Research Desk

Jul 19, 2019

Dr. Kavanagh, Eye Associates of South Texas with offices in Seguin, San Antonio is the first ophthalmologist in South Texas (San Antonio), to implant Dextenza a steroid-releasing device by Ocular Therapeutix to decrease pain and inflammation for 30 days after cataract surgery. Possibly saving the patient having to put in 120 drops for steroid over a month period. The techniques of insertion are discussed, as well as Dr. Kavanagh's preferred technique of placing Dextenza before cataract surgery instead of after.

Jul 19, 2019

According to a new report from the independent national healthcare watchdog organization, majority hospitals do not meet the Leapfrog Group's minimum hospital or surgeon volume standards for safety and they also do not have adequate policies to monitor appropriateness. Out of the eight high risk procedures that were assessed, very few hospitals met the volume standard for patient safety especially in cases of open abdominal aortic aneurysm repair and esophageal resection. 

Jul 19, 2019

The objective of this study was to elucidate the mechanisms of the formation of severe and prolonged pressure ulcers (PUs) under the zinc deficiency condition. They assessed PUs formation after cutaneous ischemia-reperfusion (I/R) injury in mice fed with a zinc-adequate (ZA) or a zinc-deficient (ZD) diet from 2 weeks before I/R injury. Wound size, vascular damage, apoptotic cells, adenosine triphosphate (ATP) amount, and the number of Langerhans cells (LCs) in I/R area were analyzed. Also evaluated the extent of oxidative stress in I/R area in OKD48 mice through bioluminescence detection. Zinc deficiency might increase cutaneous I/R injury-induced vascular damages, oxidative stress, and apoptosis, as well as ATP amount in I/R area due to the loss of LCs.

Jul 19, 2019

In this single armed study with historical control they tested the hypothesis that before salvage surgery administration of immunonutrition would decrease complications in this high risk population of recurrent head and neck squamous cell carcinoma. In patients undergoing salvage surgery for recurrent head and neck squamous cell carcinoma, preoperative immunonutrition exhibited favorable effects on the complication rate and consequently reduced the length of hospital stay.

Jul 19, 2019

This randomized, multicenter controlled study is to compare the survival outcomes of neoadjuvant three-dimensional conformal radiotherapy (RT) followed by hepatectomy with hepatectomy alone in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT). For patients with resectable HCC and PVTT, neoadjuvant RT provided significantly better postoperative survival outcomes than surgery alone. IL-6 may predict response to RT in these patients.

Jul 19, 2019

In this multinational, phase 2, dose-finding study and extension study, they evaluated the safety and side-effect profile of vosoritide in children (5 to 14 years of age) with achondroplasia. A total of 35 children were enrolled in four sequential cohorts to receive vosoritide at a once-daily subcutaneous dose of 2.5 μg per Kg of body weight. In children with achondroplasia, once-daily subcutaneous administration of vosoritide was associated with a side-effect profile that appeared generally mild. Treatment resulted in a sustained increase in the annualized growth velocity for up to 42 months.

Jul 19, 2019

The aim of this study was to determine whether the SeptiFast® (SF) assay is applicable to the culturing of bronchoalveolar lavage (BAL) of children with pulmonary infections and whether the frequency of pathogen detection is enhanced by the use of this multiplex polymerase chain reaction (PCR) method. Compared to conventional culture, the use of the SF assay on the BAL of children with pneumonia increases pathogen detection rates and therefore adds important information to guide anti-infective therapy.

Jul 19, 2019

The IRS issued guidance that makes it easier for patients enrolled in high-deductible health plans to get coverage for medications and drugs to treat chronic illnesses, including asthma, congestive heart failure, and diabetes. The guidance noted that patients with certain chronic conditions face cost barriers that prevent them from seeking necessary care. Failing to address those needs often leads to consequences such as heart attacks and strokes that require even more medical care.

Jul 19, 2019

Researchers at the Rockefeller University Hospital are attempting to study the behavioral and neuroendocrine effects of a selective Kappa opioid receptor antagonist.

Jul 19, 2019

Mayo Clinic researchers are aiming to determine the safety of using an autologous mesenchymal stromal cell (MSC) coated fistula plug in people with rectovaginal fistulizing Crohn's disease.