Vedolizumab Seems Safe during Pregnancy

11 Apr, 2019 ,

Pregnant women with inflammatory bowel disease (IBD) who take vedolizumab (VDZ) seem to be at low risk for adverse events, but a higher rate of spontaneous abortions in those taking the drug argue for a larger study with longer follow-up, researchers say.

"Management of IBD during pregnancy is challenging, as it strongly influences the course of pregnancy," Dr. Ariella Bar-Gil Shitrit of the Shaare Zedek Medical Center, in Jerusalem, told Reuters Health by email. "We present novel and promising results" regarding VDZ's safety.

Dr. Shitrit and colleagues analyzed data from 390 women with IBD (mean age, 30), including 24 treated with VDZ (mean years of disease, 9.1), 82 treated with anti-tumor necrosis factors (mean years of disease, 8.3) and 284 who received conventional therapy with 5-aminosalicylic acid agents and thiopurines (mean years of disease, 7.7).