An Immune Gene Expression Signature Distinguishes Central Nervous System Metastases from Primary Tumours in Non–Small-Cell Lung Cancer

European Journal of Cancer
04 Jun, 2020 ,

Georgios Tsakonas conducted a study to understand the alterations in gene expression in brain metastasis versus primary tumour as it may increase aggressiveness and impair therapeutic efforts. The researchers concluded  identified a unique gene downregulation pattern in brain metastases compared with primary tumours. This finding may explain the lower intracranial efficacy of systemic therapy, especially immunotherapy, in brain metastasis of patients with non–small-cell lung cancer.