anti-tumor activity of MGD006 in patients with AML or MDS whose disease is not expected to benefit from cytotoxic chemotherapy. The primary goal of this Phase 1, dose-escalation study, is to determine the maximum tolerated dose level of MGD006 in patients with AML and MDS whose disease is not expected to benefit from cytotoxic chemotherapy.

Apr 19, 2019

This clinical study is researching a new technology to treat a specific type of knee cartilage injuries. The study is comparing their product and technique to a standardized and regularly performed procedure. Patients who qualify for this trial will receive all study related medication and care at no cost to them or their insurance company. The study is covering the entire cost of surgery for patients who qualify.

Apr 19, 2019

This study evaluates the ability of the drug sildenafil to improved exercise capacity, cardiac performance during exercise, and quality of life in patients with moderate to severe CF lung disease. 3/4 of the subjects will receive sildenafil and 1/4 will receive a placebo.

Apr 19, 2019

A 14-year-old adolescent with short stature and delayed puberty, was admitted in a Paediatric Endocrinology outpatient clinic. His familial target height was on percentile 3–10.  After a careful investigation, he was found to have a 45,X/46,X,idic(Y)(p11.32) mosaicism. 

Apr 19, 2019

A 38-year-old with sickle cell disease-associated Pulmonary hypertension and acute chest syndrome was successfully managed with inhaled and oral pulmonary vasodilators in the setting of persistent elevations in pulmonary vascular resistance leading to acute RV failure and cardiogenic shock. 

Apr 19, 2019

A 35-year-old patient was admitted to endocrinology outpatient department with complaint of pain in the neck. Physical examination revealed 2 cm nodule on the thyroid right lobe. Serum thyroid hormone levels were within normal range. Ultrasonography revealed a 23x15 mm hypoechoic nodule with micro calcifications and cystic areas on the right lobe. 

Apr 19, 2019

 A 63-year-old male with severe iron deficiency anemia on biweekly intravenous iron infusions and weekly packed red blood cell transfusions presented with melena over several months. Upper endoscopy demonstrated a clean-based gastric body ulcer and nonbleeding gastric varices. Histology of the gastric ulcer was suggestive of iron-induced gastric mucosal injury.

Apr 19, 2019

 A 51-year-old man came with Rasmussen’s aneurysm that was successfully treated by proximal coil blocking with n-butyl-2-cyanoacrylate (NBCA) injection via the pulmonary artery alone. With proximal coil blocking, a sufficient amount of NBCA could be injected without unintended reflux of the NBCA cast to the proximal pulmonary artery. 

Apr 19, 2019

A new UCLA research suggests that one can save costs for patients and resources of hospitals by eliminating unnecessary procedures before cataract surgery. The researchers added when the doctors did not opt for chest X-rays, electrocardiograms and other preoperative procedures with no significant relation with Cataract surgery- the amount of money saved added up to $67,241 over a period of three years at a medical centre. 

Apr 19, 2019

This multicenter retrospective study is to describe the various presentations and identify predictive factors of death in patients with Calciphylaxis (CPX). Cerium nitrate may lead to vascular decalcification and chelation of reactive oxygen species, and prevent infection. Cerium nitrate-silver sulfadiazine was associated with better outcomes and should be tested in a prospective comparative trial in CPX patients.