This is a report of four cases with metastatic esophageal squamous cell carcinoma pretreated with standard chemotherapy who then received salvage-line chemotherapy with oxaliplatin and 5-fluorouracil plus l-leucovorin (FOLFOX). Study findings suggested that modified FOLFOX-6 (mFOLFOX-6) for patients with metastatic ESCC pretreated with standard therapies (including cisplatin) has potential therapeutic activity and acceptable toxicity.
The purpose of this retrospective monocentric study is to determine if sequential interventional therapy can become a mainstay option in providing palliation from fastidious osseous neoplasms in patients with pain refractory to oral analgesia and radiotherapy. This retrospective study shows that sequential intervention with transarterial embolization, cryoablation, and osteoplasty is both safe and efficacious for bone pain refractory to the current standard of care.
According to reports published in the journal Stem Cell Reports, insulin-like growth factor II gene in adult stem cell provides key support for the existence of stem cells in the intestine. The researchers added that these genes show unregulated self-renewal and proliferation which may contribute to colorectal cancers.
The purpose of this study was to elucidate the molecular effect of leg length discrepancy (LLD) on lumbar intervertebral discs (IVD). Study results suggest that LLD is a predisposing factor for molecular IVD alterations, which are detectable even before morphological pathologies could be found.
This is a case of 34-year-old nonsmoker male with a history of left lower lobe lung scar secondary to a pulmonary contusion from a motor vehicle accident in 2012 was admitted with shortness of breath and cough. A computed tomography (CT) angiography of the chest demonstrated bilateral pulmonary emboli, left lower lobe mass, left lung septal thickening, and mediastinal lymphadenopathy. A CT-guided biopsy of the mass was performed, and pathology was consistent with lung adenocarcinoma.
The purpose of this study is to observe the effect of obesity on exercise capacity in unilateral diaphragm paralysis (UDP) patients. All obese and nonobese patients with UDP undergoing cardiopulmonary exercise testing (CPET) during a 32-month period in the exercise laboratory of an academic hospital were compared to a retrospectively identified cohort of obese and nonobese controls without UDP, matched for key features. Study results suggest neither UDP nor obesity alone significantly reduced exercise capacity. Superimposed UDP and obesity interact to create a ventilatory limitation to exercise, with reduced peak-VO2, exercise time, and work rate.
According to research published in Radiology, a “research roadmap" has been developed on helping researchers use artificial intelligence (AI) algorithms. The researchers added that the blueprint will provide for professional societies, funding agencies, research labs, and everyone else working in the field.
The U.S. Supreme Court cast aside pharmaceutical company Allergan Plc’s unorthodox bid to shield patents from a federal administrative court’s review by transferring them to a Native American tribe. The justices left in place a lower court ruling upholding the authority of a U.S. Patent and Trademark Office tribunal to decide the validity of patents covering Allergan’s dry eye drug Restasis, refusing to hear the company’s appeal.
Pediatric Diabetes is the leading vehicle for international dissemination of research and practice relating to diabetes in youth. It publishes articles on epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes in childhood and adolescence. The current issue consists of articles on Children with Type-1 Diabetes, glucose monitoring methods of continuous glucose monitoring etc.
The U.S. Department of Health and Human Services (HHS) recently proposed two new rules designed to increase patient and provider access to health records. The proposed rules will support seamless and secure access, exchange, and use of electronic health information. CMS and ONC proposed complementary rules facilitating patient access to and the flow of health information.